HPV infection found to increase risk of lung cancer

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According to a new study published in the Journal of Clinical Virology, researchers have found that there is a strong association between lung tissue with human papillomavirus (HPV) infection, particularly HPV subtypes 16 and 18, and lung cancer. For the meta-analysis, the researchers searched various databases through March 2014 and identified nine studies that it total included 1,094 lung cancer cases and 484 non-cancer cases.

Statistical analyses showed that HPV infection was associated with lung cancer (Odds Ratio [OR] = 5.67, 95% CI: 3.09-10.40, P <0.001). Researchers also found that HPV subtypes 16 and 18 were similarly associated with lung cancer (OR = 6.02, 95% CI: 3.22-11.28, P <0.001). Furthermore, HPV 16 and 18 were strongly associated with lung squamous cell carcinoma (SCC) (OR = 9.78, 95% CI: 6.28-15.22, P <0.001), which was three times greater than with lung adenocarcinoma (OR = 3.69, 95% CI: 0.99-13.71, P = 0.052).

The findings suggest that HPV subtypes 16 and 18 infection significantly elevates the risk for developing SCC, indicating that there may be causal pathogenesis association between HPV and lung cancer.

HPV vaccination can prevent most cervical cancers.
Researchers have found that there is a strong association between lung tissue with HPV.
The authors performed this meta–analysis to evaluate whether human papillomavirus (HPV) infection in lung tissue is associated with lung cancer (LC) compared with non–cancer controls. Nevertheless, the results suggest that lung tissue with HPV infection has a strong association with LC, and especially, HPV16/18 infection significantly increases squamous cell carcinoma (SCC) risk, which indicates a potential pathogenesis link between HPV and LC.
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