Overactive Bladder and Urinary Incontinence Treatments

Share this content:
OVERACTIVE BLADDER &
URINARY INCONTINENCE TREATMENTS
Generic Brand Strength Form Dose
ANTICHOLINERGIC
imipramine HCl Tofranil 10mg, 25mg, 50mg tabs <6yrs: Not established.
≥6yrs: Childhood enuresis: Initially 25mg daily 1hr before bedtime; after 1wk, increase to 50mg for children 6−12yrs, up to 75mg if >12yrs.
Early night bedwetters: Give 25mg in afternoon and repeat at bedtime. Max 2.5mg/kg/day.
ANTISPASMODIC/ANTICHOLINERGIC
oxybutynin chloride 5 mg scored tabs <5yrs: Not recommended.
≥5yrs: 5mg twice daily; max 15mg/day
Adults: 5mg 2−3 times a day; max 20mg/day
5mg/
 
5mL
syrup
Ditropan 
XL
5mg, 10mg, 15mg ext-rel tabs <6yrs: Not recommended.
≥6yrs: Initially 5mg once daily; may increase in 5mg increments; max 20mg/day.
Adults: Initially 5mg or 10mg once daily; may increase weekly in 5mg increments; max 30mg/day.
Gelnique 
10%
1g/
 
sachet
gel Children: Not established.
Adults: Apply one sachet once daily to dry, intact skin. Rotate application sites.
oxybutynin transdermal system Oxytrol 3.9mg/
 
day
patch Children: Not established.
Adults: Apply 1 patch twice weekly (every 3−4 days) to clean, dry area on the abdomen, hip or buttock. Rotate application sites.
BETA-3 ADRENERGIC AGONIST
mirabegron Myrbetriq 25mg, 50mg ext-rel tabs Children: Not established.
Adults: Initially 25mg once daily; may increase to 50mg once daily as needed or tolerated. Severe renal impairment or moderate hepatic impairment: max 25mg once daily.
MUSCARINIC ANTAGONIST
darifenacin HBr Enablex 7.5mg, 15mg ext-rel tabs Children: Not established.
Adults: Initially 7.5mg once daily; may increase to 15mg once daily after 2wks. Moderate hepatic impairment (Child-Pugh B), concomitant potent CYP3A4 inhibitors: max 7.5mg once daily.
fesoterodine fumarate Toviaz 4mg, 8mg ext-rel tabs Children: Not established.
Adults: 4mg once daily; may increase to max 8mg once daily. Severe renal impairment (CrCl <30mL/min) or concomitant potent CYP3A4 inhibitors: max 4mg/day.
solifenacin succinate Vesicare 5mg, 10mg tabs Children: Not established.
Adults: Initially 5mg once daily; if well tolerated, may increase to 10mg once daily. Severe renal impairment (CrCl<30mL/min), moderate hepatic impairment, or concomitant potent CYP3A4 inhibitors (eg, ketoconazole): max 5mg once daily.
tolterodine tartrate Detrol 1mg, 2mg tabs Children: Not established.
Adults: 2mg twice daily; may decrease to 1mg twice daily. Concomitant CYP3A4 inhibitors, or significant renal or hepatic dysfunction: 1mg twice daily.
Detrol LA 2mg, 4mg ext-rel caps Children: Not established.
Adults: 4mg once daily; may decrease to 2mg once daily. Concomitant CYP3A4 inhibitors, or significant renal or hepatic dysfunction: 2mg once daily.
trospium chloride 20mg tabs Children: Not established.
Adults: 20mg twice daily. ≥75yrs: 20mg once daily if twice daily dose not tolerated. Severe renal impairment (CrCl<30mL/min): 20mg once daily at bedtime.
60mg ext-rel caps Children: Not established.
Adults: 60mg daily in the AM. Severe renal impairment (CrCl<30mL/min): not recommended.
NEUROMUSCULAR BLOCKER
onabotuli-
numtoxin A
Botox 50 U/vial, 100 U/vial, 200 U/vial vacuum-dried pwd; for intra-
detrusor inj after reconsti-
tution and dilution
<18yrs: Not established.
Adults: See full labeling. Should be administered and managed by experienced physicians. Give prophylactic antibiotics 1−3 days pre‑treatment, during, and 1−3 days post‑treatment. Discontinue anti-platelet therapy ≥3 days before procedure. May premedicate with local or general anesthetic. Max dose: 100 Units/treatment; give 20 injections of 0.5mL each into the detrusor muscle via a flexible or rigid cystoscope, avoiding the trigone. May consider re‑treatment after effect of the previous injection diminishes but no sooner than 12wks. Max cumulative dose: 400 Units in a 3‑month interval.
VASOPRESSIN (SYNTHETIC)
desmo-
pressin acetate
DDAVP 0.1mg, 0.2mg scored tabs <6yrs: Not recommended.
≥6yrs: Nocturnal enuresis: individualize. Initially 0.2mg once daily at bedtime; max 0.6mg.
NOTES

Not an inclusive list of medications and/or official indications. Please see drug monograph at www.eMPR.com and/or contact company for full drug labeling.

(Rev. 4/2018)

You must be a registered member of ONA to post a comment.

Sign Up for Free e-newsletters



Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Genitourinary Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Rare Cancers Regimens
Skin Cancer Regimens Drugs