Viral infections:
Indications for: TROGARZO
In combination with other antiretroviral(s) for HIV-1 infection in heavily treatment-experienced adults with multidrug resistant HIV-1 infection failing their current antiretroviral regimen.
Adult Dosage:
Give as IV infusion over ≥30mins for 1st infusion. May give subsequent maintenance doses as an IV infusion over ≥15mins or as an IV push over a 30-second period if no infusion-associated adverse reactions have occurred. 2000mg as a single loading dose administered as a diluted IV infusion, followed by 800mg (maintenance dose) every 2 weeks administered either as a diluted IV infusion or undiluted IV push.
Children Dosage:
Not established.
TROGARZO Warnings/Precautions:
Discontinue immediately if hypersensitivity reactions (including infusion-related or anaphylactic reactions) occur; treat appropriately. Immune reconstitution inflammatory syndrome (in combination with other antiretrovirals). Embryo-fetal toxicity. Pregnancy: may affect immune responses in infants exposed in utero; monitor for reversible immunosuppression; do immune phenotyping and consult expert. Nursing mothers: not recommended.
TROGARZO Classification:
CD4-directed post-attachment HIV-1 inhibitor.
Adverse Reactions:
Diarrhea, dizziness, nausea, rash; lab abnormalities.
Note:
To register pregnant patients to the Antiretroviral Pregnancy Registry, call (800) 258–4263.
Generic Drug Availability:
NO
How Supplied:
Single-dose vials (2mL)—2
