Genetic Testing

Molecular Features May Predict Response in Primary Pancreatic Cancer 

Molecular Features May Predict Response in Primary Pancreatic Cancer 

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The goal of this study was to determine how molecular features change when PDAC progresses from a primary tumor to metastatic disease.

Barriers to Prostate Cancer Research in Black Men Identified

Barriers to Prostate Cancer Research in Black Men Identified

Mistrust, lack of knowledge, unfavorable attitudes are barriers to genomic testing, study participation

Frequency of Reclassifications of Genetic Testing Results Is Low

Frequency of Reclassifications of Genetic Testing Results Is Low

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A retrospective analysis of genetic testing results at one laboratory reports that reclassifications occurs in approximately one-quarter of tests, resulting in both downgrades and upgrades of variant classifications.

Benefit of Chemotherapy for Breast Cancer Observed With Midrange Gene Assay Score

Benefit of Chemotherapy for Breast Cancer Observed With Midrange Gene Assay Score

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In a randomization of women with early-stage breast cancer, researchers explored the potential benefits of chemotherapy for women whose Oncotype DX RS was midrange.

Genetic Susceptibility to Pancreatic Cancer Linked to 6 Specific Gene Mutations

Genetic Susceptibility to Pancreatic Cancer Linked to 6 Specific Gene Mutations

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Investigators conducted a case-control study of 3030 pancreatic cancer patients in an attempt to confirm which genes might render patients susceptible to pancreatic cancer.

Patient Interest in Melanoma Genetic Risk Testing is Fairly High

Patient Interest in Melanoma Genetic Risk Testing is Fairly High

Researchers examined interest in MC1R testing in the general population and assessed patterns across demographic and skin cancer risk factors.

Direct-to-Consumer Genetic Test for Select <i>BRCA</i> Mutations Gets FDA Nod

Direct-to-Consumer Genetic Test for Select BRCA Mutations Gets FDA Nod

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The US FDA has approved a consumer test that may indicate increased breast and ovarian cancer risk in some individuals.

Awareness of Genomic Risk for Melanoma May Increase Conversations With Family, Health Care Providers

Awareness of Genomic Risk for Melanoma May Increase Conversations With Family, Health Care Providers

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Awareness of personal genetic risk for melanoma may prompt patients to discuss cancer risk with family and health care professionals, and make lifestyle changes.

Bilateral Mastectomy Without Proper Genetic Counseling

Bilateral Mastectomy Without Proper Genetic Counseling

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Many women with breast cancer with genetic variants of uncertain significance (VUS) undergo testing and bilateral mastectomy without receiving genetic counseling.

Counseling Regarding Genetic Testing in Breast Cancer Lacking, Yet Many Still Undergo BLM

Counseling Regarding Genetic Testing in Breast Cancer Lacking, Yet Many Still Undergo BLM

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Many women with breast cancer with genetic VUS undergo testing and bilateral mastectomy (BLM) without ever receiving genetic counseling.

Personalized Medicine and the Role of the Oncology Navigator

Personalized Medicine and the Role of the Oncology Navigator

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As molecular testing becomes the standard of care for many cancers, nurse navigators have an important role to play ensuring molecular testing of suitable patients, providing patient education, and managing of patient expectations.

Better Understanding of Prostate Cancer Genetic Test Results Needed

Better Understanding of Prostate Cancer Genetic Test Results Needed

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Some men who undergo multigene testing for inherited prostate cancer misinterpret findings of variants of uncertain significance.

Novel Approach Increases Breast, Ovarian Cancer Genetic Screening

Novel Approach Increases Breast, Ovarian Cancer Genetic Screening

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A questionnaire added to intake forms at a breast cancer imaging center identified women with BRCA mutations who might otherwise have been missed.

Genome-Informed Treatment Improves Survival in Pancreatic Cancer

Genome-Informed Treatment Improves Survival in Pancreatic Cancer

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Precision Medicine Improves Pancreatic Cancer Treatment

Whole Genome Sequencing Reveals that 12% of Childhood Cancer Survivors Have Mutations in Genes that Increase Cancer Risk

Whole Genome Sequencing Reveals that 12% of Childhood Cancer Survivors Have Mutations in Genes that Increase Cancer Risk

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Whole genome sequencing of more than 3000 survivors of childhood cancers demonstrates the value of genetic testing for potential second cancers in this population.

