Adverse Effects

CIPN in Breast Cancer: Do Subjective and Objective Measures Correlate?

CIPN in Breast Cancer: Do Subjective and Objective Measures Correlate?

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Researchers sought to determine how subjective measures of CIPN correlated with objective measures of CIPN.

Patients, Physicians Do Not Recognize Fatigue the Same

Patients, Physicians Do Not Recognize Fatigue the Same

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A worldwide survey reveals that despite similar perceptions on symptom burden of ITP, patients and physicians do not agree on the effect of fatigue on quality of life.

ADT May Up Risk for Heart Failure in Prostate Cancer Patients

ADT May Up Risk for Heart Failure in Prostate Cancer Patients

Heart failure risk was found to be higher for androgen deprivation therapy users in a propensity score-matched analysis.

Lung Cancer-Specific Distress Screening Tool Not Needed But Has Potential Benefit

Lung Cancer-Specific Distress Screening Tool Not Needed But Has Potential Benefit

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Using focus groups, researchers evaluated patient-reported psychosocial consequences of lung cancer to determine if a lung cancer-specific distress screening instrument would benefit these patients.

Report From Childhood Cancer Survivor Study Identifies Long-Term Risks for VTE

Report From Childhood Cancer Survivor Study Identifies Long-Term Risks for VTE

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Assessment of long-term risks for VTE based on data from almost 30,000 childhood cancer survivors and siblings, with approximately 21 years of follow-up.

Hodgkin Lymphoma Survivorship Marked by Periods of Actionable Distress

Hodgkin Lymphoma Survivorship Marked by Periods of Actionable Distress

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A retrospective evaluation of patients treated at a tertiary cancer center demonstrated that patients with Hodgkin lymphoma experienced periods of actionable distress in survivorship, despite a low overall distress burden.

Commission Seeks Standardized Adverse Event Assessments in Hematologic Malignancies

Commission Seeks Standardized Adverse Event Assessments in Hematologic Malignancies

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A snapshot of an international Commission's report on the issues inherent with adverse event reports of hematologic malingnancies in clinical trials.

ASCO, SITC Release Recommendations for Clinical Trial Reporting of Immunotherapy Adverse Events

ASCO, SITC Release Recommendations for Clinical Trial Reporting of Immunotherapy Adverse Events

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As immunotherapies gain a stronger foothold as a treatment option for cancer, ASCO and SITC convened a panel to develop recommendations to ensure consistent and efficient clinical trial reporting in immuno-oncology.

Predictive Role of Skin Rash in Advanced Pancreatic Cancer Patients Treated With Gemcitabine Plus Erlotinib: A Systematic Review and Meta-analysis

Predictive Role of Skin Rash in Advanced Pancreatic Cancer Patients Treated With Gemcitabine Plus Erlotinib: A Systematic Review and Meta-analysis

[OncoTargets and Therapy] In this systematic review and meta-analysis, researchers sought to determine the predictive value of skin rash in patients with advanced pancreatic cancer treated with gemcitabine plus erlotinib.

Chemotherapy Side Effects in Women vs Men: Broader Range, More Severe

Chemotherapy Side Effects in Women vs Men: Broader Range, More Severe

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An analysis of pooled data from 4 randomized controlled clinical trials revealed that male and female patients experience different chemotherapy side effects and at different severities, according to a poster presented at ESMO 2018 Congress.

Strength and Hope for Women in the Mist of Cancer

Strength and Hope for Women in the Mist of Cancer

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A review of the most feared effects of breast cancer treatment and resources to recommend to patients coping with these effects.

Prospective Study Measures Cognitive, Treatment Effects in Older Breast Cancer Survivors

Prospective Study Measures Cognitive, Treatment Effects in Older Breast Cancer Survivors

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Thinking and Living With Cancer (TLC) sought to determine the effects of breast cancer treatment and age on cognitive function in older breast cancer survivors over time.

Immune Checkpoint Inhibitor Therapy May Affect Thyroid Function

Immune Checkpoint Inhibitor Therapy May Affect Thyroid Function

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A review of medical records revealed that thyroid function may be affected by immune checkpoint inhibitor therapy, and these patients should undergo thyroid function tests, especially during the first 8 weeks of therapy.

Hypofractionated Radiotherapy After Conservative Surgery May Increase Low-intermediate Grade Late Fibrosis in Breast Cancer Patients

Hypofractionated Radiotherapy After Conservative Surgery May Increase Low-intermediate Grade Late Fibrosis in Breast Cancer Patients

[Breast Cancer: Targets and Therapy] Researchers sought to determine the incidence of subcutaneous side effects in patients with early-stage breast cancer treated with AHF-RT vs standard fractionated RT after breast conserving surgery.

Self-Care Toolkits Ease Negative PostSurgery Experiences for Patients With Breast Cancer

Self-Care Toolkits Ease Negative PostSurgery Experiences for Patients With Breast Cancer

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Self-care toolkits were found to reduce pain and other negative postsurgical experiences for women undergoing surgical procedures for breast cancer.

