Generic Name and Formulations:
Rasagiline 0.5mg, 1mg; tabs.
Indications for AZILECT:
Parkinson's disease (PD).
Monotherapy or adjunct without levodopa: 1mg once daily. Concomitant levodopa with/without other PD drugs (eg, dopamine agonist, amantadine, anticholinergics): initially 0.5mg once daily; may increase to 1mg once daily (consider reducing levodopa dose based on response). Mild hepatic impairment (Child-Pugh score 5–6) or concomitant CYP1A2 inhibitors: 0.5mg once daily.
During or within 2 weeks of meperidine, tramadol, methadone, propoxyphene, MAOIs including other selective MAO-B inhibitors. Concomitant dextromethorphan, St. John's wort, cyclobenzaprine.
Monitor for new onset hypertension or hypertension that is not adequately controlled after starting therapy. Avoid tyramine-rich foods (see full labeling). Monitor for drowsiness or sleepiness. Mild hepatic impairment: reduce dose; moderate to severe hepatic impairment (Child-Pugh score ≥7): not recommended. Monitor for hallucinations, psychotic or compulsive behaviors; consider reduce dose or discontinue if develops. Monitor for melanoma. Pregnancy (Cat.C). Nursing mothers.
See Contraindications. Possible hypertensive crisis with excess dietary tyramine (see full labeling). Potentiated by CYP1A2 inhibitors (eg, ciprofloxacin). Concomitant antidepressants (eg, SSRIs, SNRIs, triazolopyridines, tricyclics, tetracyclics): not recommended; increased risk of serotonin syndrome. Allow at least 14 days after discontinuing rasagiline before starting SSRIs, SNRIs, triazolpyridines, tricyclics, tetracyclics; allow 5 weeks after discontinuing fluoxetine before starting rasagiline. Caution with sympathomimetics (eg, nasal, oral, ophthalmic decongestants or cold remedies).
As monotherapy: flu syndrome, arthralgia, depression, dyspepsia. With levodopa: also dyskinesia, accidental injury, weight loss, postural hypotension, GI upset, anorexia, abdominal pain, constipation, dry mouth, rash, abnormal dreams, fall.
Sign Up for Free e-newsletters
- Choice of Breast Reconstruction After Mastectomy Affects Satisfaction, Quality of Life
- Bariatric Surgery Reduced Risk of Some Cancers in Obese Patients
- Carfilzomib Benefits May Outweigh Cardiovascular Risk in Multiple Myeloma
- The Caregivers' Cancer Journey
- Genetic Link Between Depression and Breast Cancer Remains Unclear
- Implementing an Ambulatory Adherence Program May Improve Oral Anticancer Medications Compliance
- Exercise Habits Influence Mortality in Adult Survivors of Childhood Cancer
- Managing Dyspnea With Fentanyl in Patients With Cancer at End of Life
- CALM: A Depression Intervention for Cancer Patients at the End of Life
- High BMI Among Premenopausal Women May Improve Risk for Breast Cancer
- Fertility Preservation in Hodgkin's Lymphoma Patients That Undergo Targeted Molecular Therapies: An Important Step Forward From the Chemotherapy Era
- Survey of ACEP Councilors Reveals NP, PA Staffing Models, Practice Patterns Vary
- Breath Analysis May Be an Effective Diagnostic for Pancreatic Cancer
- Genetic Susceptibility to Pancreatic Cancer Linked to 6 Specific Gene Mutations
- Dinner Hour and Sleep Habits Affect Risk of Breast, Prostate Cancers
Regimen and Drug Listings
GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION
|Head and Neck Cancer||Regimens||Drugs|