Head and Neck Cancer Survival Improved When irAEs Occur During Anti-PD-1 Therapy

Share this content:
In this prospective study, investigators identified 114 patients unselected for PD-L1 status and treated them with anti-PD-1 therapy.
In this prospective study, investigators identified 114 patients unselected for PD-L1 status and treated them with anti-PD-1 therapy.
The following article features coverage from the American Society of Clinical Oncology (ASCO) 2018 meeting. Click here to read more of Cancer Therapy Advisor's conference coverage.

Experiencing immune-related adverse events (irAEs) during the course of anti-programmed death-receptor-1 (PD-1) therapy may be correlated with improved survival and response outcomes among patients with head and neck cancer (HNC), according to findings in poster presentation at the American Society of Clinical Oncology 2018 Annual Meeting on Saturday, June 2.1

It is thought that immune competence may modify antitumor response with anti-PD-1 therapy. Researchers evaluated whether the development of irAEsc—defined as any immune-mediated adverse effects — among patients with metastatic HNC who have failed platinum-based chemotherapy would be associated with improved outcomes.

For this prospective study, investigators identified 114 patients unselected for PD-L1 status and treated them with anti-PD-1 therapy. Median follow-up was 8.9 months. Baseline characteristics, including PD-L1-positivity, were comparable between the two study arms.

Overall, 59 irAEs occurred in 49 of 108 evaluable patients; 20 dermatologic, 15 musculoskeletal, 14 endocrine, 6 hepatic, 2 ophthalmologic, and 1 pulmonary and gastrointestinal iRAEs were reported. Five patients (10.2%) experienced a grade 3 or higher irAE.

The overall response rate (ORR) was 30.6% among patients who experienced irAEs compared with 12.3% among patients who did not develop any irAEs (P = .02). The median progression-free survival (PFS) was 6.9 months and 2.1 months among patients who were irAE-positive and negative, respectively (P = .0004), and the median overall survival (OS) was nearly doubled among patients who were irAE-positive (12.5 months vs 6.8 months; P = .007).

A multivariable analysis revealed that the incidence of irAEs was independently associated with enhanced ORR (P = .03), PFS (P = .009), and OS (P = .003).

The authors concluded that “the ability to develop irAEs may be an indicator of immune competence and determining patient immune competence more accurately may be clinically useful.”

Reference

Foster CC, Kochanny S, Khattri A, et al. Association of immune-related adverse events (irAEs) with improved response, progression-free survival, and overall survival for patients with metastatic head and neck cancer receiving anti-PD-1 therapy. Poster presentation at: 2018 ASCO Annual Meeting; June 1-5, 2018; Chicago, IL.

You must be a registered member of ONA to post a comment.

Sign Up for Free e-newsletters



Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Genitourinary Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Rare Cancers Regimens
Skin Cancer Regimens Drugs