Online Ahead of Print
Transplanting fecal bacteria from healthy donors might prove to be effective in resolving cancer immunotherapy-triggered colitis, a pair of case reports has suggested.
Younger age at diagnosis and delayed childbearing are reprioritizing fertility-preserving treatment options.
Use of a computerized brain exercise program designed to help people sharpen their cognitive function was found to be effective against chemobrain in breast cancer survivors.
A reflection on how clinicians' own illness humanizes them as healers.
A review of the cultural and religious beliefs of Ashkenazi Jewish women that may challenge adherence to breast cancer screening and genetic testing recommendations.
The ASCO 2018 Cancer Opinions Survey revealed an almost unbelievable fact about Americans' beliefs regarding cancer care. This report examines the lengths some people with cancer will go to in pursuing a "cure" for their disease.
What are some good Internet resources for patient information about cancer treatment regimens?
In a 2-pronged study, researchers determined that antiperspirant/deodorant use is a significant part of quality of life for patients with breast cancer, and the practice does not increase risk of skin reactions in the axilla.
[OncoTargets and Therapy] This meta-analysis evaluates prognostic factors of OS and RFS in patients treated with radiofrequency ablation.
Mean changes in hematologic indices found similar regardless of same-day or prior administration of B12 supplementation in patients receiving pemetrexed for NSCLC or pleural mesothelioma.
A social worker reviews the challenges patients and their families will face dealing with anticipatory grief and bereavement during festive holiday activities.
[Cancer Management and Research] Researchers sought to determine the effect of intravenous hydration on plasma methotrexate clearance on pediatric oncology patients receiving HD-MTX for ALL, NHL, or osteosarcoma.
A review of studies investigating the safety and efficacy of integrative and complementary medicine practices sought to determine their effects on children with cancer.
What are some tips for speaking to patients about adherence to oral cancer medications?
[OncoTargets and Therapy] A meta-analysis sought to support the efficacy and safety of apatinib in the treatment of solid tumors that was previously reported in previous studies.
How much of what's online is off limits? A review of ethics, principles, and guidelines for nurse and social worker behaviors regarding online searches.
A retrospective study sought to determine the effectiveness of surgical intervention for elderly female nursing home residents with breast cancer.
This fact sheet explores the technology of cell phones, radiofrequency energy and how it may affect the body, and the findings of research studies about cell phone exposure and cancer risk.
[OncoTargets and Therapy] In this systematic review and meta-analysis, researchers sought to determine the predictive value of skin rash in patients with advanced pancreatic cancer treated with gemcitabine plus erlotinib.
In this retrospective study, researchers sought to determine the efficacy of nedaplatin vs cisplatin for the treatment of malignancy-induced malignant pleural effusion.
Lee Hillstrom shares his cancer experience and highlights the critical support he received from a nurse navigator and cancer counselor.
How do you answer when the patient or family asks, "What is next?" More importantly, though, you need to recognize if they are asking that question, or is there something else they are really asking.
A review of the most feared effects of breast cancer treatment and resources to recommend to patients coping with these effects.
[Breast Cancer: Targets and Therapy] Researchers sought to determine the incidence of subcutaneous side effects in patients with early-stage breast cancer treated with AHF-RT vs standard fractionated RT after breast conserving surgery.
This in-depth review examines the inherent challenges of providing cancer care for incarcerated patients.
In this Case Study, Ms Lyle discusses diagnosis and early management of myelofibrosis in a 72-year-old male patient.
[Cancer Management and Research] Data from a total of 16,998 patients with breast cancer included in the SEER database were evaluated to determine the prognosis of various treatment options for elderly patients.
Researchers are seeking genetic biomarkers that can predict which patients are most likely to suffer radiotoxicities and which can safely undergo intensified radiation treatment regimens.
An international team reviews osimertinib-associated dermatologic adverse events in patients treated with the third-generation EGFR-TKI.
A nurse-led study explored the significance of nurse navigators for patients with lymphoma approaching their transition from acute care to survivorship care.
