Hypertension:

Indications for CORZIDE:

Hypertension.

Adult:

Initially 40mg/5mg once daily; may increase to 80mg/5mg once daily. Renal impairment: increase dosing interval (see full labeling).

Children:

Not established.

Contraindications:

Asthma. Sinus bradycardia. 2nd- or 3rd-degree AV block. Overt heart failure. CHF. Cardiogenic shock. Anuria. Sulfonamide allergy.

Boxed Warning:

Exacerbation of ischemic heart disease following abrupt withdrawal.

Warnings/Precautions:

Ischemic heart disease. Bronchospastic disease, COPD. Renal or hepatic dysfunction. Gout. Diabetes. Postsympathectomy. Hyperthyroidism. Monitor electrolytes, renal function. Surgery. SLE. Avoid abrupt cessation. Pregnancy (Cat.C). Nursing mothers: not recommended.

Pharmacologic Class:

Noncardioselective beta-blocker + diuretic.

Interactions:

Hypotension with alcohol, CNS depressants, MAOIs, prazosin, other antihypertensives. Bradycardia with catecholamine-depleting drugs. Adjust antidiabetic, anticoagulant medication. ACTH, amphotericin B, corticosteroids increase hypokalemia risk. May increase toxicity of diazoxide, digitalis, lithium, verapamil, lidocaine. Antagonized by NSAIDs. Antagonizes methenamine, antigout drugs. May block epinephrine. May interfere with glaucoma, parathyroid screening tests.

Adverse Reactions:

Cardiac failure, bronchospasm, bradycardia, heart block, fatigue, fluid and electrolyte imbalance, orthostatic hypotension, GI upset, dizziness, blurred vision, cold extremities, rash, pruritus, blood dyscrasias.

How Supplied:

Tabs—100

Pricing for CORZIDE

40mg/5mg tablet (Qty: 30)
Appx. price $106
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