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Metronidazole, Vancomycin Recommended for <i>C Difficile</i> in Pediatric Oncology, HSCT

Metronidazole, Vancomycin Recommended for C Difficile in Pediatric Oncology, HSCT

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An international multidisciplinary panel of experts in pediatric oncology and infectious diseases convened to develop recommendations for the prevention and treatment of C difficile infection in pediatric patients with cancer or who are undergoing HSCT.

CDC: HPV Vaccination Rates on the Rise Among Adolescents

CDC: HPV Vaccination Rates on the Rise Among Adolescents

Proportion of teens up to date with HPV vaccines also increasing, researchers found.

FDA Grants Approval to Novel Treatment for Hairy Cell Leukemia

FDA Grants Approval to Novel Treatment for Hairy Cell Leukemia

Lumoxiti, a CD22-directed cytotoxin, has been approved for adult patients who have had at least two prior therapies for the disease.

Failure Rates for HPV Vaccine Higher in HIV-Positive Women, Girls

Failure Rates for HPV Vaccine Higher in HIV-Positive Women, Girls

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Canadian investigators conducted a national observational study in which women and girls living with HIV underwent HPV vaccination.

American Association for Cancer Research Releases Its 2018 Annual Report

American Association for Cancer Research Releases Its 2018 Annual Report

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In its 2018 annual report, the AACR highlights the advances, challenges, and needs of federally funded research on the prevention, detection, diagnosis, and treatment of cancer.

Triplet Regimen Found Most Effective for Relapsed/Refractory Multiple Myeloma

Triplet Regimen Found Most Effective for Relapsed/Refractory Multiple Myeloma

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An updated network meta-analysis found that a triplet regimen consisting of lenalidomide and dexamethasone plus an immunotherapeutic agent had better efficacy in terms of NRR, TTP, PFS, and OS than other regimens.

Use of Anti-inflammatory Analgesics Has a Positive Effect on Survival Outcomes in Ovarian Cancer

Use of Anti-inflammatory Analgesics Has a Positive Effect on Survival Outcomes in Ovarian Cancer

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The use of anti-inflammatory analgesics, such as aspirin, may extend survival for patients with ovarian cancer.

Pulmonary Toxicity Increased in Pediatric Hodgkin Lymphoma Treated With Brentuximab Vedotin

Pulmonary Toxicity Increased in Pediatric Hodgkin Lymphoma Treated With Brentuximab Vedotin

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A retrospective study evaluated the efficacy vs pulmonary toxicity of brentuximab vedotin for relapsed or refractory Hodgkin lymphoma in pediatric patients.

Social Support Is Biggest Determinant of Life Satisfaction for Adolescents With Cancer

Social Support Is Biggest Determinant of Life Satisfaction for Adolescents With Cancer

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Using the Questions on Life Satisfaction (FLZ-M) questionnaire, researchers determined the extent of life satisfaction across 10 subdomains reported by adolescents and young adults with cancer.

Rituximab Maintenance Improved Long-Term Survival in Elderly With Follicular Lymphoma

Rituximab Maintenance Improved Long-Term Survival in Elderly With Follicular Lymphoma

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A retrospective analysis of outcomes demonstrated the influence of rituximab maintenance after R-CHOP or R-CVP for follicular lymphoma in elderly patients.

Insurance Status Influences Overall Survival in Follicular Lymphoma

Insurance Status Influences Overall Survival in Follicular Lymphoma

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Outcomes data demonstrated the impact of socioeconomic status and insurance coverage on outcomes for patients with follicular lymphoma by age (younger than 65 and 65 and older).

Fostamatinib Appears Effective for Immune Thrombocytopenia

Fostamatinib Appears Effective for Immune Thrombocytopenia

Researchers found that stable responses occurred in 18 percent of patients on fostamatinib, versus 2 percent on placebo.

Experiencing Parental Cancer As Child Can Have Lasting Impact

Experiencing Parental Cancer As Child Can Have Lasting Impact

An increased risk of low educational attainment and attenuation in income at age 30 years has been observed in those that have experienced parental cancer.

Late Lower Cranial Neuropathy Worsens Symptom Burden in Oropharyngeal Cancer Survivors

Late Lower Cranial Neuropathy Worsens Symptom Burden in Oropharyngeal Cancer Survivors

Researchers conducted a cross-sectional study to determine the incidence and effect of late lower cranial neuropathies on survivors of oropharyngeal cancers.

Too Much Physical Activity During Therapy for Pediatric ALL Decreases Cognitive Function

Too Much Physical Activity During Therapy for Pediatric ALL Decreases Cognitive Function

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Using a longitudinal parallel-process model, researchers evaluated the impact of physical activity on symptoms, physical activity, and cognitive function in children with ALL undergoing chemotherapy.

