Overall, patient survival was not associated with surgical technique.
Researchers present results of an interim analysis of a study on the prevalence of advanced colorectal neoplasia among survivors of Hodgkin lymphoma.
A retrospective review identified a subset of patients with squamous cell carcinoma of the anal canal with distant metastases who respond to extended-field chemoradiation.
Researchers reviewed cancer incidence in patients with Diamond-Blackfan anemia.
A prospective analysis of diets before and after diagnosis revealed dietary habits among patients with colorectal cancer that may help prolong survival.
Researchers report on the effectiveness results of the Supportive Care of Oncology Patients (SCOOPs) Program were presented at the 2018 ASCO Quality Care Symposium.
Results of a study in which more than 100 patients with metastatic colorectal cancer completed EORTC-QLQ-C30 suggests an association between assessment of cumulative drug toxicities and predictions of quality of life for patients undergoing first-line chemotherapy for the disease.
Researchers evaluated the performance of real-time CAD with endocytoscopes among 791 consecutive patients undergoing colonoscopy.
CDC investigators found that from 2000 to 2015, screening for breast, cervical, and prostate cancers decreased significantly.
Weight loss associated with bariatric surgery could reduce risk of hormone-related cancers, but an increased risk for colorectal cancer was seen in patients who underwent gastric bypass.
A retrospective review of data from the National Cancer Data Base demonstrated that trends in rectal cancer may follow a pattern similar to that of colon cancer.
Novel Quinazoline-based Sulfonamide Derivative (3D) Induces Apoptosis in Colorectal Cancer by Inhibiting JAK2-STAT3 Pathway
[OncoTargets and Therapy] Researchers investigated the anticancer effects of a novel sulfonamide derivative in the treatment of colorectal cancer.
Colorectal cancer treatment regimen chart.
Study results presented at 2018 ASCO Annual Meeting demonstrated effectiveness of ado-trastuzumab emtansine in non-breast non-gastric HER2-amplified cancers.
[Gastrointestinal Cancer: Targets and Therapy] This review presents the most up-to-date molecular, clinical, and therapeutic data, including an overview of a current phase 3 study assessing the efficacy of simultaneous BRAF, EGFR, and MEK inhibition among patients with BRAFV600E-mutant CRC.
Researchers evaluated survival in patients with colon cancer, according to the type of insurance the patients held.
A review of the literature on follow-up after positive screening results led researchers to a consensus opinion on timing of diagnostic tests for 4 cancers: breast, cervical, colorectal, and lung.
A cross-sectional analysis evaluated the impact of hope and optimism on different facets of psychological distress among patients with advanced melanoma, colorectal, lung, or gastrointestinal cancers.
Researchers conducted a case-control study to determine whether colonoscopy is associated with decreased CRC mortality in veterans and whether its effect differs by anatomical location of CRC.
A prospective study assessing the outcomes of a cohort of participants in the CALGB 89803 study determined the effect of following the American Cancer Society guidelines on survival for persons with colon cancer.
Results of the phase 3 AXEPT study were used to determine the noninferiority of a modified XELIRI regimen vs a FOLFIRI regimen in terms of overall survival among patients with metastatic colorectal cancer (mCRC).
Fifty-three percent of intervention participants used app to self-order a colorectal screening test.
Investigators conducted a prospective observational study involving patients with stage III colon cancer to examine the correlation of nut intake with cancer mortality.
Study results presented at the NACNS 2018 Annual Conference demonstrate the efficacy of SSI bundle element compliance and multidisciplinary clinical collaboration in reducing colon surgical site infections.
Analysis revealed factors that contribute to reduced dietary intake among hospitalized patients with colorectal cancer.
Investigators examined correlations between an empirical dietary inflammatory pattern (EDIP) score and colorectal cancer risk.
Safety and efficacy of atezolizumab with cobimetinib for heavily pretreated metastatic CRC was demonstrated in a phase 1b study that was presented at the 2018 Gastrointestinal Cancers Symposium.
Study results presented at the 2018 Gastrointestinal Cancers Symposium demonstrated the sensitivity and specificity of the CMx biomimetic platform, a novel approach to detecting CRC and precancerous lesions that could improve screening rates.
