Brain development gene implicated in kidney cancer

Share this content:

the ONA take:

The gene NPTX2, responsible for brain development, has been identified as playing a role in the promotion of renal cell carcinoma. In addition to triggering the most common form of kidney cancer, the protein has been identified as being present in other cancers and may play a role there as well.

Researchers affiliated with the Mayo Clinic in Florida utilized kidney cancer sample data from almost 100 patients, using genomic profiling to identify genes in the samples that were abnormally expressed when compared to healthy kidney samples. After various genes were individually ruled out, thirty one genes were deemed to play a role in kidney cancer development and NPTX2 played a particularly strong function in enabling tumor growth. NPTX2 was present at all stages of cancer development, especially metastasis. The study authors also found a receptor called GluR4 in the kidney cancer samples that is typically targeted by the  NPTX2 protein in the brain. In kidney cancer, the over-expressed NPTX2 protein attaches to GluR4 via the kidney cancer cell membrane, enabling metastasis. The effect of NPTX2 is to stimulate grouping of GluR4 proteins, which allows calcium to enter the cell. The heightened calcium, in turn, triggers signaling pathways that encourage cancer incursion and metastasis.

Brain development gene implicated in kidney cancer
Brain development gene implicated in kidney cancer

A gene known to control brain growth and development is heavily involved in promoting clear cell renal cell carcinoma, the most common form of kidney cancer, researchers from Mayo Clinic in Florida are reporting.
Their study, published in Cancer Research, reveals that the gene NPTX2, plays an essential role in this cancer type, which is resistant to common chemotherapy and has a five-year overall survival rate of less than 10 percent in patients with metastatic disease.
READ FULL ARTICLE From Biosciencetechnology
You must be a registered member of ONA to post a comment.

Sign Up for Free e-newsletters

Regimen and Drug Listings


Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Genitourinary Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Rare Cancers Regimens
Skin Cancer Regimens Drugs