Chemotherapy

Evolving Role of Radiation Therapy in the Treatment of Mesothelioma

Evolving Role of Radiation Therapy in the Treatment of Mesothelioma

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Research into the potential of radiation therapy in the management of mesothelioma may improve the prognosis, and possibly extend progression-free survival, for patients with this incurable cancer.

Elderly Patients Are Underrepresented in Trials For Soft Tissue Sarcoma

Elderly Patients Are Underrepresented in Trials For Soft Tissue Sarcoma

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With median age of participants in clinical trials for soft-tissue sarcoma younger than most patients who develop the disease, these researchers sought to determine the prevalence of including persons older than 65 in clinical trials and the efficacy of first-line chemotherapy for STS in older patients.

Progression-Free Survival Extended With PANEX Protocol in R/R Multiple Myeloma

Progression-Free Survival Extended With PANEX Protocol in R/R Multiple Myeloma

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This treatment-expansion study evaluated the tolerability and safety of the PANEX (panobinostat plus bortezomib with dexamethasone) protocol in heavily treated patients with R/R multiple myeloma.

National Cancer Drug Shortages Unknown to Many Patients

National Cancer Drug Shortages Unknown to Many Patients

A majority of study respondents reported wanting to be informed about the differences in a drug substitution's efficacy or side effects.

Taxane Acute Pain Syndrome in Cancer Therapy: Occurrence, Impact on Quality of Life

Taxane Acute Pain Syndrome in Cancer Therapy: Occurrence, Impact on Quality of Life

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Results of a prospective study of patients with breast or prostate cancer demonstrate the impact of taxane-based chemotherapy on quality of life.

Modified XELIRI Noninferior to FOLFIRI for OS in Metastatic Colorectal Cancer

Modified XELIRI Noninferior to FOLFIRI for OS in Metastatic Colorectal Cancer

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Results of the phase 3 AXEPT study were used to determine the noninferiority of a modified XELIRI regimen vs a FOLFIRI regimen in terms of overall survival among patients with metastatic colorectal cancer (mCRC).

Outcomes in SCCHN Improved With Swap of Docetaxel for 5-FU in Palliative Regimen

Outcomes in SCCHN Improved With Swap of Docetaxel for 5-FU in Palliative Regimen

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Study results show the effect on high-grade toxicity when 5-FU is replaced with docetaxel in the EXTREME regimen in the palliative treatment of patients with metastatic SCCHN.

CHEMO-SUPPORT: A Nursing Intervention to Relieve Chemotherapy Symptom Burden

CHEMO-SUPPORT: A Nursing Intervention to Relieve Chemotherapy Symptom Burden

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Results of a mixed-method study that used a combination of self-report tools evaluated the efficacy of CHEMO-SUPPORT, a patient support program designed to help patients manage their chemotherapy-related symptoms at home.

Risk for Cardiovascular Disease Higher in Survivors of Testicular Cancer

Risk for Cardiovascular Disease Higher in Survivors of Testicular Cancer

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Results from the ongoing Platinum Study revealed the prevalence of risk factors for CVD among survivors of testicular cancer who received chemotherapy for their cancer.

Managing Chemo Brain in Pediatric Survivors of Childhood Cancer

Managing Chemo Brain in Pediatric Survivors of Childhood Cancer

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Reintegration to the general environment, particularly to school, can be challenging for survivors of childhood cancers. This review discusses how adverse effects such as chemo brain may present extra challenges for these patients and what can be done to ease patients' anxiety.

FDA, ASHP Actions to Prevent or Manage Chemotherapy Drug Shortages

FDA, ASHP Actions to Prevent or Manage Chemotherapy Drug Shortages

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What is being done to address shortages of chemotherapy drugs?

Chemotherapy Transition to Outpatient Setting Maintains Care at Less Cost

Chemotherapy Transition to Outpatient Setting Maintains Care at Less Cost

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With inpatient beds at a premium, an interprofessional group sought to transition inpatient chemotherapy administration to the outpatient setting. They presented their findings at the NACNS 2018.

Clinical Nurse-Led Initiative Reduced Cancer Care Variations in Healthcare System

Clinical Nurse-Led Initiative Reduced Cancer Care Variations in Healthcare System

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A CNS-led initiative presented at the NACNS 2018 Annual Conference identified inconsistencies in oncology care, and addressed and implemented corrective measures.

Monitoring Patients With Chronic Lymphocytic Leukemia  Treated With Venetoclax

Monitoring Patients With Chronic Lymphocytic Leukemia Treated With Venetoclax

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What are key monitoring guidelines for patients with CLL being treated with venetoclax?

Hodgkin Lymphoma Treatment in EU vs US: Similarities Would Enable Worldwide Studies

Hodgkin Lymphoma Treatment in EU vs US: Similarities Would Enable Worldwide Studies

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A review of management approaches to Hodgkin lymphoma in Europe vs the United States/North America demonstrates that although some differences exist, worldwide studies that would enhance patient outcomes are feasible.

