Angina:
Indications for GONITRO:
Acute relief of angina attack. Acute prophylaxis of angina pectoris.
Adult:
Treatment: 1 or 2 packets (400mcg/packet) sublingually at onset, may give 1 additional packet every 5 mins as needed; max 3 packets in 15 mins. Prophylaxis: 5–10 mins before activity.
Children:
Not established.
Contraindications:
Concomitant PDE-5 inhibitors (eg, avanafil, sildenafil, tadalafil, vardenafil), soluble guanylate cyclase stimulators (eg, riociguat). Severe anemia. Increased intracranial pressure. Acute circulatory failure or shock.
Warnings/Precautions:
Hypotensive (constrictive pericarditis, aortic or mitral stenosis) or volume depleted. Hypertrophic obstructive cardiomyopathy. Use lowest effective dose. Elderly. Pregnancy. Nursing mothers.
Pharmacologic Class:
Nitrate.
Interactions:
See Contraindications. Hypotension potentiated by PDE-5 inhibitors, riociguat, antihypertensives, beta-adrenergic blockers, calcium channel blockers. Potentiated by high-dose aspirin. May antagonize tissue-type plasminogen activators (t-PA). Avoid ergotamine and related drugs; monitor if unavoidable.
Adverse Reactions:
Headache, dizziness, paresthesia, hypotension.
Generic Availability:
NO
How Supplied:
Pwd pkts—12, 36, 96