No additional risk of colorectal cancer was noted among women treated with aromatase inhibitors (AIs) following a median follow-up of 2.4 and 2.9 years.
New research on the benefits of high-fiber diets for CRC survivors took its findings one step further and identified the type of fiber consumed and which provided better benefits.
Increasing fiber consumption after diagnosis may lower risk of all-cause, CRC-specific mortality.
A small study of 50 patients undergoing FOLFOX for CRC determined if adding aprepitant to standard antiemetic prophylactic treatment would improve CINV in this patient population.
An analysis of 23 studies focused on interventions with the potential to improve follow-up colonoscopy completion rates found that navigation programs are more effective than other interventions studied.
Investigators sought to determine clinical and cost effectiveness of additional colonoscopy screening in patients undergoing FIT screening for colorectal cancer.
Bevacizumab-awwb is a recombinant IgG1 monoclonal antibody that works by binding to vascular endothelial growth factor (VEGF) and inhibits angiogenesis.
Sarcopenia is significantly associated with dose reductions but not with dose-limiting toxicities at initiation of CAPOX-B reinduction therapy in patients with mCRC, researchers reported at ESMO 2017 Congress.
A newly developed patient education resource helps nurses educate patients with colorectal cancer about biomarker testing and counsel them on the significance of the results.
Researchers examined the impact of exercise and low body fat mass on recurrence of colorectal polyps among survivors of colorectal cancer.
Among adults aged 20 to 54 years, increase in CRC mortality only seen in whites aged 30 to 54 years.
This study investigated the impact of exercise (1 hour/week) and low body fat mass on recurrence of colorectal polyp recurrence among survivors of colorectal cancer.
Researchers investigated whether a financial reward could help drive colorectal cancer participation.
Overweight teens in Israel had about a 53 percent higher risk for colon cancer as adults, researchers found.
Skin Toxicity Evaluation in Patients Treated With Cetuximab for Metastatic Colorectal Cancer: A New Tool for More Accurate Comprehension of Quality of Life Impacts
This research aims to assess the correlation between quality of life (QoL) and severity of dermatological toxicity in patients with metastatic colorectal cancer.
The United States Multi-Society Task Force (MSTF) on Colorectal Cancer Screening updated its recommendations, confirming that screening in people at average risk should begin at age 50 years. The update also includes a ranking of current screening modalities.
Regular use of NSAIDs after diagnosis of colorectal cancer correlated with improved survival in survivors with KRAS wild-type tumors.
The AR inhibitor fidarestat is effective as adjuvant therapy to enhance doxorubicin sensitivity of colorectal cancer cells and to reduce cardiotoxicity associated with the drug.
By identifying incidence, prevalence, and risk factors for colorectal and pancreatic cancer in our communities, nurse navigators can develop screening and prevention programs to better serve these populations.
Patient and Physician Preferences for Anticancer Drugs for the Treatment of Metastatic Colorectal Cancer: A Discrete-choice Experiment
[Cancer Management and Research] This research examines preferences and risk tolerance among patients and oncologists in the USA for anticancer drugs to treat metastatic colorectal cancer (mCRC).
Study compared FOLFOXIRI/bevacizumab and FOLFOX/bevacizumab in patients with metastatic colorectal cancer.
'Conquer Fear' decreased fear among survivors of breast and colorectal cancer and melanoma compared with relaxation techniques.
Patients with stage III colon cancer who follow the ACS guidelines for a healthy lifestyle after adjuvant chemotherapy had longer disease-free survival and overall survival.
Consumption of tree nuts is associated with significantly improved disease-free survival (DFS) and overall survival (OS) in survivors of stage III colon cancer who consume 2 or more servings per week.
Tumor mutation load (TML) may be a factor in higher rates of colorectal cancer among younger persons as TML is 3 times higher in younger patients with colorectal cancer.
Comprehensive After Surgery Recovery Program Reduces Complication Rates and Improves Surgical Outcomes
Postoperative program improves complication rates, opioid prescribing, and hospital mortality and increases home discharge rates after colorectal or hip fracture surgery.
