Indications for: DYRENIUM


Adult Dosage:

Take after meals. Initially 100mg twice daily; max 300mg daily.

Children Dosage:

Not recommended.

DYRENIUM Contraindications:

Concomitant K+ supplements, K+-sparing diuretics, salt substitutes. Hyperkalemia. Anuria. Renal impairment. Severe hepatic disease.

DYRENIUM Warnings/Precautions:

Diabetes. Severely ill. Acidosis predisposition. Electrolyte imbalance. History of renal stones. Gout. Hepatic impairment. Monitor blood, electrolytes, hepatic and renal function frequently. Discontinue if serum potassium >5.5mEq/L or renal values progress. ECG changes or arrhythmias require prompt treatment. Elderly. Pregnancy (Cat.B). Nursing mothers: not recommended.

DYRENIUM Classification:

Diuretic (K+ sparing).

DYRENIUM Interactions:

Avoid K+-sparing diuretics, K+ supplements, and K+ containing salt substitutes. Lithium toxicity. Hyperkalemia more likely with ACE inhibitors. Hyponatremia with sulfonylureas. Acute renal failure with NSAIDs. Adjust antidiabetic medications. Potentiates antihypertensives, nondepolarizing muscle relaxants, anesthetics.

Adverse Reactions:

Rarely: anaphylaxis, rash, photosensitivity, hyper- or hypokalemia, azotemia, renal stones, acute interstitial nephritis, jaundice, GI upset, electrolyte disturbances, blood dyscrasias, weakness, fatigue, dizziness, dry mouth.

How Supplied: