Common chemicals acting together may be carcinogenic to humans

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Common chemicals not considered to be carcinogenic to humans at low doses may act together to increase cancer risk, according a 3-year investigation conducted by a task force comprised of nearly 200 researchers from 28 countries.

Of the 85 chemicals studied, 50 were found to disrupt normal cell function in ways that are known to be associated with early signs of cancer.

Chemicals studied included bisphenol A (BPA), a chemical used in plastics, rotenone, an insecticide, paraquat, a herbicide, triclosan, an antibacterial agent, and EDTA, a metal-ion-binding compound used in manufacturing and medicine.

"Our findings also suggest these molecules may be acting in synergy to increase cancer activity," said William Bisson, an assistant professor and cancer researcher at OSU and a team leader on the study.

EDTA alone does not cause gene mutations, but when exposed to that and something else that is mutagenic, the effect of DNA repair disruption is enhanced.

The findings suggest that more research is warranted to evaluate early exposure to these common chemicals and how those chemicals affect the early stages of cancer development.

CT scan not necessary to diagnose cancer in patients with unexplained blood clots
Common chemicals not considered to be carcinogenic to humans at low doses may act together to increase cancer risk.
Common environmental chemicals assumed to be safe at low doses may act separately or together to disrupt human tissues in ways that eventually lead to cancer, according to a task force of nearly 200 scientists from 28 countries, including one from Oregon State University.
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