10 percent urea cream superior to new ointment for hand-foot syndrome
the ONA take:
According to a new study published online ahead of print in the Journal of Clinical Oncology, researchers have found that 10% urea cream is superior to a newly introduced ointment containing various antioxidants at preventing hand-foot syndrome during the first 6 weeks of treatment with capecitabine for gastrointestinal or breast cancer.
For the phase III trial, researchers enrolled 152 patients with gastrointestinal tumors or breast cancer who were treated with oral capecitabine. Participants were randomly assigned to receive urea cream or the new ointment, which has been available on the German market since 2011.
Results showed that 30.9% of patients who received the new ointment experienced hand-foot syndrome compared with 22.4% in the urea cream group (OR = 2.37; P=0.02).
Researchers found that time to any-grade hand-foot syndrome was significantly longer in the urea cream arm than the new ointment arm (P=0.03). The study also demonstrated that skin-related quality of life was significantly worse in the new ointment group than the urea group at the end of study treatment.
10% urea cream is superior to a newly introduced ointment containing various antioxidants at preventing hand-foot syndrome.
Sign Up for Free e-newsletters
- Leukemia Risk in Children, Maternal Use of Hormonal Contraception Linked in Population Study
- Molecular Features May Predict Response in Primary Pancreatic Cancer
- Medication, Vaccination Uptake Improved by Involving Pharmacists in Elder Cancer Care
- Commission Seeks Standardized Adverse Event Assessments in Hematologic Malignancies
- Chemoimmunotherapy prolongs PFS in metastatic triple-negative breast cancer
- Navigating Prostate Cancer: A Patient's Experience From Diagnosis to Survivor
- Cell Phones and Cancer Risk (Fact Sheet)
- How Likely Are Oncologists to Refer for Palliative Care? Depends on Their Age
- Use of Corticosteroids With PD-1 or PD-L1 Inhibitors Associated With Poorer Outcomes in NSCLC
- Chemoimmunotherapy Increases Survival in Triple-Negative Breast Cancer
- Counseling Patients on Oral Chemotherapy
- Patients and Caregivers Worry About Cost of Cancer Care
- Stem Cell Transplantation Superior to Chemotherapy for Relapsed/Refractory DLBCL, Follicular Lymphoma
- Head and Neck Cancer Survivors Have Increased Suicide Risk
- Hodgkin Lymphoma Survivorship Marked by Periods of Actionable Distress
Regimen and Drug Listings
GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION
|Head and Neck Cancer||Regimens||Drugs|