[Breast Cancer: Targets and Therapy] This research examines the mechanism of action of L-DOX and its most common side effects and highlight results of its use in clinical trials for the treatment of BC as single agent and in combination with other commonly used chemotherapeutics.
A review of how emotions, social perceptions, and physical effects influence coping skills for men with prostate cancer.
Researchers at St Jude Children's Research Hospital sought to determine what indicators in survivors of CNS tumors can predict the survivor's ability to live independently as an adult.
[Lung Cancer: Targets and Therapy] This review presents a summary and update of the latest evidence for patient selection, efficacy and outcome of primary treatment, prophylactic cranial irradiation (PCI) in the treatment of patients with SCLC.
Skin cancer screening programs have led to diagnoses of melanoma that would have otherwise been missed, but the overall public health benefit of such programs remains unclear.
What information is there about using the newer high-dose flu vaccine in patients with cancer?
This fact sheet explores the possible cancer risks caused by the chemical acrylamide in foodstuffs and consumer goods.
[OncoTargets and Therapy] Although first-line therapy is effective, relapse is common; but many patients are good candidates for second-line therapy. This report reviews current published data on second-line therapies for advanced pancreatic cancer.
Oral care by a dentist was found to reduce pathogenic bacterial plaque thereby decreasing the risk of postoperative pneumonia, a potentially fatal adverse effect, in patients undergoing surgical procedures for cancer.
In a recent report, researchers evaluate the efficacy of newer 5HT3-RAs for the prevention of CINV in patients with cancer receiving moderately or highly emetogenic chemotherapy.
[OncoTargets and Therapy] The challenges of reversible posterior leukoencephalopathy syndrome (RPLS), a rare clinical-radiologic syndrome, are presented in a case study and review of the literature on RPLS.
In a review of data from more than 20,000 veterans, researchers determined the effects of palliative care on suicide rates among veterans with advanced lung cancer.
[Cancer Management and Research] Retrospective study investigates the effect of radiotherapy on long-term survival in patients who underwent mastectomy for breast cancer at various time intervals.
This simple framework for communicating can be adapted to fit each situation, regardless of it being a nurse-to-patient or a nurse-to-nurse setting.
Wearable activity monitors offer oncology care teams an unbiased glimpse into patients' health behaviors and improved reports on performance status.
In a randomization of women with early-stage breast cancer, researchers explored the potential benefits of chemotherapy for women whose Oncotype DX RS was midrange.
What is the concern with antioxidants and chemotherapy or radiation?
The Efficacy of High Pressure Oxygen Combined With Chemotherapy in Postoperative Patients With Advanced Gastric Cancer
[Translational Cancer Research] In this research, a combination of gastric cancer postoperative with hyperbaric oxygen therapy to explore the clinical application in postoperative chemotherapy for advanced gastric cancer.
[Journal of Hepatocellular Carcinoma] A review of the manifestations, treatments, and challenges associated with hepatocellular cancer pain.
A reflection on how these elements affect patients at the time of diagnosis, during their cancer journey, and how it can change their life in survivorship.
[OncoTargets and Therapy] Evidence increasingly suggests that pembrolizumab has a significant role in first- and second-line therapy for NSCLC. This review presents the results of previous and ongoing studies and discusses biomarkers that can potentially identify eligible candidates for treatment with the PD-L1 inhibitor.
Recent research implicates patients' immune cells appear to stimulate radiation abscopal effects, raising the possibility that combining radiotherapy and immunotherapy could yield previously-untapped treatment synergies to improve tumor control.
Are there resources that outline if chemo premeds must be mixed in the laminar air flow hood?
[OncoTargets and Therapy] Disease specifics, demographics, clinical presentation, and pathology, plus diagnosis and management of ocular SC are highlighted and discussed, including recent advances in management of this aggressive malignancy.
This fact sheet reviews Paget disease of the breast symptoms, diagnosis, and treatments.
Information patients find online can be a great concern for oncology nurses, especially when a diagnosis has an uncertain prognosis. In this follow-up study, researchers in Boston sought to determine the quality of the online resources patients with cancer, particularly pancreas, are finding.
