Atracurium Besylate Injection Rx
Generic Name and Formulations:
Atracurium besylate 10mg/mL; soln for IV inj.
Various generic manufacturers
Indications for Atracurium Besylate Injection:
Adjunct to general anesthesia to facilitate endotracheal intubation, and to provide skeletal muscle relaxation during surgery or mechanical ventilation.
Adults and Children:
<1month: not recommended. Individualize. 1month to 2yrs (under halothane anesthesia): initially 0.3–0.4mg/kg. ≥2yrs: initially 0.4–0.5mg/kg IV bolus. Inhalation anesthetics (eg, enflurane, isoflurane): 0.25–0.35mg/kg. Prolonged surgery: maintenance dose of 0.08–0.10mg/kg, usually given 20–45 minutes after initial inj dose. Intubation with succinylcholine, significant cardiovascular disease, history of severe anaphylaxis or asthma: initially 0.3–0.4mg/kg given slowly or in divided doses over 1 minute. Neuromuscular disease, severe electrolyte disorders, or carcinomatosis: consider dose reductions. Use by continuous infusion: see literature. Monitor with a peripheral nerve stimulator to avoid overdosage.
Hypersensitivity to benzyl alcohol (multidose vials).
To be administered under the supervision of experienced clinicians. Have intubation, artificial respiration, oxygen therapy and reversal agents available. Not for IM administration. Increased risk of substantial histamine release (eg, cardiovascular disease, severe anaphylaxis or asthma history). Myasthenia gravis or myasthenic (Eaton-Lambert) syndrome. Severe electrolyte disorders or carcinomatosis. Malignant hyperthermia. Resistance may develop in burn patients. Bronchial asthma. Long-term use in I.C.U. Neonates. Elderly. Labor & delivery. Pregnancy (Cat.C). Nursing mothers.
Prior administration of succinylcholine may potentiate effects (give atracurium only after succinylcholine recovery). Potentiated by volatile inhalational anesthetics (eg, enflurane, isoflurane, halothane), aminoglycosides, polymyxins, lithium, magnesium salts, procainamide, quinidine. Concomitant other muscle relaxants may have synergistic or antagonistic effects.
Neuromuscular blocker (nondepolarizing).
Skin flushing, erythema, tachycardia, inadequate or prolonged musculoskeletal block, hypotension, bradycardia, dyspnea; rare: seizures, severe hypersensitivity reactions.
Formerly known under the brand name Tracrium.
Sign Up for Free e-newsletters
- Chemotherapy-Related Fatigue Linked to Levothyroxine Use in Breast Cancer
- New Hypertension Threshold Guides Blood Pressure Management During Cancer Treatment
- Sexual Aids and Resources Not Readily Available at Cancer Centers
- Factors Affecting Employment Participation in Early-stage Breast Cancer
- Gas Mixture Improves Efficacy of Breakthrough Cancer Pain Treatment
- Sitting With Silence in End-of-Life Cancer Care
- Obesity and Cancer Risk (Fact Sheet)
- Susceptibility Gene Mutations Common in Those With Pancreatic Cancer and History of Other Cancers
- Anticancer Properties of Omega-3 Fatty Acids: Plant-Based vs Marine-Based
- US Pharmacopeia Revises Chapter on Handling Hazardous Drugs
- Follow-Up After Treatment Lacking for Younger Cancer Survivors
- Adjuvant Vemurafenib Does Not Improve Disease-Free Survival in Melanoma
- Profile of Buparlisib and its Potential in the Treatment of Breast Cancer: Evidence to Date
- Exercise Before Lung Cancer Surgery Greatly Reduces Complications
- Hodgkin Lymphoma Treatment in EU vs US: Similarities Would Enable Worldwide Studies
Regimen and Drug Listings
GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION
|Head and Neck Cancer||Regimens||Drugs|