Generic Name and Formulations:
Tirofiban (as HCl monohydrate) 50mcg/mL; per bag or vial; soln for IV infusion; 250mcg/mL; per vial; soln for IV bolus.
Medicure Pharma, Inc.
Indications for AGGRASTAT:
To reduce the rate of thrombotic cardiovascular events (combined endpoint of death, MI, or refractory ischemia/repeat cardiac procedure) in patients with non-ST elevation acute coronary syndrome.
May give bolus dose via a syringe or IV pump. Administer 25mcg/kg intravenously within 5mins and then 0.15mcg/kg/min via IV infusion pump for up to 18hrs. Renal impairment (CrCl ≤60mL/min): 25mcg/kg intravenously within 5mins and then 0.075mcg/kg/min for up to 18hrs.
Within previous 30 days: active internal bleeding, bleeding diathesis, major surgery, or severe physical trauma. History of thrombocytopenia after previous tirofiban therapy.
Monitor platelet counts 6hrs after initiation and daily thereafter. If platelet decreases to <90,000/mm3, monitor to exclude pseudothrombocytopenia. Discontinue tirofiban (and heparin) if thrombocytopenia confirmed. Previous exposure to a GP IIb/IIIa blocker may increase risk of thrombocytopenia. Minimize other arterial and venous punctures, IM injections, catheter use, nasotracheal intubation to lower bleeding risk. Severe renal insufficiency. Hemodialysis. Pregnancy (Cat.B). Nursing mothers: not recommended.
Increased risk of bleeding with concomitant fibrinolytics, anticoagulants, antiplatelets.
Bleeding (may be fatal), pelvic pain, bradycardia, coronary artery dissection; thrombocytopenia, anaphylaxis.
Premixed bag (100mL, 250mL)—1; Premixed vial (100mL)—1; Premixed bolus vial (15mL)—1
Sign Up for Free e-newsletters
- Real World Results May Not Mirror Clinical Study Outcomes in Multiple Myeloma
- Is Radioimmunotherapy a Path Forward for Melanoma?
- Handling Chemotherapy Premedications
- FDA Approves Mogamulizumab-kpkc for Rare Subtypes of Non-Hodgkin Lymphoma
- New PDL1 Inhibitors for Non-small Cell Lung Cancer: Focus on Pembrolizumab
- NCCIH HerbList App Launched to Provide Information on Herbal Products
- Metformin Use May Improve Survival Outcomes in Bladder Cancer
- Higher Vitamin D Levels Associated With Lower Breast Cancer Risk
- Nurse-Led Program Improves Health, Financial Outcomes in Outpatient Chemotherapy
- Seeking Reliable Information on Herbal Products
- Disparities Remain in Prevalence of Cancer Screening Tests
- Hope, Gratitude, and Spirituality: What They Mean to Cancer Patients
- FDA, EU Approvals Sought for Split Dose Regimen of Daratumumab for Multiple Myeloma
- 8 Hours of Bedrest May Be Ideal After Intrathecal Chemotherapy in Hematologic Cancers
- Combined Digital Screening Best for Detecting Breast Cancers
Regimen and Drug Listings
GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION
|Head and Neck Cancer||Regimens||Drugs|