Scientists at Texas A&M University traced how eating a daily dose of prunes affects colon biochemistry, and the role this diet may play in cancer prevention.
Risk for Disease, Advanced Stage at Diagnosis Higher With Delayed Colonoscopy After Positive FIT Results
Waiting 10 months or longer before follow-up colonoscopy after a positive FIT result is associated with higher risk of disease as well as advanced stage at diagnosis.
Consuming the equivalent of 5 prunes per day may provide a unique combination of biologically active compounds that can reduce the risk of colon cancer.
Including beans and whole grains such as rice in the diet is associated with a reduced burden of CRC in survivors.
Patients' confidence with colorectal cancer screening procedures is predictive of their likelihood to schedule and follow through with screening.
Although median survival is longer for Hispanic and black patients compared with white patients, health-related QoL is poor for minority patients.
Transportation issues, lack of awareness, other barriers may be to blame for diminished colorectal screening rates.
Predictive risk model shows that lifestyle choices have a greater influence on risk for colorectal cancer than does genetic factors.
Incidence of colon and rectal cancers are increasing sharply in people younger than 50 years, the recommended age for initiating screening.
ACS colorectal cancer statistics show an overall decrease in incidence due to increases in screening rates; however, age-related incidence is trending up in younger persons, down in older persons.
Outcomes improved with short-course radiation and delay to surgery of 4 to 8 weeks.
Women with poor metabolic health have a greater risk of colorectal cancer than those with increased weight.
Chemotherapy may be overused among young and middle-aged adults with colon cancer, with the addition of adjuvant chemotherapy not resulting in a matched survival benefit.
Geographic location was seen to affect disease stage at diagnosis among people with colorectal cancer who live in ethnically or racially segregated communities.
An assessment of the use of mammography and colonoscopy among fee-for-service Medicare beneficiaries before and after the Affordable Care Act demonstrates the impact of out-of-pocket costs in this population.
Moderate but not vigorous activity proved beneficial for patients with metastatic colorectal cancer.
MABp1 (Xilonix) is an interleukin 1α-targeting antibody associated with antitumor activity and relief of debilitating symptoms in patients with advanced colorectal cancer. In this ongoing phase 3 clinical trial, its impact on other debilitating symptoms in this population was evaluated.
Omega-3 Polyunsaturated Fatty Acids in the Prevention of Postoperative Complications in Colorectal Cancer: A Meta-analysis
[OncoTargets and Therapy] This research evaluates the clinical efficacy of omega-3 PUFAs in the prevention of postoperative complications in colorectal cancer patients.
Researchers compared the effectiveness of NSAIDs, aspirin, and several nutritional supplements for the prevention of recurrent adenomatous neoplasia after colon polyp removal.
Drug-drug interaction between capecitabine and common heartburn medications has a negative effect on progression-free survival and overall survival in patients with GI cancer.
Given the frequency of gene mutations in patients with early-onset CRC, genetic counseling and testing could be considered for this population.
Study results demonstrate effectiveness of 4 weeks of prehabilitation on the physical fitness of older patients undergoing surgery for colorectal cancer.
Survey data from patients receiving care at Boston Medical Center who were navigated for colonoscopy screening illustrates how patients value the services of oncology patient navigators.
A possible association between moderate to heavy alcohol consumption has been shown in previous studies. In this study, investigators examined the relationship between alcohol consumption and colorectal cancer survival remains unclear.
Researchers observed a significant disparity in colon cancer mortality related to origin location, independent of confounding variables.
FIT has several advantages over gFOBT, but practical concerns should be considered
In this study, the impact of advancements in surgical technique and systemic therapy for stage II and III rectal cancers was assessed via a comparison of outcomes after neoadjuvant chemoradiotherapy followed by definitive resection with those for neoadjuvant multiagent chemotherapy without radiation therapy.
Adopting healthy lifestyle can cut 25-year risk for the disease from 29 to 13 percent.
Novel preparation formulation is as effective and safe as current colon prep for colonoscopy. Plus, study participants gave the prep experience a high satisfaction rating.
