MAVYRET ORAL PELLETS Rx

<3yrs: not established. Test for HBV infection prior to initiation. Take with food. Sprinkle contents of oral pellets on soft food with a low water content, then swallow whole (eg, peanut butter, chocolate hazelnut spread, cream cheese, thick jam, Greek yogurt). ≥3yrs (<20kg): 150mg/60mg (pellets) once daily; (20–<30kg): 200mg/80mg (pellets) once daily; (30–<45kg): 250mg/100mg (pellets) once daily; (≥45kg or ≥12yrs): 300mg/120mg (tabs or give pellets if unable to swallow) once daily. Treatment-naive: treat for 8 weeks. Treatment-experienced (genotype 1): treat for 16 weeks if previously treated with an NS5A inhibitor (without prior NS3/4A protease inhibitor) or for 12 weeks if previously treated with an NS3/4A protease inhibitor (without prior NS5A inhibitor); (genotypes 1, 2, 4, 5, 6): treat for 8 weeks (no cirrhosis) or 12 weeks (compensated cirrhosis) if previously treated with regimens containing PEG-IFN, ribavirin, and/or sofosbuvir, but no prior treatment with an HCV NS3/4A protease inhibitor or NS5A inhibitor; (genotype 3): treat for 16 weeks if previously treated with regimens containing PEG-IFN, ribavirin, and/or sofosbuvir, but no prior treatment with an HCV NS3/4A protease inhibitor or NS5A inhibitor. HCV/HIV-1 co-infected with or without compensated liver disease or renal impairment including on hemodialysis: follow same dosage regimen. Liver or kidney transplant: treat for 12 weeks; (genotype 1): treat for 16 weeks if NS5A inhibitor-experienced (without prior NS3/4A protease inhibitor); (genotype 3): treat for 16 weeks if prior treatment experience with regimens containing PEG-IFN, ribavirin, and/or sofosbuvir; see full labeling.