Inborn errors of metabolism:
Indications for: ZEMAIRA
For chronic augmentation and maintenance therapy in adults with alpha1-proteinase inhibitor (A1-PI) deficiency and clinical evidence of emphysema.
Adult Dosage:
Give by IV infusion at a rate of 0.08mL/kg/min. 60mg/kg once weekly. Monitor infusion rates and clinical state closely during infusion. Reduce rate or discontinue if adverse reactions occur; resume at lower rate if subside.
Children Dosage:
Not established.
ZEMAIRA Contraindications:
History of anaphylaxis or severe systemic response to A1-PI products. IgA deficiencies with known antibodies against IgA.
ZEMAIRA Warnings/Precautions:
Not for lung disease where severe A1-PI deficiency has not been established. Monitor for hypersensitivity reactions; discontinue immediately if anaphylaxis or severe reactions occur. Have epinephrine and other supportive therapy readily available. Contains human plasma; monitor for possible infection transmission (eg, viruses, Creutzfeldt-Jakob disease). Pregnancy. Nursing mothers.
Adverse Reactions:
Headache, sinusitis, upper respiratory infection, bronchitis, asthenia, cough increased, fever, inj site hemorrhage, rhinitis, sore throat, vasodilation; hypersensitivity reactions.
How Supplied:
Single-use vial—1 (w. diluent + filter transfer set)
