Hyperacidity, GERD, and ulcers:

Indications for: Dicyclomine

Irritable bowel syndrome.

Adult Dosage:

Initially 20mg 4 times daily; after 1 week may increase to 40mg 4 times daily if tolerated. Discontinue if not effective within 2 weeks or daily doses ≥80mg are not tolerated.

Children Dosage:

<6mos: see Contraindications. ≥6mos: consult manufacturer.

Dicyclomine Contraindications:

Glaucoma. Unstable cardiovascular status. GI or urinary tract obstruction. Severe ulcerative colitis. Myasthenia gravis. Reflux esophagitis. Children <6months of age. Nursing mothers.

Dicyclomine Warnings/Precautions:

Inj: avoid IV administration (may cause thrombosis, inj site reactions). Autonomic neuropathy. Hepatic or renal impairment. Cardiovascular disease. Hypertension. Hyperthyroidism. Salmonella dysentery. Toxic megacolon. Ulcerative colitis. GI or GU obstruction. High environmental temperature. Diarrhea. Elderly. Debilitated. Pregnancy (Cat.B).

See Also:

Dicyclomine Classification:

Anticholinergic.

Dicyclomine Interactions:

Antacids may inhibit absorption; avoid. May antagonize anti-glaucoma agents or drugs that alter GI motility (eg, metoclopramide). Antagonized by agents used to treat achlorhydria and those used to test gastric secretion. Additive anticholinergic effects with other anticholinergics, narcotic analgesics, type I antiarrhythmics, antihistamines, antipsychotics, tricyclics, amantadine, benzodiazepines, MAOIs, nitrites, nitrates, sympathomimetics. May affect absorption of sust rel dosage forms.

Adverse Reactions:

Dizziness, dry mouth, blurred vision, nausea, somnolence, asthenia, and nervousness; cardiovascular and CNS symptoms (eg, psychosis, delirium). Fatal reactions have occurred in infants.

Note:

Formerly known under the brand name Bentyl.

How Supplied:

Caps, tabs, syrup—contact supplier; Amps (2mL)—5