Poor, Non-English Speaking Cancer Patients Need Support

Poor, Non-English Speaking Cancer Patients Need Support

Non-English speaking and uninsured patients with cancer may require additional support systems, such as referral to socioeconomic support, for best care.

Preventative Medications Unnecessarily Prescribed to EOL Patients With Lung Cancer

Preventative Medications Unnecessarily Prescribed to EOL Patients With Lung Cancer

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In a retrospective study conducted in the United States and the United Kingdom, researchers evaluated the prescribing of preventative medications in patients with lung cancer discharged from hospital at the end of life.

Outcomes in Bladder Cancer Tend to Be Poorer With Higher Body Mass Index

Outcomes in Bladder Cancer Tend to Be Poorer With Higher Body Mass Index

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An increased body mass index (BMI) may negatively affect disease progression in patients with T1G3 non-muscle-invasive bladder cancer, according to study data.

RiBVD Effective in the First-Line Setting for Mantle Cell Lymphoma

RiBVD Effective in the First-Line Setting for Mantle Cell Lymphoma

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Researchers sought to determine if the newly formed regimen RiBVD was effective and tolerable in patients older than 65 with mantle cell lymphoma.

Lurbinectedin a Possible Option for Acute Myeloid Leukemia, Myelodysplastic Syndrome

Lurbinectedin a Possible Option for Acute Myeloid Leukemia, Myelodysplastic Syndrome

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A phase 1 dose-finding study determined which of 2 lurbinectedin dosing schedules had greater effectiveness and fewer AEs in patients with relapsed/refractory MDS or AML.

Computer-Aided Colonoscopy Reliably Identifies Small Polyps

Computer-Aided Colonoscopy Reliably Identifies Small Polyps

Researchers evaluated the performance of real-time CAD with endocytoscopes among 791 consecutive patients undergoing colonoscopy.

Lenalidomide Plus R-CHOP Effective in High-Burden Follicular Lymphoma

Lenalidomide Plus R-CHOP Effective in High-Burden Follicular Lymphoma

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A phase 2 study was conducted to determine the effectiveness of adding lenalidomide to R-CHOP as a first-line treatment for high-burden follicular lymphoma.

High-Quality Diet Associated With Lower Mortality in Cancer Survivors

High-Quality Diet Associated With Lower Mortality in Cancer Survivors

Compared with a poor-quality diet (lowest-quartile HEI score), a high-quality diet correlated with a reduced risk of overall and cancer-specific mortality.

Additional Mammography Between Regular Screenings May Improve Breast Cancer Detection

Additional Mammography Between Regular Screenings May Improve Breast Cancer Detection

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The MSP in Germany is designed to detect breast cancer during annually scheduled screenings and between the last negative and following screening among survivors.

Expressive Writing May Improve Psychiatric Symptoms After Cancer Diagnosis

Expressive Writing May Improve Psychiatric Symptoms After Cancer Diagnosis

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Pennebaker's expressive writing intervention was developed to allow patients to express their worries and pains.

Clarithromycin Plus Bortezomib May Be Ineffective, Toxic in Multiple Myeloma

Clarithromycin Plus Bortezomib May Be Ineffective, Toxic in Multiple Myeloma

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Researchers found that clarithromycin plus bortezomib does not confer any additional efficacy and is a toxic in patients with multiple myeloma.

SD-101 May Enhance the Effectiveness of Immunotherapy in Melanoma

SD-101 May Enhance the Effectiveness of Immunotherapy in Melanoma

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In this phase 1b study, researchers evaluated the efficacy of immunotherapy with pembrolizumab to treat advanced melanoma.

Ibrutinib Compared With Chemotherapy in Treatment-Naive CLL

Ibrutinib Compared With Chemotherapy in Treatment-Naive CLL

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Ibrutinib monotherapy may reduce the need for chemotherapy for some treatment-naive patients with chronic CLL, research indicates.

OS Better With Ovarian Suppression Plus Tamoxifen or Exemestane for Premenopausal Breast Cancer

OS Better With Ovarian Suppression Plus Tamoxifen or Exemestane for Premenopausal Breast Cancer

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Tamoxifen or exemestane plus ovarian suppression more effectively increases survival than tamoxifen alone for premenopausal women with breast cancer.

A Novel Formulation of Melphalan May Not Prevent Complications Post-ASCT in Multiple Myeloma

A Novel Formulation of Melphalan May Not Prevent Complications Post-ASCT in Multiple Myeloma

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High-dose melphalan is a frequently before ASCT in MM, but is associated with high rates of adverse events.

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