Newly-identified protein may contribute to colon cancer development
the ONA take:
A newly-identified pathway may contribute to the development of colon cancer, according to a study published in PLoS Genetics.
Researchers led by Anil Rustgi, MD, of the Perelman School of Medicine at the University of Pennsylvania conducted a follow-up to a 2013 study that identified the LIN28B protein as a contributor of cancerous growth in intestinal cells through suppression of Let-7 molecules.
In the new study, the researchers created transgenic mice that produced no Let-7 miRNAs in order to better understand their function in preventing cancer.
They found that adenomas adenomatous polyps, as well as adenocarcinomas that resembled human colon tumors, had formed in the intestines of all these mice without Let-7 by mid-adulthood.
Upon analyses of the tumors, they were able to identify a protein called Hmga2 as a major factor in their development. They were able to conclude that within the intestinal lining of the mice without Let-7, Hmga2 gene expression was unusually high.
In order to check the relevance of these findings, the researchers also examined several hundred human colorectal cancer samples and found lower-than-normal Let-7 miRNA as well as higher-than-normal HMGA2 (the human version of the mouse Hmga2 protein) expression.
A newly-identified pathway may contribute to the development of colon cancer.
Sign Up for Free e-newsletters
- Scalp Cooling With Dignicap May Reduce Alopecia During Chemotherapy for Breast Cancer
- Evolution of HER2-Positive Breast Cancer: Yesterday, Today, and Tomorrow
- Dedicated End-of-Life Education Program Improves Nurses' Care, Patient and Family Satisfaction
- Reflexology, Aromatherapy May Reduce Pain, Anxiety of Brachytherapy for Cervical Cancer
- Oncology Extended Care Clinic Reduced Urgent Cancer-Related ED Visits
- Hair Dyes and Cancer Risk (Fact Sheet)
- Taste Changes After Hematopoietic Stem Cell Transplant Affect QOL in Blood Cancers
- Hope, Optimism Reduce Psychological Distress in Advanced Cancer
- Mitomycin Extravasation Protocol
- Accurate Understanding of Capacity May Improve Workflow, Efficiency in Infusion Suite
- Nursing Practice Change Improved Chemo Administration, But Old Habits Die Hard
- Simple Adjustment Key to Paclitaxel Infusion Protocol That Reduced Hypersensitivity Reactions
- Online Program Aims to Assist With Clinical Trial Enrollment for Hematologic Cancers
- Education May Better Equip Nurses to Hold End-of-Life Conversations in Advanced Cancer
- Skipping the SICU Post Head and Neck Cancer Surgery May Improve Outcomes
Regimen and Drug Listings
GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION
|Head and Neck Cancer||Regimens||Drugs|