Edema:
Indications for: DYRENIUM
Edema.
Adult Dosage:
Take after meals. Initially 100mg twice daily; max 300mg daily.
Children Dosage:
Not recommended.
DYRENIUM Contraindications:
Concomitant K+ supplements, K+-sparing diuretics, salt substitutes. Hyperkalemia. Anuria. Renal impairment. Severe hepatic disease.
DYRENIUM Warnings/Precautions:
Diabetes. Severely ill. Acidosis predisposition. Electrolyte imbalance. History of renal stones. Gout. Hepatic impairment. Monitor blood, electrolytes, hepatic and renal function frequently. Discontinue if serum potassium >5.5mEq/L or renal values progress. ECG changes or arrhythmias require prompt treatment. Elderly. Pregnancy (Cat.B). Nursing mothers: not recommended.
DYRENIUM Classification:
Diuretic (K+ sparing).
DYRENIUM Interactions:
Avoid K+-sparing diuretics, K+ supplements, and K+ containing salt substitutes. Lithium toxicity. Hyperkalemia more likely with ACE inhibitors. Hyponatremia with sulfonylureas. Acute renal failure with NSAIDs. Adjust antidiabetic medications. Potentiates antihypertensives, nondepolarizing muscle relaxants, anesthetics.
Adverse Reactions:
Rarely: anaphylaxis, rash, photosensitivity, hyper- or hypokalemia, azotemia, renal stones, acute interstitial nephritis, jaundice, GI upset, electrolyte disturbances, blood dyscrasias, weakness, fatigue, dizziness, dry mouth.
How Supplied:
Caps—100
