Adverse Effects

Nonmyeloablative/Reduced-Intensity Conditioning May Reduce Mucositis in HCT

Nonmyeloablative/Reduced-Intensity Conditioning May Reduce Mucositis in HCT

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Researchers sought to determine if NMA or reduced-intensity conditioning with busulfan improved severity/duration of oral mucositis compared with myeloablative conditioning in patients with hematologic cancer undergoing HCT.

FDA, EU Approvals Sought for Split Dose Regimen of Daratumumab for Multiple Myeloma

FDA, EU Approvals Sought for Split Dose Regimen of Daratumumab for Multiple Myeloma

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The manufacturer of daratumumab, a CD38-directed antibody for the treatment of multiple myeloma, has submitted a sBLA and a type II variation to the US FDA and European Medicines Agency, respectively, for approval of a split dosing regimen.

8 Hours of Bedrest May Be Ideal After Intrathecal Chemotherapy in Hematologic Cancers

8 Hours of Bedrest May Be Ideal After Intrathecal Chemotherapy in Hematologic Cancers

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In an open-label study, researchers sought to determine the optimal amount of bed rest after intrathecal chemotherapy for patients with hematologic cancers.

Assessing Direct Costs of Treatment-Related Adverse Events in Advanced Melanoma

Assessing Direct Costs of Treatment-Related Adverse Events in Advanced Melanoma

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In a systematic review, researchers explored the financial burden of treating grade 3 to 4 adverse events associated with melanoma and its treatment.

Healthcare Use, Economic Burden Greater With Cancer-Related Opioid-Induced Constipation

Healthcare Use, Economic Burden Greater With Cancer-Related Opioid-Induced Constipation

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Use of opioids to manage cancer-related pain may have adverse effects of its own that can have a significant impact on healthcare use among patients with cancer.

Carfilzomib Benefits May Outweigh Cardiovascular Risk in Multiple Myeloma

Carfilzomib Benefits May Outweigh Cardiovascular Risk in Multiple Myeloma

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In an analysis of 11 studies, researchers investigated whether the benefits of carfilzomib for multiple myeloma outweigh the cardiovascular risks. However, the researchers recommend careful monitoring and management of blood pressure and volume status as good clinical practice, regardless.

Genetic Link Between Depression and Breast Cancer Remains Unclear

Genetic Link Between Depression and Breast Cancer Remains Unclear

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In this study, researchers sought to determine if a genetic predisposition to depression exists in some patients with breast cancer and how to identify it.

Chinese Traditional Medicine Showed Effectiveness on Pain, Quality of Life in Advanced Cancer

Chinese Traditional Medicine Showed Effectiveness on Pain, Quality of Life in Advanced Cancer

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In a randomized study, researchers sought to determine the effect of IV injections of coix seed oil, a Chinese CAM, on pain and quality of life measures for patients with advanced cancer.

Handgrip Force May Provide Objective Evaluation of Cancer-Related Fatigue

Handgrip Force May Provide Objective Evaluation of Cancer-Related Fatigue

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Researchers sought to determine if handgrip force could provide objective measures of CRF in patients with cancer.

CALM: A Depression Intervention for Cancer Patients at the End of Life

CALM: A Depression Intervention for Cancer Patients at the End of Life

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The effectiveness of a novel intervention intended to reduce and/or prevent depression in patients with advanced cancer at the end of life was investigated in a randomized study with more than 300 patients.

Live or Online Mindfulness-Based Cognitive Therapy Reduced Cancer-Related Psychological Distress

Live or Online Mindfulness-Based Cognitive Therapy Reduced Cancer-Related Psychological Distress

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Mindfulness-based interventions are proven effective in helping patients with cancer manage distress and other psychological symptoms. In this study, researchers sought to determine if Internet-based MBCT can be as effective as face-to-face interventions.

PTSD May Increase Symptom Burden in Patients With Cancer

PTSD May Increase Symptom Burden in Patients With Cancer

Post-traumatic stress symptoms are linked to a greater symptom burden in hospitalized cancer patients.

Managing Dyspnea With Fentanyl in Patients With Cancer at End of Life

Managing Dyspnea With Fentanyl in Patients With Cancer at End of Life

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In this retrospective study, researchers sought to determine the effectiveness of fentanyl for dyspnea in dying patients with advanced cancer.

Malnutrition, Decreased QOL Possible After Radiation Therapy for Head and Neck Cancer

Malnutrition, Decreased QOL Possible After Radiation Therapy for Head and Neck Cancer

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In a retrospective study, researchers used established tools to measure the nutritional status of patients with head and neck cancer before, immediately after, and at 2 follow-up points after radiotherapy.

Ixazomib, Lenalidomide, Dexamethasone Effective But Increases Toxicity in Multiple Myeloma

Ixazomib, Lenalidomide, Dexamethasone Effective But Increases Toxicity in Multiple Myeloma

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Three-drug regimen twice a week achieved good response and long-term outcomes in patients with newly diagnosed multiple myeloma; however, regimen has higher toxicity than once weekly dose.

