Gene mutation lowers breast cancer survival

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A recent study determined that women with a specific gene mutation have a lower chance of surviving breast cancer. Researchers examined data from a number of studies, which involved more than 2,600 women in several different countries. Protein coding changes for patients with ER– breast cancer were examined, and the researchers accounted for factors such as age at diagnosis and size of tumors involved. Previous research indicated that the body's immune system plays a role in survival, as well as survival being in part inherited, but the exact genes involved had no yet been determined. Now scientists feel that a variant of the CCL20 gene is responsible, and that CCL20 mutations can indeed lower the chances of breast cancer survival. This discovery, published in the journal Nature Communications, would seem to illustrate the importance of targeted therapy and represent CCL20 as a target for tailored therapies.

Gene mutation lowers breast cancer survival
Gene mutation lowers breast cancer survival

Women with a specific gene mutation have a higher risk of dying from a type of breast cancer, said a study Tuesday that raised prospects of targeted drugs.

Previous research had shown that the chances of surviving breast cancer after treatment were partly inherited. It was suspected that genes in the body's immune system were involved, but it was unclear which ones.

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