10 percent urea cream superior to new ointment for hand-foot syndrome
the ONA take:
According to a new study published online ahead of print in the Journal of Clinical Oncology, researchers have found that 10% urea cream is superior to a newly introduced ointment containing various antioxidants at preventing hand-foot syndrome during the first 6 weeks of treatment with capecitabine for gastrointestinal or breast cancer.
For the phase III trial, researchers enrolled 152 patients with gastrointestinal tumors or breast cancer who were treated with oral capecitabine. Participants were randomly assigned to receive urea cream or the new ointment, which has been available on the German market since 2011.
Results showed that 30.9% of patients who received the new ointment experienced hand-foot syndrome compared with 22.4% in the urea cream group (OR = 2.37; P=0.02).
Researchers found that time to any-grade hand-foot syndrome was significantly longer in the urea cream arm than the new ointment arm (P=0.03). The study also demonstrated that skin-related quality of life was significantly worse in the new ointment group than the urea group at the end of study treatment.
10% urea cream is superior to a newly introduced ointment containing various antioxidants at preventing hand-foot syndrome.
Sign Up for Free e-newsletters
- Is Radioimmunotherapy a Path Forward for Melanoma?
- FDA Approves Mogamulizumab-kpkc for Rare Subtypes of Non-Hodgkin Lymphoma
- New PDL1 Inhibitors for Non-small Cell Lung Cancer: Focus on Pembrolizumab
- Intensive Chemotherapy May Not Be Effective in MDS or AML After MDS
- ASCO Endorses SIO Guideline for Integrative Therapies in Breast Cancer
- Seeking Reliable Information on Herbal Products
- NCCIH HerbList App Launched to Provide Information on Herbal Products
- Metformin Use May Improve Survival Outcomes in Bladder Cancer
- Higher Vitamin D Levels Associated With Lower Breast Cancer Risk
- Nurse-Led Program Improves Health, Financial Outcomes in Outpatient Chemotherapy
- Adhering to Cytoreductive Therapy Use May Improve Outcomes in Polycythemia Vera
- Disparities Remain in Prevalence of Cancer Screening Tests
- Hope, Gratitude, and Spirituality: What They Mean to Cancer Patients
- FDA, EU Approvals Sought for Split Dose Regimen of Daratumumab for Multiple Myeloma
- 8 Hours of Bedrest May Be Ideal After Intrathecal Chemotherapy in Hematologic Cancers
Regimen and Drug Listings
GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION
|Head and Neck Cancer||Regimens||Drugs|