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CAMPATH
Leukemias, lymphomas, and other hematologic cancers
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Drug Name:

CAMPATH Rx

Generic Name and Formulations:
Alemtuzumab 30mg/mL; soln for IV infusion after dilution; preservative-free.

Company:
Sanofi Genzyme Company

Therapeutic Use:

Indications for CAMPATH:

B-cell chronic lymphocytic leukemia (B-CLL).

Adult:

Premedicate with antihistamine and acetaminophen before 1st dose, and at dose escalations. Give by IV infusion over 2hrs. Initially 3mg daily until infusion reactions are ≤ grade 2, then increase to 10mg daily until infusion reactions are ≤ grade 2, then to maintenance 30mg/day three times per week (on alternate days); duration of therapy (including escalation): 12 weeks. Do not exceed max single dose 30mg/dose or 90mg/week. Give PCP and herpes viral prophylaxis during treatment and for at least 2 months after completion or until CD4+ count ≥200cells/µL, whichever occurs later. Dose adjustments for neutropenia and thrombocytopenia: see full labeling. Retitrate if therapy interrupted for ≥7 days.

Children:

Not established.

Boxed Warning:

Cytopenias. Infusion reactions. Infections.

Warnings/Precautions:

Withhold dose for severe cytopenias (except lymphopenia); discontinue if autoimmune or recurrent/persistent severe cytopenias (except lymphopenia) develop. Monitor for infusion reactions; withhold dose if grade 3 or 4. Monitor for CMV infection during and for at least 2 months after completion. Withhold dose for serious infections and during antiviral treatment for CMV infection or confirmed CMV viremia. Obtain CBCs, platelet counts weekly, assess CD4+ counts after treatment until recovery to ≥200cells/µL. Pregnancy (Cat.C). Nursing mothers: not recommended.

Pharmacological Class:

Monoclonal antibody, CD52 (recombinant, humanized).

Interactions:

Avoid live virus vaccines (after recent alemtuzumab therapy). May interfere with tests using antibodies. Irradiate any blood products given (GVHD may occur).

Adverse Reactions:

Infusion reactions, cytopenias (eg, neutropenia, lymphopenia, thrombocytopenia, anemia), infections (eg, CMV), nausea, emesis, diarrhea, insomnia, anxiety.

How Supplied:

Single-use vial—1, 3

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