Arthritis/rheumatic disorders:

Indications for: SYNVISC ONE

Treatment of pain in osteoarthritis of the knee in patients who have failed to respond adequately to conservative nonpharmacologic therapy and simple analgesics (eg, acetaminophen).

Adult Dosage:

Remove synovial fluid or effusion before inj. Give as a single intra-articular inj. 6mL in one knee only.

Children Dosage:

Not recommended.

SYNVISC ONE Contraindications:

Knee joint infections. Skin diseases or infections in area of the inj site.

SYNVISC ONE Warnings/Precautions:

Avian protein, feathers, or egg allergy. Severely inflamed knee joints. Lymphatic or venous stasis in leg. Advise patients to avoid strenuous activities for approx. 48 hrs following inj. Pregnancy, nursing mothers: not established.

SYNVISC ONE Classification:

Hyaluronan derivative.

SYNVISC ONE Interactions:

Avoid use of disinfectants containing quaternary ammonium salts; hyaluronan can precipitate in their presence. Concomitant other intra-articular inj: not studied.

Adverse Reactions:

Arthralgia, arthritis, arthropathy, inj site pain, gait disturbance; joint effusion, stiffness, swelling, warmth, pain.

Generic Drug Availability:


How Supplied:

Single-use syringe—1