Indications for SULAR:
Swallow whole. Take on an empty stomach (1hr before or 2hrs after a meal). Initially 17mg once daily; may increase by 8.5mg per week or longer intervals. Usual maintenance: 17–34mg once daily; max 34mg/day. Hepatic impairment or elderly (>65yrs): Initially 8.5mg once daily.
Coronary artery disease. Heart failure or compromised ventricular function (esp. with a beta-blocker). Monitor BP closely during initiation and titration. Severe hepatic impairment. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.
Calcium channel blocker (CCB) (dihydropyridine).
Avoid concomitant CYP3A4 inhibitors or inducers, grapefruit juice. High-fat meals increase peak drug concentrations. Antagonized by phenytoin (avoid; consider alternatives). May be potentiated by cimetidine.
Peripheral edema, headache, dizziness, pharyngitis, vasodilation, sinusitis, palpitations, chest pain, nausea, rash; increased angina, MI (rare), hypotension.