At a Glance The definition of clopidogrel “resistance” or residual platelet reactivity (RPR) is suboptimal inhibition of platelet function, despite therapy with clopidogrel. Loss of function alleles for CYP2C19 (*2, *3, others) are associated with a decreased metabolism of clopidogrel to its active form. Conversely, the gain of function allele (*17) is associated with increased…
At a Glance Unlike aspirin and Clopidogrel, there is no medical definition of Prasugrel resistance. Prasugrel is indicated for patients that demonstrate Clopidogrel resistance or recurrent ischemic events while receiving dual antiplatelet therapy with aspirin and Clopidogrel. Prasugrel is a third generation thienopyridine prodrug converted to an active metabolite, R-138727, by the hepatic cytochrome P450…
At a Glance Aspirin resistance is defined as residual platelet activity despite aspirin therapy. A patient may have aspirin resistance if he or she develops a stroke or myocardial infarction while on aspirin therapy as a result of a prior episode of unstable angina/acute coronary syndrome or acute myocardial infarction. Aspirin is rapidly bound to…
