ADD THIS DRUG TO MY LIST

Select the drug indication to add to your list

GLUCOPHAGE XR
Diabetes
Compare To Related Drugs
View/Edit/Compare Drugs In My List

Only 4 drugs may be compared at once

Drug Name:

GLUCOPHAGE XR Rx

Generic Name and Formulations:
Metformin HCl 500mg, 750mg; ext-rel tabs.

Company:
Bristol-Myers Squibb

Therapeutic Use:

Indications for GLUCOPHAGE XR:

Adjunct to diet and exercise in type 2 diabetes.

Adult:

Swallow whole. Take with evening meal. Individualize. ≥17yrs: initially 500mg once daily; may increase by 500mg increments at 1-week intervals; max 2g once daily or in 2 divided doses. If higher doses needed, switch to Glucophage at max 2.55g/day in divided doses.

Children:

<17yrs: not established. Use immediate-release form.

Contraindications:

Severe renal impairment (eGFR <30mL/min/1.73m2). Metabolic acidosis, diabetic ketoacidosis.

Boxed Warning:

Lactic acidosis.

Warnings/Precautions:

Increased risk of metformin-associated lactic acidosis in renal or hepatic impairment, concomitant use of certain drugs (eg, carbonic anhydrase inhibitors), ≥65yrs of age, undergoing radiological contrast study, surgery and other procedures, hypoxic states, and excessive alcohol intake; discontinue if lactic acidosis occurs. Discontinue at time of, or prior to intravascular iodinated contrast imaging in patients with eGFR 30–60mL/min/1.73m2, history of hepatic impairment, alcoholism, heart failure, or will be given intra-arterial contrast; reevaluate eGFR 48hrs after procedure and restart therapy if renally stable. Suspend therapy if dehydration occurs or before surgery. Avoid if evidence of hepatic disease. Assess renal function prior to starting and periodically thereafter; more frequently in elderly or patients whose eGFR falls <45mL/min/1.73m2; see full labeling. Monitor hematology (esp. serum Vit. B12 in susceptible patients). Pregnancy. Nursing mothers.

See Also:

GLUCOPHAGE

Pharmacological Class:

Biguanide.

Interactions:

Increased risk of lactic acidosis with topiramate, other carbonic anhydrase inhibitors (eg, zonisamide, acetazolamide, dichlorphenamide); monitor. Concomitant cationic drugs that interfere with renal tubular transport systems (eg, ranolazine, vandetanib, dolutegravir, cimetidine) may increase metformin levels; monitor. Avoid excessive alcohol intake (potentiates effects of metformin on lactate). Diuretics, steroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, sympathomimetics, calcium channel blockers, isoniazid, nicotinic acid, others may cause hyperglycemia. May need lower dose of concomitant insulin and/or insulin secretagogue (eg, sulfonylurea) to reduce risk of hypoglycemia.

Adverse Reactions:

Diarrhea, nausea, vomiting, flatulence, asthenia, indigestion, abdominal discomfort, headache; rare: lactic acidosis (may be fatal).

How Supplied:

XR tabs—100; Tabs 500mg—100, 500; 850mg, 1000mg—100

Sign Up for Free e-newsletters



Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Genitourinary Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Rare Cancers Regimens
Skin Cancer Regimens Drugs