Low-Dose Dasatinib for Chronic-Phase CML Safe, Effective With Fewer Adverse Events

Low-Dose Dasatinib for Chronic-Phase CML Safe, Effective With Fewer Adverse Events

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In this study, researchers assigned 75 patients with newly diagnosed Philadelphia chromosome (Ph)-positive CML-CP to receive dasatinib 50 mg once daily.

Childhood Neuroblastoma Survivors at Risk for Psych Impairment

Childhood Neuroblastoma Survivors at Risk for Psych Impairment

Psychological impairment seen particularly in survivors with chronic health conditions.

Navigating the Benefits and Challenges of Immunotherapy

Navigating the Benefits and Challenges of Immunotherapy

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A review of immunotherapy — what they are, how they work, and what to watch for — was presented at the 2018 ONA Navigation Summit.

Muscle Loss Not Always Correlated With Loss of Function, Strength in Cancer Cachexia

Muscle Loss Not Always Correlated With Loss of Function, Strength in Cancer Cachexia

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Interventions specifically designed to target cachexia in patients with thoracic or gastrointestinal cancer and established cachexia were effective in helping patients preserve functional stability and rehabilitation potential.

Association Between Multiple Myeloma With VTE and Increased Mortality at 2, 5 Years

Association Between Multiple Myeloma With VTE and Increased Mortality at 2, 5 Years

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A study presented at the 2018 ASCO Annual Meeting investigated the mortality risk for patients with multiple myeloma who develop VTE.

Primary Prophylaxis Key in Reducing Febrile Neutropenia in Early Breast Cancer

Primary Prophylaxis Key in Reducing Febrile Neutropenia in Early Breast Cancer

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In a retrospective study, researchers investigated the effect of primary prophylaxis on incidence of febrile neutropenia in patients with early stage breast cancer.

Head and Neck Cancer Survival Improved When irAEs Occur During Anti-PD-1 Therapy

Head and Neck Cancer Survival Improved When irAEs Occur During Anti-PD-1 Therapy

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Researchers evaluated whether the development of irAEsc among patients with metastatic head and neck cancer who have failed platinum-based chemotherapy could improve patient outcomes.

Palliative Issues Inadequately Addressed Among Hospitalized Cancer Patients

Palliative Issues Inadequately Addressed Among Hospitalized Cancer Patients

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Consultations for palliative care for hospitalized highly symptomatic patients with cancer is low regardless of curability or whether patient has hematologic or solid cancer, a study presented at 2018 ASCO has shown.

Severe Folate Deficiency Associated With Olaparib for Relapsed Ovarian Cancer

Severe Folate Deficiency Associated With Olaparib for Relapsed Ovarian Cancer

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In a case study, olaparib was found to induce folate deficiency in most patients with relapsed ovarian cancer. Researchers discuss the significance of this adverse effect and how it was managed.

Patient Advocacy, Questioning 'Status Quo,' Improves Safety in Ambulatory Infusion Setting

Patient Advocacy, Questioning 'Status Quo,' Improves Safety in Ambulatory Infusion Setting

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In fielding reports of CNS-related adverse effects from patients in the ambulatory infusion room, nurses were able to prompt a pharmacy practice review. The outcomes of the resulting switch in premedication for HSR was presented at the 2018 ONS Annual Congress.

Peripheral Neuropathy Frequent for Childhood Cancer Survivors

Peripheral Neuropathy Frequent for Childhood Cancer Survivors

Long-term neurotoxicity was more frequently seen with cisplatin than with vinca alkaloids, data indicates.

NP-Led Clinics Improved Phase 1 Oncology Study Operations, Outcomes

NP-Led Clinics Improved Phase 1 Oncology Study Operations, Outcomes

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A clinic staffed with clinical research nurses provided needed care for patients in clinical trials who experienced adverse effects, and also ensured consistent documentation of treatment-related AEs, according to a presentation at the 2018 ONS Annual Congress.

Simple Adjustment Key to Paclitaxel Infusion Protocol That Reduced Hypersensitivity Reactions

Simple Adjustment Key to Paclitaxel Infusion Protocol That Reduced Hypersensitivity Reactions

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A project presented at the 2018 ONS Annual Congress demonstrated the effectiveness of standardizing nursing practices for paclitaxel infusions.

Posttreatment Visual Function, Ocular Symptoms Impact QOL in Head and Neck Cancer

Posttreatment Visual Function, Ocular Symptoms Impact QOL in Head and Neck Cancer

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A link between visual function, ocular symptoms, and quality of life was found in cross-sectional study of patients who underwent radiotherapy for head and neck cancers, according to a presentation at the 2018 ONS Annual Congress.

Electronic Self-Report Assessment-Cancer May Preserve Physical Function in Chemotherapy-Induced Peripheral Neuropathy

Electronic Self-Report Assessment-Cancer May Preserve Physical Function in Chemotherapy-Induced Peripheral Neuropathy

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Research presented at the 2018 ONS Congress reported on the effectiveness of ESRA-C, a web-based assessment and self-care intervention program, in the management of CIPN in patients receiving platinum and/or taxane-based chemotherapy.

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