Assessment Tool for Immunotherapy Side Effects

Assessment Tool for Immunotherapy Side Effects

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My patient is receiving immunotherapy. What is the best tool for assessing side effects?

Anxiety, Depression in Prostate Cancer: Managing Psychosocial Effects in Male Patients

Anxiety, Depression in Prostate Cancer: Managing Psychosocial Effects in Male Patients

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A review of how emotions, social perceptions, and physical effects influence coping skills for men with prostate cancer.

CNS Tumors in Childhood: Predicting Successful Independence in Adult Life

CNS Tumors in Childhood: Predicting Successful Independence in Adult Life

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Researchers at St Jude Children's Research Hospital sought to determine what indicators in survivors of CNS tumors can predict the survivor's ability to live independently as an adult.

Infections in Primary Immune Thrombocytopenia Associated With Low Platelet Count

Infections in Primary Immune Thrombocytopenia Associated With Low Platelet Count

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A retrospective study of platelet- and infection-related data from patients with ITP revealed the influence platelet levels have on infections as well as efficacy of transfusions.

Immune Checkpoint Inhibitors: A Review of Side Effects, Their Causes and Incidence

Immune Checkpoint Inhibitors: A Review of Side Effects, Their Causes and Incidence

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A multicenter research team determined the incidence and type of fatal toxic effects associated with immune checkpoint inhibitors.

Estimating Quality of Life Based on Cumulative Drug Toxicity in Colorectal Cancer

Estimating Quality of Life Based on Cumulative Drug Toxicity in Colorectal Cancer

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Results of a study in which more than 100 patients with metastatic colorectal cancer completed EORTC-QLQ-C30 suggests an association between assessment of cumulative drug toxicities and predictions of quality of life for patients undergoing first-line chemotherapy for the disease.

Pulmonary Toxicity Increased in Pediatric Hodgkin Lymphoma Treated With Brentuximab Vedotin

Pulmonary Toxicity Increased in Pediatric Hodgkin Lymphoma Treated With Brentuximab Vedotin

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A retrospective study evaluated the efficacy vs pulmonary toxicity of brentuximab vedotin for relapsed or refractory Hodgkin lymphoma in pediatric patients.

Late Lower Cranial Neuropathy Worsens Symptom Burden in Oropharyngeal Cancer Survivors

Late Lower Cranial Neuropathy Worsens Symptom Burden in Oropharyngeal Cancer Survivors

Researchers conducted a cross-sectional study to determine the incidence and effect of late lower cranial neuropathies on survivors of oropharyngeal cancers.

SD-101 May Enhance the Effectiveness of Immunotherapy in Melanoma

SD-101 May Enhance the Effectiveness of Immunotherapy in Melanoma

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In this phase 1b study, researchers evaluated the efficacy of immunotherapy with pembrolizumab to treat advanced melanoma.

Pre-HSCT Conditioning May Improve Physical Functioning in Hematologic Cancers

Pre-HSCT Conditioning May Improve Physical Functioning in Hematologic Cancers

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In this retrospective study, researchers assessed the outcomes of 88 patients with hematologic disease who underwent HSCT.

Nonmyeloablative/Reduced-Intensity Conditioning May Reduce Mucositis in HCT

Nonmyeloablative/Reduced-Intensity Conditioning May Reduce Mucositis in HCT

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Researchers sought to determine if NMA or reduced-intensity conditioning with busulfan improved severity/duration of oral mucositis compared with myeloablative conditioning in patients with hematologic cancer undergoing HCT.

FDA, EU Approvals Sought for Split Dose Regimen of Daratumumab for Multiple Myeloma

FDA, EU Approvals Sought for Split Dose Regimen of Daratumumab for Multiple Myeloma

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The manufacturer of daratumumab, a CD38-directed antibody for the treatment of multiple myeloma, has submitted a sBLA and a type II variation to the US FDA and European Medicines Agency, respectively, for approval of a split dosing regimen.

8 Hours of Bedrest May Be Ideal After Intrathecal Chemotherapy in Hematologic Cancers

8 Hours of Bedrest May Be Ideal After Intrathecal Chemotherapy in Hematologic Cancers

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In an open-label study, researchers sought to determine the optimal amount of bed rest after intrathecal chemotherapy for patients with hematologic cancers.

Assessing Direct Costs of Treatment-Related Adverse Events in Advanced Melanoma

Assessing Direct Costs of Treatment-Related Adverse Events in Advanced Melanoma

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In a systematic review, researchers explored the financial burden of treating grade 3 to 4 adverse events associated with melanoma and its treatment.

Healthcare Use, Economic Burden Greater With Cancer-Related Opioid-Induced Constipation

Healthcare Use, Economic Burden Greater With Cancer-Related Opioid-Induced Constipation

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Use of opioids to manage cancer-related pain may have adverse effects of its own that can have a significant impact on healthcare use among patients with cancer.

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