Bone Metastasis
Bisphosphonates vs Denosumab: Preventing SREs in Breast Cancer With Bone Metastasis
December 07, 2017A comparison study presented at the 2017 SABCS sought to determine the effectiveness of bisphosphonates with denosumab for skeletal-related events in women with breast cancer metastases to bone.
Updated ASTRO Guideline Bolsters Safety, Efficacy of Palliative RT for Bone Metastases
April 05, 2017Palliative radiotherapy for bone metastases is safe, effective — but controversy persists for single-fraction treatment.
QoL, Pain from Bone Metastases May Improve as Early as 10 Days After RT
February 13, 2017A single 8-Gy dose of radiotherapy for painful bone metastases may improve quality of life and pain as early as 10 days after administration.
Longer Dosing Interval of Zoledronic Acid May Be Acceptable for Bone Metastases
January 10, 2017Results from a phase 3 trial comparing a 12-week dosing interval with the standard 4-week dosing interval of zoledronic acid to reduce the incidence of skeletal-related events and pain in patients with bone metastases.
New Therapy Blocks Breast Cancer Cells From Entering and Hiding in Bone Marrow to Form Latent Metastases
June 16, 2016Researchers demonstrate how breast cancer cells invade bone marrow, where they escape chemotherapy and hormonal therapies that would otherwise eliminate the cancer cells.
Skeletal-related Events Linked With Worse Survival, Increased Costs
February 12, 2016Men with prostate cancer and bone metastases that have experienced at least one skeletal-related event (SRE) show worse survival, according to a recent study.
Tumor Location and Duration of Therapy Influence Palliative Effects of Radiation Therapy for Painful Bone Metastases
December 31, 2015In a review of the Dutch Bone Metastasis Study results, stratified for primary tumor location, palliative radiation therapy was found to reduce pain and improve quality of life for some patients.
Researchers Find Pathway to Cancer-Associated Muscle Weakness
October 28, 2015Cancer researchers have identified the molecular pathways that lead to cancer-associated muscle weakness. When they inhibited TGF-β, muscle function improved in mouse models of human cancers.
Process of metastasis to bone in breast cancer is identified
September 30, 2015A new study may have uncovered the key to the early detection of patients at risk of developing metastasis to bone.
New procedure tested to relieve pain from cancer that has spread to spine
July 03, 2015A new study is testing a new combination treatment that uses directly applied radiation to ease the pain from cancer that has spread to the spine.
HIV drug blocks bone metastases in prostate cancer
December 25, 2014Although prostate cancer can be successfully treated in many men, if the disease metastasizes to the bone, it is eventually lethal.
Exercise improves quality of life for patients with bone metastases
December 02, 2014Resistance training and aerobic exercise programs specifically designed to avoid injuring fragile areas of bone metastases are safe.
For patients with breast cancer, oral bisphosphonates may reduce risk for developing bone metastases
October 03, 2014Oral bisphosphonates to treat osteoporosis may also slow skeletal metastases caused by breast cancer.
Monitoring the response of bone metastases to treatment with MRI and PET
September 24, 2014The European Journal of Cancer has released a position statement on recent developments in MRI and PET and how these techniques can be used to detect bone metastases.
Single-fraction radiation therapy (SFRT) as effective as multiple-fraction (MFRT) for palliating bone metastases
August 15, 2014Standardizing prescribing practices for single-fraction radiation therapy (SFRT) for palliation of bone metastases could lead to cost savings and improvement in patients' quality of life, according to a new study.
Standard of care for delivering bisphophonates
July 28, 2014What is the preferred delivery protocol for breast cancer adjuvant bisphosphonates?
Engineered Nanoparticles Prevent Bone Cancer, Strengthen Bones
July 02, 2014Nanomedicine technologies were utilized to develop a drug-delivery system that precisely targets and attacks cancer cells in the bone. It also increases bone strength and volume to prevent bone cancer progression.
Less frequent zoledronic acid for bone metastases safe, effective
June 03, 2014In patients with breast cancer who had previously received monthly intravenous bisphosphonate therapy for bone metastases for a year or longer, maintenance zoledronic acid administered every 12 weeks was noninferior to every 4 weeks.
Model predicts therapy outcomes for prostate cancer with bone metastasis
May 19, 2014A new computational model that simulates bone metastasis of prostate cancer has the potential to rapidly assess experimental therapy outcomes and help develop personalized medicine for patients.
Dasatinib with letrozole delays disease progression for some metastatic breast cancer
January 03, 2014Adding dasatinib to the standard antihormone therapy, letrozole, doubled the time before disease progressed for women with hormone receptor-positive, HER2-negative metastatic breast cancer. These results of a phase 2 clinical trial were presented at the 2013 San Antonio Breast Cancer Symposium.
Oral drug may improve survival for patients with prostate cancer
November 28, 2013An investigational prostate cancer treatment slows the disease's progression and may increase survival, especially among men whose cancer has spread to the bones. This study adds long-term survival and safety data for the drug tasquinimod, a new candidate for treating advanced and recurrent prostate cancer.
Guidance to prevent fractures in cancer-associated bone disease
November 19, 2013The epidemiology and pathophysiology of cancer-associated bone disease was reviewed in a new paper published by an International Osteoporosis Foundation (IOF) Committee of Scientific Advisors Working Group.
RT for bone metastases in terminal cancer: More is not necessarily better
October 29, 2013Despite long-running evidence demonstrating that a single session of radiotherapy provides just as much pain relief to patients with terminal cancer as multiple treatments, the method has yet to be adopted into routine practice.
Using palliative radiotherapy to relieve bone metastasis pain
July 24, 2013Management of bone metastasis is an increasingly common challenge. Palliative radiotherapy is proving to effectively relieve pain and improve quality of life for patients.
Trastuzumab: not just for HER2-positive breast cancer anymore?
March 14, 2013The monoclonal antibody trastuzumab (Herceptin) may be effective against HER2-negative breast cancers in addition to HER2-positive disease.
Emerging cancer drugs may promote bone tumors
February 21, 2013New evidence suggests that an otherwise promising class of drugs may actually increase the risk of tumors spreading to bone. The drugs block survival signals that many cancer cells rely on to stay alive; however, targeting the same protein that makes tumors vulnerable to death also overactivates osteoclasts.
Zytiga approved for metastatic prostate cancer
January 03, 2013The FDA has expanded the indication for abiraterone acetate (Zytiga tablets) to combat metastatic castration-resistant prostate cancer.
Denosumab extended survival in lung cancer with bone metastases
December 06, 2012Denosumab improved overall survival in persons with lung cancer and bone metastases more effectively than did zoledronic acid.
Aspirin helps in some cancers
October 26, 2012Differences in the impact of aspirin in various forms of cancer are highlighted in two studies recently published in the oncology literature.
Denosumab Better for Breast Cancer With Bone Metastases
August 16, 2012Denosumab better prevents skeletal complications, ups health-related QoL versus zoledronic acid.
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