Indications for Cyclobenzaprine HCl Tablets:
Relief of acute muscle spasm, as adjunct to rest and physical therapy.
≥15yrs: initially 5mg 3 times daily, may increase to 10mg 3 times daily; max 2–3 weeks. Elderly or mild hepatic impairment: initially 5mg and then titrate slowly upward.
<15yrs: not established.
Cyclobenzaprine HCl Tablets Contraindications:
Acute post-MI. Arrhythmias, heart block, other conduction disturbances. CHF. Hyperthyroidism. During or within 14 days of MAOIs.
Cyclobenzaprine HCl Tablets Warnings/Precautions:
Moderate-to-severe hepatic impairment: not recommended. Urinary retention. Glaucoma. Increased intraocular pressure. Elderly. Pregnancy (Cat.B). Nursing mothers.
Cyclobenzaprine HCl Tablets Classification:
Muscle relaxant (central).
Cyclobenzaprine HCl Tablets Interactions:
See Contraindications. Hypertensive crisis with MAOIs. Increased risk of serotonin syndrome with other serotonergic drugs (eg, SSRIs, SNRIs, tricyclic antidepressants, tramadol, bupropion, meperidine, verapamil, or MAOIs); monitor closely. Potentiates anticholinergics, alcohol, other CNS depressants. May antagonize guanethidine, clonidine. Tramadol increases seizure risk.
Drowsiness, dry mouth, dizziness, fatigue, headache, GI upset, asthenia, irritability, nervousness, blurred vision, confusion, arrhythmias, tachycardia, hypotension.
Formerly known under the brand names Flexeril, Fexmid.