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DIFLUCAN 150mg
Vaginal infections
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Drug Name:

DIFLUCAN 150mg Rx

Generic Name and Formulations:
Fluconazole 150mg; tabs.

Company:
Pfizer Inc.

Therapeutic Use:

Indications for DIFLUCAN 150mg:

Vaginal candidiasis.

Adult:

150mg orally once.

Children:

Not recommended.

Contraindications:

Concomitant terfenadine at multiple doses of fluconazole ≥400mg. Concomitant drugs known to prolong the QT interval and metabolized by CYP3A4 (eg, cisapride, astemizole, erythromycin, pimozide, quinidine).

Warnings/Precautions:

Risk of serious hepatotoxicity; monitor liver function during therapy and for signs/symptoms of hepatic injury; discontinue if occurs. Proarrhythmic conditions. Monitor closely for skin rashes; discontinue if lesions progress. Renal or hepatic impairment. Elderly. Pregnancy (Cat.C). Nursing mothers.

Pharmacological Class:

Azole antifungal.

Interactions:

See Contraindications. Avoid concomitant voriconazole; if needed, monitor closely esp. when given within 24hrs after fluconazole. Caution with amiodarone (esp. with high-dose fluconazole), other drugs metabolized by CYP2C9 and CYP3A4 with a narrow therapeutic window. Potentiates warfarin, oral hypoglycemics, oral midazolam, triazolam, tofacitinib, alfentanil, amitriptyline, nortriptyline, saquinavir, tacrolimus, sirolimus, carbamazepine, methadone, NSAIDs, zidovudine; adjust dose as necessary. May increase levels of phenytoin, theophylline, halofantrine, rifabutin, vinca alkaloids, cyclosporine, fentanyl, calcium channel blockers, losartan; monitor. Concomitant celecoxib: reduce celecoxib dose by half. Increased risk of myopathy/rhabdomyolysis with concomitant HMG-CoA reductase inhibitors; closely monitor. May be potentiated by diuretics. May be antagonized by oral cimetidine, rifampin. Concomitant prednisone: monitor for adrenal cortex insufficiency when fluconazole stopped. CNS effects with Vitamin A. Oral contraceptives: see full labeling. Avoid other hepatotoxic drugs.

Adverse Reactions:

Nausea, headache, rash, vomiting, abdominal pain, diarrhea, dizziness; hepatotoxicity; rare: anaphylaxis, exfoliative dermatitis, QT prolongation, Torsade de pointes.

How Supplied:

Tabs—1

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