Researchers report on the effectiveness results of the Supportive Care of Oncology Patients (SCOOPs) Program were presented at the 2018 ASCO Quality Care Symposium.
Results of a study in which more than 100 patients with metastatic colorectal cancer completed EORTC-QLQ-C30 suggests an association between assessment of cumulative drug toxicities and predictions of quality of life for patients undergoing first-line chemotherapy for the disease.
Tailoring fecal immunochemical tests positivity thresholds by age and sex may help to optimize colorectal cancer screeningSeptember 24, 2018
1. Cancer detection among participants was higher with lower positivity thresholds. 2. Sensitivity with conventional fecal immunochemical tests (FIT) thresholds decreased with increasing age and female gender. Evidence Rating Level: 2 (Good) Study Rundown: FIT directly measure human hemoglobin concentrations in the stool commonly and are commonly used for colorectal cancer screening. Despite demographic variations in 
1. In this phase 3 randomized controlled trial, fruquintinib increased median overall survival and progression-free survival compared to placebo in patients with colorectal cancer who had already undergone second line or subsequent treatment. 2. Fruquintinib was associated with an increase rate of adverse effects. Evidence Rating Level: 1 (Excellent) Study Rundown: Biological agents that target 
CDC investigators found that from 2000 to 2015, screening for breast, cervical, and prostate cancers decreased significantly.
Weight loss associated with bariatric surgery could reduce risk of hormone-related cancers, but an increased risk for colorectal cancer was seen in patients who underwent gastric bypass.
A retrospective review of data from the National Cancer Data Base demonstrated that trends in rectal cancer may follow a pattern similar to that of colon cancer.
Novel Quinazoline-based Sulfonamide Derivative (3D) Induces Apoptosis in Colorectal Cancer by Inhibiting JAK2-STAT3 PathwayJuly 13, 2018
[OncoTargets and Therapy] Researchers investigated the anticancer effects of a novel sulfonamide derivative in the treatment of colorectal cancer.
Study results presented at 2018 ASCO Annual Meeting demonstrated effectiveness of ado-trastuzumab emtansine in non-breast non-gastric HER2-amplified cancers.
1. Patients with advanced adenomas identified on flex sigmoidoscopy had a significantly increased risk of death from colorectal cancer (CRC) compared to those with no adenomas. 2. There was no difference in cumulative CRC incidence in patients with nonadvanced adenomas as compared to those with no adenomas. Evidence Rating: 1 (Excellent) Study Rundown: Colorectal cancer 
[Gastrointestinal Cancer: Targets and Therapy] This review presents the most up-to-date molecular, clinical, and therapeutic data, including an overview of a current phase 3 study assessing the efficacy of simultaneous BRAF, EGFR, and MEK inhibition among patients with BRAFV600E-mutant CRC.
Researchers evaluated survival in patients with colon cancer, according to the type of insurance the patients held.
A review of the literature on follow-up after positive screening results led researchers to a consensus opinion on timing of diagnostic tests for 4 cancers: breast, cervical, colorectal, and lung.
A cross-sectional analysis evaluated the impact of hope and optimism on different facets of psychological distress among patients with advanced melanoma, colorectal, lung, or gastrointestinal cancers.
1. Sigmoidoscopy was associated with a reduction in the prevalence of colon cancer mortality in men. 2. Sigmoidoscopy did not appear to have a significant protective effect for women with respect to decreasing the rates of colorectal cancer. Evidence Rating Level: 1 (Excellent) Study Rundown: Colorectal cancer (CRC) is one of the most common cancers 
Researchers conducted a case-control study to determine whether colonoscopy is associated with decreased CRC mortality in veterans and whether its effect differs by anatomical location of CRC.
A prospective study assessing the outcomes of a cohort of participants in the CALGB 89803 study determined the effect of following the American Cancer Society guidelines on survival for persons with colon cancer.
BEACON CRC Safety Lead-in Study suggests safety and efficacy of triplet combination therapy for treatment of metastatic colorectal cancerApril 13, 2018
1. BEACON CRC is a multicenter, randomized, phase 3 clinical trial evaluating the triplet combination of binimetinib (BINI, a MEK inhibitor) + encorafenib (ENCO, a BRAF inhibitor) + cetuximab (CETUX, an EGFR antibody) for the treatment of metastatic colorectal cancer. 2. Preliminary analysis of the Safety Lead-in Study for the BEACON CRC reveals that the 
1. Enrollment in Medicare Shared Savings Program (MSSP) Accountable Care Organizations (ACO) was associated with a decrease in breast cancer screening, increase in colorectal cancer screening, and decreased prostate cancer screening, reflecting more appropriate utilization of screening tests. 2. Changes in breast and colon cancer screening were strongly influenced by participant age. Evidence Rating Level: 
Results of the phase 3 AXEPT study were used to determine the noninferiority of a modified XELIRI regimen vs a FOLFIRI regimen in terms of overall survival among patients with metastatic colorectal cancer (mCRC).
Fifty-three percent of intervention participants used app to self-order a colorectal screening test.
1. Colonoscopy in veterans was associated with reduced mortality from both left and right-sided colorectal cancer. 2. Mortality was reduced by 61% in patients screened by colonoscopy. Evidence Rating Level: 2 (Good) Study Rundown: Colorectal cancer (CRC) screening serves as a critical element of CRC prevention and management. To date, colonoscopy remains the gold standard 
1. Digital health intervention resulted in significantly higher colon cancer screening rates among participants. 2. No statistically significant relationship was observed between the digital health intervention and health literacy, income, or race and ethnicity. Evidence Rating Level: 1 (Excellent) Study Rundown: Colorectal cancer (CRC) is one of the leading causes of cancer in both men 
Investigators conducted a prospective observational study involving patients with stage III colon cancer to examine the correlation of nut intake with cancer mortality.
Analysis revealed factors that contribute to reduced dietary intake among hospitalized patients with colorectal cancer.
Investigators examined correlations between an empirical dietary inflammatory pattern (EDIP) score and colorectal cancer risk.
Safety and efficacy of atezolizumab with cobimetinib for heavily pretreated metastatic CRC was demonstrated in a phase 1b study that was presented at the 2018 Gastrointestinal Cancers Symposium.
Study results presented at the 2018 Gastrointestinal Cancers Symposium demonstrated the sensitivity and specificity of the CMx biomimetic platform, a novel approach to detecting CRC and precancerous lesions that could improve screening rates.
No additional risk of colorectal cancer was noted among women treated with aromatase inhibitors (AIs) following a median follow-up of 2.4 and 2.9 years.
New research on the benefits of high-fiber diets for CRC survivors took its findings one step further and identified the type of fiber consumed and which provided better benefits.
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