Recent data suggest that epigenetic therapies are likely to provide additional clinical benefit to patients with cancer when rationally combined with immunotherapeutic drugs.
Researchers have identified the signaling pathway that is overactivated in estrogen receptor (ER)-positive breast cancer cells that are resistant to hormone therapies such as tamoxifen, aromatase inhibitors, or fulvestrant.
A new study of neoadjuvant cisplatin-based chemotherapy showed that epigenetic changes are potential key drivers in the development of chemotherapy resistance in bladder cancer.
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