Colorectal disorders:
Indications for CANASA:
Mild-to-moderately active ulcerative proctitis.
Adult:
Retain supp in rectum for at least 1–3hrs. 1g once daily at bedtime. Treat for 3–6 weeks.
Children:
Not established.
Warnings/Precautions:
Sulfasalazine or aspirin allergy. Renal or hepatic impairment. Evaluate renal function before starting and periodically during therapy. Monitor for acute intolerance syndrome; discontinue if suspected. May stain clothes. Elderly. Pregnancy. Nursing mothers.
Pharmacologic Class:
Aminosalicylate.
Interactions:
Concomitant nephrotoxic agents (eg, NSAIDs) may increase risk of renal effects; monitor. Concomitant azathioprine or 6-mercaptopurine may increase risk of blood disorders; if unavoidable, monitor CBCs and platelets. May interfere with measurements by liquid chromatography of urinary normetanephrine; consider other alternative assay.
Adverse Reactions:
Dizziness, rectal pain, fever, rash, acne, colitis, headache, flatulence, abdominal pain, diarrhea, nausea; mesalamine-induced acute intolerance syndrome, hypersensitivity reactions (including myocarditis, pericarditis, pneumonitis, hematologic abnormalities), renal or hepatic failure.
How Supplied:
Supps—30, 42
