CT colonography accurate for 10 mm adenomas

This article originally appeared here.
Share this content:
CT Colonography Accurate for 10 mm Adenomas
CT Colonography Accurate for 10 mm Adenomas

(HealthDay News) -- For patients at average-to-moderate risk of colon cancer, computed tomographic colonography (CTC) accurately detects adenomas 10 mm or larger, but not smaller lesions, according to a study published in the May 15 issue of the Annals of Internal Medicine.

Michael E. Zalis, M.D., from Massachusetts General Hospital in Boston, and colleagues conducted a prospective test comparison of laxative-free CTC, which involves electronic cleansing and computer-aided detection, and optical colonoscopy (OC) for detection of adenomas in 605 adults aged 50 to 85 years.

The researchers found that, for adenomas 10 mm or larger, the per-patient sensitivity and specificity of CTC was 0.91 and 0.85, respectively. The corresponding values for OC were 0.95 and 0.89. For adenomas at the threshold of 8 mm or larger, the corresponding values were 0.70 and 0.86 for CTC and 0.88 and 0.91 for OC. For adenomas 6 mm and larger, the sensitivity and specificity were 0.59 and 0.88, respectively, for CTC, and 0.76 and 0.94, respectively, for OC. Patients reported greater comfort and less difficulty of examination preparation for CTC than for OC.

"Computed tomographic colonography was accurate in detecting adenomas 10 mm or larger but less so for smaller lesions," the authors write. "Patient experience was better with laxative-free CTC. These results suggest a possible role for laxative-free CTC as an alternate screening method."

The study was supported by grants from GE Healthcare. Several authors are co-inventors of electronic cleansing and computer-aided detection software patents.

Full Text (subscription or payment may be required)

You must be a registered member of ONA to post a comment.

Sign Up for Free e-newsletters

Regimen and Drug Listings


Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Genitourinary Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Rare Cancers Regimens
Skin Cancer Regimens Drugs