Otic Preparation Medications

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OTIC PREPARATIONS
Generic Brand Form
ANTIBIOTICS
ciprofloxacin 6% Otiprio Rx susp
ofloxacin 0.3% Rx soln
ANTIBIOTICS + CORTICOSTEROIDS
ciprofloxacin 0.3% +
dexamethasone 0.1%
Ciprodex Rx susp
ciprofloxacin 0.3% +
fluocinolone acetonide 0.025%
Otovel Rx soln
ciprofloxacin 0.2% + hydrocortisone 1% Cipro HC Otic Rx susp
colistin sulfate 3mg/mL +
neomycin sulfate 3.3mg/mL +
hydrocortisone acetate 10mg/mL +
thonzonium bromide 0.5mg/mL
Coly-Mycin S Otic1 Rx susp
Cortisporin‑TC Otic1 Rx susp
polymyxin B sulfate 10000 U/mL +
neomycin sulfate 3.5mg/mL +
hydrocortisone 10mg/mL
Rx susp
Cortisporin Otic Soln2 Rx soln
CERUMINOLYTICS
carbamide peroxide 6.5% Auro OTC soln
Debrox OTC
Murine Ear Drops OTC soln
isotonic, desalinated seawater Murine Earigate OTC spray
Murine Earigate Kids OTC reduced-pressure spray
DRYING AGENTS
isopropyl alcohol 95% +
anhydrous glycerin 5%
Auro-Dri OTC soln
Swim Ear OTC soln
STEROIDS
fluocinolone acetonide 0.01% Dermotic Oil3 Rx drops

Warming an otic product by holding the bottle in hand for 1−2 min may minimize dizziness and pain on application; do not heat above body temperature.

Classes & Pharmacology

Antibiotics: Neomycin is active against S. aureus, E. coli, H. influenzae, K. pneumoniae, Enterobacter, Neisseriae, P. aeruginosa. Neomycin can cause hearing loss and should usually not be used for more than 10 days; it can also cause sensitization. Ofloxacin is a fluoroquinolone antibiotic active against S. aureus, P. aeruginosa, P. mirabilis, S. pneumoniae, H. influenzae, M. catarrhalis. Ciprofloxacin is a fluoroquinolone antibiotic active against S. aureus, P. mirabilis, P. aeruginosa. Colistin is active against most strains of gram negative bacteria including P. aeruginosa, E. coli, K. pneumoniae, Aerobacter.

 

Corticosteroids: Hydrocortisone controls inflammation, edema, pruritus. It should not be used in the presence of local viral infections and it can impede wound healing.

 

Ceruminolytics: Carbamide peroxide mechanically softens and loosens excessive ear wax. Triethanolamine polypeptide oleate is a surfactant that breaks up cerumen.

 

Drying Agents: Isopropyl alcohol and anhydrous glycerin have surface-tension releasing properties which dislodge trapped water from the sides of the ear canal, allowing it to run out or evaporate.

 

Preservatives: Thimerosal (a mercury derivative), parabens, sulfites, oxyquinoline sulfate, or benzalkonium chloride may cause sensitization. Benzalkonium chloride also reduces surface tension.

 

Excipients and Vehicle: Propylene glycol, polysorbate 80 aid in product formulation. Products that contain hydrochloric acid should be used only in the presence of an intact eardrum.

 

Surfactants: Thonzonium bromide is a surface-active agent that promotes tissue contact by dispersion and penetration of the cellular debris and exudate.

NOTES

1Contains thimerosal; 2Contains sulfites; 3Contains peanut oil

(Rev. 6/2018)

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