Diabetes:

Indications for GVOKE:

Severe hypoglycemia.

Adults and Children:

<2yrs: not established. Give by SC inj into lower abdomen, outer thigh, or outer upper arm. May repeat after 15mins if no response. 2–<12yrs (<45kg): 0.5mg; (≥45kg): 1mg. ≥12yrs: 1mg.

Contraindications:

Pheochromocytoma. Insulinoma.

Warnings/Precautions:

Previously undiagnosed pheochromocytoma. Conditions with insufficient hepatic glycogen (eg, starvation, adrenal insufficiency, chronic hypoglycemia); treat with glucose. Necrolytic migratory erythema (due to continuous infusion). Glucagonoma: if suspected, test prior to initiation and monitor during therapy. Pregnancy. Nursing mothers.

Pharmacologic Class:

Antihypoglycemic.

Interactions:

May cause transient increase in BP and pulse with β-blockers. Antagonized by indomethacin. May potentiate warfarin.

Adverse Reactions:

Adults: nausea, vomiting, inj site edema raised ≥1mm, headache; children: nausea, hypoglycemia, vomiting, headache, abdominal pain, hyperglycemia, inj site discomfort and reaction, urticaria; allergic reactions.

Generic Availability:

NO

How Supplied:

Prefilled syringes (PFS)—1, 2; HypoPen autoinjectors—2

Pricing for GVOKE

2 PFS syringes of 1mg/0.2ml carton (Qty: 1)
Appx. price $582
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