Obesity may predispose breast tissue structure to cancer

Share this content:
Obesity May Fuel Breast CA Via Change in Breast Tissue Structure
Obesity May Fuel Breast CA Via Change in Breast Tissue Structure

(HealthDay News) -- Obesity enhances local myofibroblast content and stiffness-promoting extracellular matrix (ECM) components in mammary adipose tissue, according to an experimental study published in the Aug. 19 issue of Science Translational Medicine.

Bo Ri Seo, from Cornell University in Ithaca, N.Y., and colleagues examined whether obesity and ECM density are functionally linked in breast cancer. The authors used mouse models to examine whether obesity enhances local myofibroblast content in mammary adipose tissue and whether these changes enhance interstitial ECM stiffness.

The researchers found that myofibroblasts and stiffness-promoting ECM components were enriched in mammary fat of both diet- and genetically-induced mouse models of obesity. These alterations correlated with varied adipose stromal cell (ASC) characteristics; compared with ASCs from lean control mice, ASCs isolated from obese mice contained more myofibroblasts and deposited denser and stiffer EMCs. Mechanosignaling was stimulated by decellularized matrices from obese ASCs, affecting the malignant potential of breast cancer cells. The findings were supported by analysis of specimens from obese breast cancer patients, and the observation that in a mouse model, caloric restriction reduced myofibroblast content in mammary fat.

"Collectively, these findings suggest that obesity-induced interstitial fibrosis promotes breast tumorigenesis by altering mammary ECM mechanics with important potential implications for anticancer therapies," the authors write.

Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

You must be a registered member of ONA to post a comment.

Sign Up for Free e-newsletters

Regimen and Drug Listings


Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Genitourinary Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Rare Cancers Regimens
Skin Cancer Regimens Drugs