• Colorectal disorders

Colorectal disorders:

Indications for CANASA:

Mild-to-moderately active ulcerative proctitis.

Adult:

Retain supp in rectum for at least 1–3hrs. 1g once daily at bedtime. Treat for 3–6 weeks.

Children:

Not established.

Warnings/Precautions:

Sulfasalazine or aspirin allergy. Renal or hepatic impairment. Evaluate renal function before starting and periodically during therapy. Monitor for acute intolerance syndrome; discontinue if suspected. May stain clothes. Elderly. Pregnancy. Nursing mothers.

Pharmacologic Class:

Aminosalicylate.

Interactions:

Concomitant nephrotoxic agents (eg, NSAIDs) may increase risk of renal effects; monitor. Concomitant azathioprine or 6-mercaptopurine may increase risk of blood disorders; if unavoidable, monitor CBCs and platelets. May interfere with measurements by liquid chromatography of urinary normetanephrine; consider other alternative assay.

Adverse Reactions:

Dizziness, rectal pain, fever, rash, acne, colitis, headache, flatulence, abdominal pain, diarrhea, nausea; mesalamine-induced acute intolerance syndrome, hypersensitivity reactions (including myocarditis, pericarditis, pneumonitis, hematologic abnormalities), renal or hepatic failure.

How Supplied:

Supps—30, 42

Pricing for CANASA

1000mg suppository (Qty: 30)
Appx. price $343
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