Vitamins, minerals, supplements:
Indications for: ASCOR
Short term (up to 1 week) treatment of scurvy in patients aged ≥5 months for whom oral administration is not possible, insufficient or contraindicated.
Limitations of Use:
Not for Vit.C deficiency that is not associated with signs and symptoms of scurvy.
Adults and Children:
<5mos: not established. See full labeling. Prior to administration, Ascor must be diluted. Give as slow IV infusion. 5–<12mos: 50mg once daily at infusion rate of 1.3mg/min; 1–<11yrs: 100mg once daily at infusion rate of 3.3mg/min; ≥11yrs: 200mg once daily at infusion rate of 33mg/min. The max duration of daily treatment is for 7 days; if no improvement after 1 week, may retreat until symptoms resolve. Repeat dosing in patients <11yrs: not recommended.
Not for prolonged administration. Risk of oxalate nephropathy with prolonged and high doses. Increased risk of oxalate nephropathy in those with renal disease (including renal impairment, history of oxalate kidney stones, on dialysis, diabetic nephropathy, renal transplant recipients, elderly, patients <2yrs of age); monitor renal function. Discontinue therapy if oxalate nephropathy occurs; treat if suspected. Increased risk of severe hemolysis in those with glucose-6-phosphate dehydrogenase deficiency; monitor hemoglobin, CBCs, and use a reduced Ascor dose. Discontinue therapy if hemolysis is suspected; treat as needed. Minimize exposing vial to light. Pregnant, nursing mothers, or patients with glucose-6-dehydrogenase deficiency: do not exceed the Recommended Dietary Allowance (RDA) or daily Adequate Intake (AI) level for their age and condition.
May antagonize antibiotics (eg, erythromycin, kanamycin, streptomycin, doxycycline, lincomycin); if antibiotic efficacy is suspected to be decreased, discontinue Ascor. May acidify urine and increase excretion of certain drugs (eg, amphetamine, fluphenazine); if amphetamine efficacy decreases, discontinue Ascor. Monitor with warfarin. May lead to false (negative) results with lab tests based on oxidation-reduction reactions (eg, glucose, nitrite and bilirubin levels, leukocyte count); if possible, delay testing until 24hrs after Ascor infusion.
Local site reactions (pain, swelling).
Generic Drug Availability:
Pharmacy bulk package (50mL)—1, 25