Zinc Sulfate Improves Chemotherapy-Induced Mucositis Outcomes in Leukemia

Zinc Sulfate Improves Chemotherapy-Induced Mucositis Outcomes in Leukemia

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Results of a triple-blind study demonstrate effectiveness of zinc sulfate in preventing chemotherapy-induced mucositis or reducing its incidence and severity in patients with leukemia receiving chemotherapy.

5-Year Overall Survival in Endometrial Cancer Not Improved With Chemoradiotherapy

5-Year Overall Survival in Endometrial Cancer Not Improved With Chemoradiotherapy

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A report from a phase 3 study on the 5-year failure-free survival of women with endometrial cancer treated with radiation therapy alone vs chemoradiotherapy plus adjuvant chemotherapy.

Cisplatin-Induced Adverse Events in Osteosarcoma Not Improved With Pantoprazole

Cisplatin-Induced Adverse Events in Osteosarcoma Not Improved With Pantoprazole

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This phase 2 study sought to determine whether concurrent pantoprazole would improve cisplatin-induced ototoxicity and nephrotoxicity in younger patients with osteosarcoma.

Efficacy and Safety of COX-2 Inhibitors for Advanced Non-small-cell Lung Cancer With Chemotherapy: A Meta-analysis

Efficacy and Safety of COX-2 Inhibitors for Advanced Non-small-cell Lung Cancer With Chemotherapy: A Meta-analysis

[OncoTargets and Therapy] This meta-analysis assesses the efficacy and safety profile of COX-2 inhibitors in patients with advanced non-small-cell lung cancer.

Chemotherapy-Related Fatigue Linked to Levothyroxine Use in Breast Cancer

Chemotherapy-Related Fatigue Linked to Levothyroxine Use in Breast Cancer

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In a secondary analysis of the BEATE and INVEST study, researchers followed a link between levothyroxine use, exercise, and fatigue in women with breast cancer undergoing chemotherapy.

Adjuvant Gemcitabine Regimen Improves PFS in Upper Tract Urothelial Cancer

Adjuvant Gemcitabine Regimen Improves PFS in Upper Tract Urothelial Cancer

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Investigators compared adjuvant gemcitabine plus cisplatin vs surveillance and subsequent chemotherapy if needed for patients who underwent nephron-ureterectomy for UTUC.

Pomalidomide Plus Dexamethasone Effective in R/R Multiple Myeloma

Pomalidomide Plus Dexamethasone Effective in R/R Multiple Myeloma

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Researchers report on their findings of a retrospective study that compared pomalidomide plus dexamethasone vs dexamethasone alone in patients with relapsed/refractory multiple myeloma.

Preoperative Treatment for Gastric Cancer Varies by Race, Ethnicity

Preoperative Treatment for Gastric Cancer Varies by Race, Ethnicity

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Researchers conducted a retrospective study of US patients with gastric cancer to determine what factors influenced the use of preoperative chemotherapy in this patient population.

Breast Cancer Therapies Associated With Increased Risk for Cardiovascular Disease

Breast Cancer Therapies Associated With Increased Risk for Cardiovascular Disease

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Advances in breast cancer treatment are improving outcomes for patients with the disease; however, treatments are increasing these patients' risk for cardiovascular diseases.

Cardiotoxicity Risk Greater in Blacks With Breast Cancer Receiving HER2 Therapies

Cardiotoxicity Risk Greater in Blacks With Breast Cancer Receiving HER2 Therapies

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Retrospective study examines the association between risk of cardiotoxicity and race in women with breast cancer receiving chemotherapy and at least 1 year of HER2-targeted therapy.

Oral Impairment Linked to Reduced QOL in Posttherapy Head and Neck Cancer

Oral Impairment Linked to Reduced QOL in Posttherapy Head and Neck Cancer

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Study compared the effect of treatments on quality of life in treatment-naïve patients with HNC vs those who underwent radiotherapy and/or chemotherapy, and compared with cancer-free patients.

Chemotherapy Toxicity Risk Score Use Improved Treatment Choice for Elderly

Chemotherapy Toxicity Risk Score Use Improved Treatment Choice for Elderly

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This observational study demonstrates the significance of using the chemotherapy toxicity risk score (CTRS) to determine if an elderly patient can safely tolerate standard-dose combination chemotherapy, or would fare better with a reduced-dose regimen.

Antenatal Cancer Therapy Associated With Specific Neonatal Complications

Antenatal Cancer Therapy Associated With Specific Neonatal Complications

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Cohort study assessed the effect of antenatal cancer treatment on specific neonatal complications by type of chemotherapy and by type of cancer.

Patient Support Program Provides Diversions During Chemotherapy Infusions

Patient Support Program Provides Diversions During Chemotherapy Infusions

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A kind gesture toward friends during their chemotherapy infusions developed into a support organization that helps patients pass the time during their treatment.

Hyperthermic intraperitoneal chemotherapy with surgery increases survival for epithelial ovarian cancer patients

1. Patients with stage 3 epithelial ovarian cancer treated with hyperthermic intraperitoneal chemotherapy (HIPEC) in addition to cytoreductive surgery and neoadjuvant chemotherapy experienced increased overall and recurrence-free survival compared to those treated with surgery and chemotherapy alone. 2. No difference in grade 3 or 4 adverse side effects were observed between HIPEC and non-HIPEC treated []

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