Researchers sought to determine if men with prostate cancer would derive the same benefits from hypnosis as women with breast cancer. Their results highlight significant differences in what is helpful for men vs women.
This case follows a 35-year-old man with polycythemia vera from presentation in the ED through initiating and modifying treatment with phlebotomy and hydroxyurea, and eventually achieving optimal management of symptoms and CBC with ruxolitinib.
[Cancer Management and Research] A review of the background and current challenges in 4 key areas of radiotherapy are presented, plus potential future options for creating safe and effective strategies in radiotherapy.
What are some helpful Internet resources for reliable information about herbal products?
Four of 9 lung cancer screening models were shown to effectively select the most appropriate candidates for low-dose CT lung cancer screening among US ever-smokers.
[Cancer Management and Research] A review of fertility complications induced by chemotherapy and radiotherapy, as well as possible treatment options for HL patients with fertility problems.
A prospective trial with more than 2000 women who underwent mastectomy with immediate breast reconstruction sought to determine patient satisfaction with their breasts and quality of life annually over 4 years after their procedure.
This installment demonstrates how the caregiver's cancer journey often parallels that of the patient with cancer, highlighting their need for evolving support through survivorship.
[OncoTargets and Therapy] Researchers investigated the anticancer effects of a novel sulfonamide derivative in the treatment of colorectal cancer.
Educational intervention for oncology clinicians at a rural Michigan oncology clinic does not demonstrate a statistically significant increase in referrals to rehabilitation; however, results show a clinically significant improvement in identification of need, communication among staff, and potential for greater referrals.
What should be explained to patients regarding placebo use in controlled trials?
[Journal of Hepatocellular Carcinoma] In this case series, the authors present procedure and treatment specifics for 2 patients with HCV who developed HCC, and discuss the potential role of DAA therapy and immunosurveillance.
Have you ever thought about what is meant — or understood — when you say to a patient "It's going to be okay"? Hearing an exchange between her grandson and a pediatric nurse prompted Ann Brady to reflect on abbreviated communications.
Patient advocacy can lead nurses to take on great challenges in the course of caring for their patients or to brave the elements to retrieve replacements for a patient's missing clothes.
This fact sheet examines the possible cancer risks and also possible protective benefits associated with the use of oral contraceptives.
[Cancer Management and Research] An investigation into the efficacy of microwave ablation and minimally invasive open decompression treatment for breast cancer with thoracic metastases.
This overview provides a snapshot of the shift in cancer care costs and age of patients, reviewing the 4 most commonly diagnosed cancers.
In updating its 2012 recommendations, the US Preventive Services Task Force changes its stance on PSA-based screening for prostate cancer in men older than 50. The new guidelines advocate for a patient-physician discussion of the benefits of testing vs the potential harms.
[Cancer Management and Research] The prognostic values of overall survival and cancer-specific survival for bone sarcomas of the hands or feet were assessed using Cox proportional hazards regression model with univariate and multivariate analyses.
A multinational retrospective study investigated the long term effects of exercise intensity and frequency on all-cause and cause-specific mortality among adult survivors of childhood cancers.
Is trastuzumab classified as an immunotherapy? If so, how does it work?
[Cancer Management and Research] In this study, researchers explored the potential of andrographolide and topotecan, separately and together, in the in vitro treatment of the U937 acute myeloid leukemic cell line.
Marissa Fors, director of CancerCare's Susan G. Komen® Breast Care Helpline, talked with Dr Penelope Damaskos, of Memorial Sloan Kettering Cancer Center, about breast cancer risk and related challenges for women who identify as lesbian and their healthcare providers.
[OncoTargets and Therapy] In a review of cancer stem cells (CSCs)/ovarian cancer stem cells (OCSCs), researchers discuss the implications of immunotherapy development based on studying cancer evolution by CSCs, and targeting OCSC surface markers to develop CAR-T immunotherapy.
Why are European patients better able to tolerate high doses of capecitabine than US patients?
A review of current options and ongoing trials for managing ARIE, a common esophageal adverse effect caused by radiotherapy to the thoracic region for lung, breast, or head and neck cancers, or lymphoma.
