Increased risk of colorectal cancer with type 2 diabetes

This article originally appeared here.
Share this content:
Moderately Increased Risk of Colorectal Cancer in T2DM
Moderately Increased Risk of Colorectal Cancer in T2DM

(HealthDay News) -- The risk of colorectal cancer is moderately increased in patients with type 2 diabetes, according to research published online Dec. 31 in Diabetes Care.

Paul J.H.L. Peeters, of the Utrecht University in the Netherlands, and colleagues conducted an observational population-based cohort study in which 300,039 patients, aged 18 years or older, with at least one prescription for an antidiabetic drug, were matched with a comparison cohort of individuals without diabetes. The risk of colorectal cancer associated with type 2 diabetes was assessed.

The researchers found, at a median follow-up of 4.5 years, 2,759 cases of colorectal cancer in patients with diabetes. Type 2 diabetes was associated with increased risk of colorectal cancer (hazard ratio [HR], 1.26; 95 percent confidence interval [CI], 1.18 to 1.33). No association was found between risk of colorectal cancer and treatment stages for diabetes. Risk of colorectal cancer was significantly higher in patients with documented duration of obesity of four to eight years (HR, 1.19; 95 percent CI, 1.06 to 1.34) and longer than eight years (HR, 1.28; 95 percent CI, 1.11 to 1.49).

"In summary, we observed a moderate, yet (1.3-fold) significantly increased, risk of colorectal cancer in patients treated for type 2 diabetes," the authors write.

One author conducts research coordinated by an institution that receives funding partly from pharmaceutical companies.

Full Text (subscription or payment may be required)

You must be a registered member of ONA to post a comment.

Sign Up for Free e-newsletters

Regimen and Drug Listings


Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Genitourinary Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Rare Cancers Regimens
Skin Cancer Regimens Drugs