Noninvasive 2-Gene Test Helps Distinguish Melanoma From Nonmelanoma

Noninvasive 2-Gene Test Helps Distinguish Melanoma From Nonmelanoma

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Two-gene pigmented lesion test classifies skin lesions as melanoma or nonmelanoma, helping with diagnostic challenges faced with the visual image and pattern recognition approach.

Outcomes Improved When Targeted Cancer Therapies Based on Multigene Panel

Outcomes Improved When Targeted Cancer Therapies Based on Multigene Panel

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Progression-free survival rates are higher in patients treated with targeted therapies based on results of multigene panel tests.

Trends in BRCA Mutation Testing Shifting Toward Unaffected Women

Trends in BRCA Mutation Testing Shifting Toward Unaffected Women

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Genetic testing for BRCA gene mutation is increasingly undertaken by women unaffected by breast and/or ovarian cancers.

Comparing Popular Commercial Cancer Gene Tests Yield Different Results

Comparing Popular Commercial Cancer Gene Tests Yield Different Results

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A head-to-head comparison of two commercial gene sequencing tests yielded differing results.

Novel Pathway Improves Access to Genetic Testing for Women With Ovarian Cancer

Novel Pathway Improves Access to Genetic Testing for Women With Ovarian Cancer

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Rapid, robust, and affordable genetic testing for patients with ovarian cancer that allows a much larger portion of patients to benefit from personalized cancer management and their relatives to benefit from preventive strategies can be achieved.

Study Finds Racial Disparities in Breast and Ovarian Cancer Risk Management

Study Finds Racial Disparities in Breast and Ovarian Cancer Risk Management

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Disparities in cancer risk management among BRCA carriers across a diverse sample of young black, Hispanic, and non-Hispanic white breast cancer survivors underscores that "the benefit from genetic testing comes from acting on the test results," not just the testing itself, a study presented at the ASCO 2016 Annual Meeting concluded.

Participants Understand Implications of Multiplex Gene Testing for Inherited Cancer Risk

Participants Understand Implications of Multiplex Gene Testing for Inherited Cancer Risk

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Multiplex gene testing of diverse patients has found that patients who test positive advise relatives to test, "suggesting that participants understood the implications of test results," according to results of a planned interim analysis of a prospective trial presented at the ASCO 2016 Annual Meeting.

Large Germline Databases Needed to Mitigate Ethnic Disparities

Large Germline Databases Needed to Mitigate Ethnic Disparities

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"In the absence of patient-matched germline data, large germline databases are required in analysis workflows to minimize false positive mutation calling and mitigate ethnic disparities," a study presented at the ASCO 2016 Annual Meeting concluded.

Telephone Disclosure of Genetic Tests for Cancer Susceptibility Can Increase Satisfaction

Telephone Disclosure of Genetic Tests for Cancer Susceptibility Can Increase Satisfaction

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Results showed that telephone disclosure was not worse than in-person disclosure for general and state anxiety.

No Clinical Benefit to Expanding Gene Panel Beyond Ovarian and Breast Cancer Genes in High-risk Women

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Expanding a panel of tested genes beyond the known breast and ovarian cancer-specific genes in patients with breast and ovarian cancer did not confer any clinical benefit.

Gene Test Identifies Patients With Breast cancer That Do Not Need Chemotherapy

Gene Test Identifies Patients With Breast cancer That Do Not Need Chemotherapy

An analysis of test results can help women who won't benefit from additional treatment avoid potential side effects.

Genetic Testing for BRCA Gene Mutations Increasing Among Younger Women With Breast Cancer

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Among women age 40 years or younger, rates of genetic testing for BRCA1 and BRCA2 mutations have increased, according to a recent study.

Young patients with HER2+ breast cancer and no family history have low risk of carrying high risk genes

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A recent study examined genetic susceptibility in younger patients diagnosed with HER2+ breast cancer.

Stool DNA Test Is Proven an Accurate Screen for Colorectal Cancer in a High-Risk Population

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A stool DNA test for colorectal cancer was found to be an accurate noninvasive screening option for Alaska Native people, a population with one of the highest rates of colorectal cancer in the world, according to a recent study.

Blood Test Can Guide Treatment Sequencing for Pancreatic Cancer

Blood Test Can Guide Treatment Sequencing for Pancreatic Cancer

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A widely available, inexpensive blood test can predict outcomes and guide treatment in pancreatic cancer; however, only 1 in 5 US patients with the disease have the blood test.

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