Bladder Cancer

Postresection intravesical instillation of gemcitabine decreases non-muscle-invasive urothelial cancer recurrence

1. In this randomized controlled trial, time to recurrence was lower in patient with non-muscle-invasive urothelial cancer when treated with intravesical gemcitabine as compared to saline controls. 2. There was no difference in all-cause mortality between the two treatment groups. Evidence Rating: 1 (Excellent) Study Rundown: Non-muscle-invasive urothelial cancer is the most common form of []

5-ARI Use Before, After Diagnosis Significantly Reduced Bladder Cancer-Specific Death 

5-ARI Use Before, After Diagnosis Significantly Reduced Bladder Cancer-Specific Death 

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Study results support the role of androgens and benefits of 5-alpha-reductase inhibition in the progression of bladder cancer.

Recruitment for 2 Trials of Investigational ADC for Urothelial Cancer Underway

Recruitment for 2 Trials of Investigational ADC for Urothelial Cancer Underway

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Enfortumab vedotin was granted Breakthrough Therapy Designation by the US Food and Drug Administration (FDA), based on interim results from a Phase 1 study.

Hemodialysis Indicative of Higher Mortality After Bladder Cancer Surgery

Hemodialysis Indicative of Higher Mortality After Bladder Cancer Surgery

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Patients on hemodialysis that underwent radical cystectomy for bladder cancer experienced increased mortality.

Liquid Biopsy Results Could Guide, Expedite Clinical Trial Enrollment 

Liquid Biopsy Results Could Guide, Expedite Clinical Trial Enrollment 

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Researchers assessed the use of cfDNA-based liquid biopsy to guide and expedite clinical trial enrollment for patients with with metastatic urothelial carcinoma.

Risk for Bladder Cancer Higher With a History of Urinary Calculi 

Risk for Bladder Cancer Higher With a History of Urinary Calculi 

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A meta-analysis indicates that a history of urinary calculi could increase a person's risks for developing bladder cancer.

Radical Cystectomy Outcomes Worsen With Higher Stage Chronic Kidney Disease 

Radical Cystectomy Outcomes Worsen With Higher Stage Chronic Kidney Disease 

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The presence of CKD may increase chances for poor outcomes following radical cystectomy for urothelial carcinoma of the bladder.

Cardiopulmonary Fitness Leads to Better Outcomes in Bladder Cancer Surgery

Cardiopulmonary Fitness Leads to Better Outcomes in Bladder Cancer Surgery

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A feasibility study involving 60 patients with bladder cancer sought to determine if preoperative vigorous cardiovascular activity would improve postsurgical outcomes.

New Tool Identifies Mortality Risk After Bladder Cancer Surgery

New Tool Identifies Mortality Risk After Bladder Cancer Surgery

Tool incorporates the relative contribution of tumor stage and lymph node involvement.

First-line Pembrolizumab May Be Efficacious for Cisplatin-ineligible Urothelial Cancer

First-line Pembrolizumab May Be Efficacious for Cisplatin-ineligible Urothelial Cancer

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Approximately 50% of patients with advanced urothelial carcinoma are unable to receive standard first-line cisplatin-based chemotherapy, indicating a need for additional treatment options.

Risk of Bladder Recurrence Reduced With Chemotherapy Flush After Tumor Resection

Risk of Bladder Recurrence Reduced With Chemotherapy Flush After Tumor Resection

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Flushing the bladder with a chemotherapeutic agent after tumor resection significantly reduced recurrence rates of bladder cancer.

Use of Checkpoint Inhibitors in Urothelial Carcinoma

Use of Checkpoint Inhibitors in Urothelial Carcinoma

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Studies presented in the last year demonstrated a revolutionary role for immune checkpoint inhibitors in the treatment of urothelial carcinoma.

Chemo + Radiotherapy Efficacious in Muscle-invasive Bladder Cancer

Chemo + Radiotherapy Efficacious in Muscle-invasive Bladder Cancer

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Adding chemotherapy with fluorouracil and mitomycin to radiotherapy improves locoregional control.

Pembrolizumab Active Against Rare Melanoma, Extends Survival in Bladder Cancer

Pembrolizumab Active Against Rare Melanoma, Extends Survival in Bladder Cancer

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Clinical trials show pembrolizumab active against mucosal melanoma, extends survival in bladder cancer.

