Levofloxacin plus aminoglycoside superior to ciprofloxacin after prostate biopsy

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This study investigated the potential benefit of oral fluoroquinolone prophylaxis in patients undergoing transrectal ultrasound-guided (TUG) prostate biopsy.

The researchers compared two prophylactic antibiotic regimens: one dose of ciprofloxacin 500 mg combined with an aminoglycoside (AG) or one dose of levofloxacin 750 mg combined with an AG.

The ciprofloxacin group involved 535 biopsies, and the levofloxacin 654 biopsies. Total infection rate was 3.18% in the ciprofloxacin group and 2.14% in the levofloxacin group.

The rate of mild infection was 0.75% in the ciprofloxacin group and 1.22% in the levofloxacin group; however, the rate of severe infection was higher in the ciprofloxacin group compared with the levofloxacin group (2.43% vs 0.92%, respectively).

Use of a single dose of fluoroquinolone augmented with an AG is optimal prophylaxis to reduce infectious complications in patients undergoing prostate biopsy.

The researchers found that 750 mg levofloxacin is more effective than 500 mg ciprofloxacin in reducing severe infections in these patients.

Photomicrograph of a Cutaneous Biopsy
Use of single dose of fluoroquinoloneis optimal prophylaxis to reduce infectious complications in patients undergoing prostate biopsy.
To investigate whether there is benefit with a longer acting oral fluoroquinolone, we compared the rate of infection after transrectal ultrasound-guided prostate biopsy between 2 prophylactic antibiotic regimens: ciprofloxacin vs levofloxacin, each combined with an aminoglycoside (AG).
READ FULL ARTICLE From www.goldjournal.net
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