Indications for GONITRO:
Acute relief of angina attack. Acute prophylaxis of angina pectoris.
Treatment: 1 or 2 packets (400mcg/packet) sublingually at onset, may give 1 additional packet every 5 mins as needed; max 3 packets in 15 mins. Prophylaxis: 5–10 mins before activity.
Concomitant PDE-5 inhibitors (eg, avanafil, sildenafil, tadalafil, vardenafil), soluble guanylate cyclase stimulators (eg, riociguat). Severe anemia. Increased intracranial pressure. Acute circulatory failure or shock.
Hypotensive (constrictive pericarditis, aortic or mitral stenosis) or volume depleted. Hypertrophic obstructive cardiomyopathy. Use lowest effective dose. Elderly. Pregnancy. Nursing mothers.
See Contraindications. Hypotension potentiated by PDE-5 inhibitors, riociguat, antihypertensives, beta-adrenergic blockers, calcium channel blockers. Potentiated by high-dose aspirin. May antagonize tissue-type plasminogen activators (t-PA). Avoid ergotamine and related drugs; monitor if unavoidable.
Headache, dizziness, paresthesia, hypotension.
Pwd pkts—12, 36, 96