Antibiotic use was associated with increased risk for some cancers

Share this content:

the ONA take:

Recurrent exposure to antibiotics may increase the risk for cancer in specific organ sites, according to a recent report published in the European Journal of Cancer.

A large population-based electronic medical record database was used to conduct nested case-control studies for 15 common malignancies. Persons with inherited cancer syndromes were excluded. Four eligible matched controls were selected for every case. In total, 125,441 cases and 490,510 matched controls were analyzed.

The findings demonstrated use of penicillin was associated with higher risk of some GI cancers, and this association was higher for those who underwent more antibiotic courses.

Penicillin, cephalosporins, or macrolides use was associated with higher risk for lung cancer; penicillin, quinolones, sulphonamides, and tetracyclines were associated with moderately increased risk for prostate cancer; and sulphonamides were modestly associated with risk for breast cancer. However, no association was found with the use of antivirals and antifungals.

A common antibiotic may be part of the key to fighting pancreatic cancer.
Recurrent exposure to antibiotics may increase the risk for cancer in specific organ sites.
Bacterial dysbiosis was previously described in human malignancies. In a recent animal model, tumour susceptibility was transmitted using faecal transplantation. Our aim was to evaluate possible association between antibiotic exposure and cancer risk.
You must be a registered member of ONA to post a comment.

Sign Up for Free e-newsletters

Regimen and Drug Listings


Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Genitourinary Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Rare Cancers Regimens
Skin Cancer Regimens Drugs