Nivolumab Approved for Locally Advanced or Metastatic Bladder Cancer

Nivolumab Approved for Locally Advanced or Metastatic Bladder Cancer

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The US Food and Drug Administration has approved nivolumab (Opdivo) for the treatment of patients with locally advanced or metastatic bladder cancer.

How We Developed a New Protocol for Treatment of Urethral Carcinoma

How We Developed a New Protocol for Treatment of Urethral Carcinoma

Faced with a harsh treatment option, a patient with genitourinary cancer helps create a treatment plan that preserves his self-image.

Smoking-related Cancer Deaths Highest in Southern United States

Smoking-related Cancer Deaths Highest in Southern United States

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Smoking-attributable cancer mortality estimates have not been established by state; therefore, in this study, the proportion of cancer deaths among persons 35 years and older related to cigarette smoking in 2014 was calculated for each state and DC.

New Research Identifies Potential Bladder Cancer Chemotherapy Side Effect

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A recent study undertaken sought to examine the effects of chemotherapy on bladder cancer cells and possible connections to later treatment resistance.

Nivolumab Monotherapy Active in Recurrent Metastatic Urothelial Carcinoma

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Single-agent nivolumab induced durable clinical responses with a manageable safety profile in previously treated patients with locally advanced or metastatic urothelial carcinoma.

Mycobacteria Treatment for Bladder Cancer More Effective With Emulsification in Olive Oil

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Emulsifying Mycobacterium brumae in olive oil appeared promising for producing a robust immune response in preclinical tests. Recent research has indicated that M brumae is a safer alternative to BCG.

Atezolizumab Approved for Locally Advanced or Metastatic Urothelial Carcinoma

Atezolizumab Approved for Locally Advanced or Metastatic Urothelial Carcinoma

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US FDA granted accelerated approval to atezolizumab (TECENTRIQ), indicated for the treatment of locally advanced or metastatic UC in patients whose disease progressed during or following platinum-based chemotherapy, or in the neoadjuvant or adjuvant setting.

Well Water a Suspected Cause of Bladder Cancer in New England

Well Water a Suspected Cause of Bladder Cancer in New England

Researchers believe arsenic exposure might contribute to higher-than-normal rates of bladder cancer in the region.

Risk of Bladder Cancer Higher for Patients Taking a Specific Diabetes Medication

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Pioglitazone use correlated with increased rates of bladder cancer across a large population. The risk of developing bladder cancer also increased with higher dose and longer use of the drug.

Adaptive IGRT for Urinary Bladder Cancer Is Clinically Feasible With Good Outcomes

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A bladder preservation rate of 83% occurred at 3 years after a trimodality treatment approach for localized bladder cancer that used adaptive image-guided, intensity-modulated radiation therapy (IG-IMRT).

ASCO Endorses European Association of Urology Guideline on Bladder Cancer

ASCO Endorses European Association of Urology Guideline on Bladder Cancer

Guideline on muscle-invasive and metastatic bladder cancer, with qualifying statements

Diagnostic Tool Can Smell Bladder Cancer or Prostate Cancer in a Urine Sample

Diagnostic Tool Can Smell Bladder Cancer or Prostate Cancer in a Urine Sample

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Recent developments in a gas chromatography tool might allow doctors to determine whether urologic cancers are present via a urine sample.

Adjuvant Chemo Associated With Improved Survival in Locally Advanced Bladder Cancer

Adjuvant Chemo Associated With Improved Survival in Locally Advanced Bladder Cancer

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Adjuvant chemotherapy was associated with improved survival in patients with locally advanced bladder cancer.

Mental Health Status May Impact Bladder Cancer Surgery Outcomes

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Mental health status prior to bladder cancer surgery may be associated with postoperative outcomes.

Investigational Immunotherapeutic Approach Increased Survival in Patients With Bladder Cancer

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A novel immunotherapeutic approach improved outcomes for patients with advanced bladder cancer, according to a recent study.

Researchers develop a more efficient process for identifying personalized bladder cancer treatment

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Researchers developed a way to personalize treatments for aggressive bladder cancer. Taking bladder tumors from individual patients, identifying actionable mutations, and grafting the tumors into mice, researchers were able to simultaneously test multiple therapies in the tumor models.

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