The model for the Affordable Care Act, the 2006 Massachusetts health care reform, was associated with increased resection rates and a reduced risk for emergency resection in patients with colorectal cancer.
A new colorectal cancer (CRC) screening test that can be done in the privacy of patients' homes, at their convenience, and with no prep needed may help patients overcome their reticence.
The combination of adjuvant bevacizumab and capecitabine failed to improve disease-free survival compared with capecitabine alone in patients with mCRC who had undergone potentially curative surgery.
Adding rolapitant to a 5-HT3 receptor antagonist and dexamethasone significantly improved the prevention of CINV in patients with GI and CRC cancers receiving highly or moderately emetogenic chemotherapy.
Patients who have little to no understanding of the health system, multiple comorbid conditions, do not receive a written treatment plan, or do not have contact with a cancer care coordinator or specialist nurse have significantly poorer care coordination.
Lifestyle and dietary measures for preventing colorectal cancer are extensively studied; however, in this study, researchers looked at a dietary measure that improved survival for patients after diagnosis.
Danish researchers identified a microRNA shown to predict whether a patient with colorectal cancer would be resistant to oxaliplatin treatment, a discovery that holds promise of improving both current treatment options and development of future treatment strategies.
Poor compliance to NCCN guidelines for adjuvant chemotherapy appears to be associated with poorer overall survival.
Research indicates that metformin can confer improved survival for patients with colorectal cancer that also have diabetes.
A very large retrospective study of patients with stage II colon cancer found adjuvant therapy improves survival, regardless of treatment regimen, patient age, or high-risk pathologic risk features.
Cbimetinib and atezolizumab was well tolerated and demonstrated encouraging clinical activity in microsatellite stable colorectal cancer (CRC).
Advanced Endoscopy Techniques May Be Safe Alternative to Surgery for Most Difficult-to-Remove or Large Polyps
Most patients with large or difficult-to-remove colorectal polyps have a lower incidence of cancer than previously thought; therefore, more advanced endoscopic techniques that spare the colon may be a better and safer alternative to a traditional operation in some cases.
Genetic biomarkers from tumor DNA circulating in the bloodstream could indicate the risk for recurrence of colorectal cancer and the efficacy of chemotherapy after surgery.
Adjuvant chemotherapy is associated with improved overall survival in patients with stage II colon cancer regardless of treatment regimen, patient age, or high-risk pathologic risk features.
Genetic mutations affecting the immune system were identified in patients who develop more than one CRC tumor at the same time, and understanding how these cancers develop could improve therapy targeting.
Screening for colorectal cancer (CRC) is not widely used by Americans age 75 years and older, even though some patients are healthy and may benefit.
The proportion of older patients with comorbidities receiving treatment for metastatic colorectal cancer (mCRC) has increased over the last 2 decades despite the overall percentage of older adults being treated remaining low.
Sign Up for Free e-newsletters
- FDA: Number of U.S. Women With Breast Implant-Caused Cancer Has Increased
- NIH Establishes Educational Program on Genomics, Genetics for Oncology Nurses
- Immunotherapy for HER2-positive Breast Cancer: Recent Advances and Combination Therapeutic Approaches
- A Review of Clinical Outcomes in Patients With Early-Stage Burkitt Lymphoma
- USPSTF Still Recommends Against Pancreatic Cancer Screening
- Oncology Nurse Navigation Facilitates Timely Treatment of Pancreatic Cancer
- Oncology Nurses Weigh In on Their Patient-Centered Communication Practices, Needs
- Substitute for Lidocaine
- CART cell therapy for prostate cancer: status and promise
- Shifting Dynamics of Social Support After a Cancer Diagnosis
- Survey Demonstrates Implicit Bias Toward Cervical Cancer Diagnoses Among Nurses, Women
- Use of Watchful Waiting Up for Low-Risk Localized Prostate Cancer
- Sharing Personal Contact Information With Patients
- Country-Specific Norms Created for Cancer-Related Quality of Life
- Nurse-Led vs Oncologist-Led Breast Cancer Follow-up Program: Early Feasibility Results of an Ongoing Study
Regimen and Drug Listings
GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION
|Head and Neck Cancer||Regimens||Drugs|