This fact sheet reviews cancer in adolescents and children, including possible causes, treatment, and the general outlook for childhood cancers.
Results from a study on an innovative program from the Mayo Clinic in Rochester, Minnesota, demonstrates the potential positive effects of providing hospitalized patients with brief one-on-one art lessons.
[Lung Cancer: Targets and Therapy] This case study demonstrates that genomic profiling may still benefit patients who fail checkpoint inhibitor therapy despite having high tumor mutational burden and PD-L1 positivity.
How long after receiving chemotherapy should patients wait to have unprotected sex?
[OncoTargets and Therapy] Management of brain metastases in patients with EGFR-mutant NSCLC is controversial. In this study, researchers find combination and sequential treatment with EGFR-TKIs, chemotherapy, and radiotherapy is beneficial.
Results of a literature review highlighted 5 strategies for improving the management of urgent care situations in patients with cancer.
A new US Preventive Services Task Force Evidence Report is suggesting that greater efforts are needed to educate children and young adults with fair skin about risks of sun exposure. Although the Task Force recommendations are directed at primary care, its members are encouraging oncology nurses to take note of these new findings.
Please clarify the role and responsibilities of oncology nurse navigators (ONNs) vs those of the oncology social workers (OSWs).
[Lung Cancer: Targets and Therapy] Italian researchers report on the role of GLI1 in the development of lung cancer, and review its potential as an effective therapy for lung cancer.
What impact do the new pharmacy regulations (USP) have on nursing staff?
A review of HER2-positive breast cancer, including etiology, diagnosis, and treatments.
[Cancer Management and Research] A review of marginal zone lymphomas, a common and varied group of hematologic malignancies, and their treatment, with a focus on the Bruton's tyrosine kinase ibrutinib.
What is the protocol for extravasation of Mitomycin C?
The use of a contractor to make home repairs offers an interesting analogy to the shared decision-making experience.
A review of shared decision making with men about undergoing PSA testing revealed that although full SDM discussions are increasing, variations in whether these discussions occur and how much information is shared still exist.
[Gastrointestinal Cancer: Targets and Therapy] This review presents the most up-to-date molecular, clinical, and therapeutic data, including an overview of a current phase 3 study assessing the efficacy of simultaneous BRAF, EGFR, and MEK inhibition among patients with BRAFV600E-mutant CRC.
A group of Australian researchers report study findings that demonstrate a significant improvement in PFS in patients with relapsed/refractory CLL treated with venetoclax plus rituximab compared with the standard care.
Faced with an increasing CLABSI rate on their oncology unit, nurse leaders at this rural Northwest hospital surveyed their staff to identify the changes they needed to make. Implementing those changes resulted in a dramatic improvement in patient care outcomes.
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- Hormone Therapy for Breast Cancer (Fact Sheet)
- Cancer Treatment and Research: What Lies Ahead in 2019
- 9-Week Trastuzumab Course Not Noninferior to Standard Course for HER2+ Breast Cancer, But Does Offer a Benefit
- Toxicity Similar, But Overall Survival Poor in Cetuximab vs Cisplatin for HPV-Positive Oropharyngeal Cancer
- Mindfulness-based Stress Reduction in Patients With Differentiated Thyroid Cancer Receiving Radioactive Iodine Therapy: A Randomized Controlled Trial
- Brain Exercise Program Eases Chemobrain in Breast Cancer Survivors
- Hormone Therapy for Breast Cancer (Fact Sheet)
- Counseling on the Dangers of Vaping
- Radical Prostatectomy vs Active Surveillance: Results of Nearly 3 Decades of Follow-up
- Potential of Fecal Microbiota Transplantation in Managing Immunotherapy-Associated Colitis
- Gastrointestinal Perforation Complicates Management of Mantle Cell Lymphoma
- Modernizing Eligibility Criteria Could Increase Access to, Participation in Clinical Trials
- Continuous Therapy May Be Beneficial in Patients With Newly Diagnosed Multiple Myeloma
- ASCO Convenes Panel to Address Handling of Hazardous Drugs
- Cancer Death Rate in U.S. Decreased Continuously From 1991 to 2016
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