BPA stimulates breast cancer cells growth

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Environmental exposure to the chemical bisphenol A (BPA) appears to lower the effectiveness of a targeted anti-cancer drug for inflammatory breast cancer, as well as cause an increase to breast cancer cell reproduction. 

Research presented by Duke University Research Center scientists at the joint meeting of the International Society of Endocrinology and the Endocrine Society (ICE/ENDO 2014) presented data that the efficacy of anti-cancer drugs used in breast cancer therapy is decreased by the presence of BPA in the bloodstream. The drug lapatinib was one of the tested breast cancer drugs that showed such a reaction. Research also showed that bisphenol A, still found in many consumer goods, can be tied to increased production of inflammatory breast cancer cells. Principal investigator, Gayathri Devi, PhD, and colleagues examined the tumors from patients with breast cancer, subjecting them to doses of BPA in order the record the results. A range or both exposure levels and exposure durations were reviewed. Both estrogen-receptor positive and estrogen-receptor negative breast cancer cells reacted when exposed to BPA.

BPA stimulates breast cancer cells growth
BPA stimulates breast cancer cells growth
DURHAM, N.C. – Bisphenol A (BPA), a chemical commonly used in plastics, appears to increase the proliferation of breast cancer cells, according to Duke Medicine researchers presenting at an annual meeting of endocrine scientists.The researchers found that the chemical, at levels typically found in human blood, could also affect growth of an aggressive hormone-independent subtype of breast cancer cells called inflammatory breast cancer and diminish the effectiveness of treatments for the disease.
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