Adverse Effects

Survey Demonstrates Relationship Between Symptom Burden, Medical Disability Leave Among Myeloproliferative Neoplasms

Survey Demonstrates Relationship Between Symptom Burden, Medical Disability Leave Among Myeloproliferative Neoplasms

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A survey-based study investigated the relationship between symptom burden and incidence of medical disability leave among patients with MPNs.

Sequential Immunotherapy, Targeted Therapy Linked to Cutaneous Adverse Events in Advanced Melanoma

Sequential Immunotherapy, Targeted Therapy Linked to Cutaneous Adverse Events in Advanced Melanoma

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Results of a retrospective chart review of patients with BRAF-mutant metastatic melanoma receiving sequential treatment with immunotherapy and targeted therapy or vice versa are presented.

Toxicity From All-Grade Adverse Events in Prostate Cancer Better Reflects QoL

Toxicity From All-Grade Adverse Events in Prostate Cancer Better Reflects QoL

Patient-reported toxicity scores more associated with quality-of-life outcomes than clinician-reported scores, according to study data.

USPSTF Recommends Risk-Reducing Medications for Breast Cancer

USPSTF Recommends Risk-Reducing Medications for Breast Cancer

The USPSTF recommends that clinicians offer to prescribe risk-reducing medications for women who are at increased risk for breast cancer, with some exceptions.

Oncologist Interpretations of CIPN Symptoms Show Disconnect With Patient Reports

Oncologist Interpretations of CIPN Symptoms Show Disconnect With Patient Reports

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Study sought to determine the degree of accuracy between patients' reports and clinicians' interpretation of CIPN symptoms.

Phenotypes Affecting Pain, Opioid Use After Cancer-Related Breast Surgery

Phenotypes Affecting Pain, Opioid Use After Cancer-Related Breast Surgery

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Women undergoing cancer-related breast surgery who display high temporal summation of pain and negative affect before surgery were found to be more likely to experience significant postsurgical pain and continued opioid use.

Early Post-RP Complications Directly Related to Age

Early Post-RP Complications Directly Related to Age

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The risk of virtually all early postoperative complications increases with increasing patient age at radical prostatectomy for localized prostate cancer.

Malignant Pleural Effusion Interventions: What Matters Most to the Patient?

Malignant Pleural Effusion Interventions: What Matters Most to the Patient?

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Patients with malignant pleural effusion may care more about relieving symptoms such as dyspnea as opposed to achieving pleurodesis.

Gastrointestinal Perforation Complicates Management of Mantle Cell Lymphoma

Gastrointestinal Perforation Complicates Management of Mantle Cell Lymphoma

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A patient case illustrates the need for high suspicion of GI perforation and patient education on symptoms of potential adverse effects in certain patients with gastrointestinal lymphoma.

Risk of Therapy-Related MDS, AML Increased by Use of Leukemogenic Chemotherapy Agents

Risk of Therapy-Related MDS, AML Increased by Use of Leukemogenic Chemotherapy Agents

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Researchers sought to determine the association between chemotherapy, particularly platinum-based agents, and increased risk of tMDS/AML.

All-Grade AE Profiles Better Measure of Quality of Life in Metastatic Castration-Naïve Prostate Cancer

All-Grade AE Profiles Better Measure of Quality of Life in Metastatic Castration-Naïve Prostate Cancer

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A study evaluating patient vs clinician reports of adverse events reveals which measures provide a more accurate perspective on patient quality of life.

Fertility Preservation Comes to the Forefront of Radiation Therapy

Fertility Preservation Comes to the Forefront of Radiation Therapy

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Younger age at diagnosis and delayed childbearing are reprioritizing fertility-preserving treatment options.

HNC Survivors Continue to Experience Chronic Systemic Symptoms at 1 Year or More Posttreatment

HNC Survivors Continue to Experience Chronic Systemic Symptoms at 1 Year or More Posttreatment

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Researchers assessed self-reports of chronic systemic symptoms experienced by head and neck cancer survivors at least 1 year posttreatment.

Study Determines Preferred Attributes of PI Combination Therapies for R/R Multiple Myeloma

Study Determines Preferred Attributes of PI Combination Therapies for R/R Multiple Myeloma

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In this study, researchers sought to determine the preferred treatment attributes of patients with RRMM, and which they are willing to let go in trade-offs.

CIPN in Breast Cancer: Do Subjective and Objective Measures Correlate?

CIPN in Breast Cancer: Do Subjective and Objective Measures Correlate?

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Researchers sought to determine how subjective measures of CIPN correlated with objective measures of CIPN.

Patients, Physicians Do Not Recognize Fatigue the Same

Patients, Physicians Do Not Recognize Fatigue the Same

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A worldwide survey reveals that despite similar perceptions on symptom burden of ITP, patients and physicians do not agree on the effect of fatigue on quality of life.

ADT May Up Risk for Heart Failure in Prostate Cancer Patients

ADT May Up Risk for Heart Failure in Prostate Cancer Patients

Heart failure risk was found to be higher for androgen deprivation therapy users in a propensity score-matched analysis.

Lung Cancer-Specific Distress Screening Tool Not Needed But Has Potential Benefit

Lung Cancer-Specific Distress Screening Tool Not Needed But Has Potential Benefit

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Using focus groups, researchers evaluated patient-reported psychosocial consequences of lung cancer to determine if a lung cancer-specific distress screening instrument would benefit these patients.

Report From Childhood Cancer Survivor Study Identifies Long-Term Risks for VTE

Report From Childhood Cancer Survivor Study Identifies Long-Term Risks for VTE

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Assessment of long-term risks for VTE based on data from almost 30,000 childhood cancer survivors and siblings, with approximately 21 years of follow-up.

Hodgkin Lymphoma Survivorship Marked by Periods of Actionable Distress

Hodgkin Lymphoma Survivorship Marked by Periods of Actionable Distress

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A retrospective evaluation of patients treated at a tertiary cancer center demonstrated that patients with Hodgkin lymphoma experienced periods of actionable distress in survivorship, despite a low overall distress burden.

Commission Seeks Standardized Adverse Event Assessments in Hematologic Malignancies

Commission Seeks Standardized Adverse Event Assessments in Hematologic Malignancies

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A snapshot of an international Commission's report on the issues inherent with adverse event reports of hematologic malingnancies in clinical trials.

ASCO, SITC Release Recommendations for Clinical Trial Reporting of Immunotherapy Adverse Events

ASCO, SITC Release Recommendations for Clinical Trial Reporting of Immunotherapy Adverse Events

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As immunotherapies gain a stronger foothold as a treatment option for cancer, ASCO and SITC convened a panel to develop recommendations to ensure consistent and efficient clinical trial reporting in immuno-oncology.

Predictive Role of Skin Rash in Advanced Pancreatic Cancer Patients Treated With Gemcitabine Plus Erlotinib: A Systematic Review and Meta-analysis

Predictive Role of Skin Rash in Advanced Pancreatic Cancer Patients Treated With Gemcitabine Plus Erlotinib: A Systematic Review and Meta-analysis

[OncoTargets and Therapy] In this systematic review and meta-analysis, researchers sought to determine the predictive value of skin rash in patients with advanced pancreatic cancer treated with gemcitabine plus erlotinib.

Chemotherapy Side Effects in Women vs Men: Broader Range, More Severe

Chemotherapy Side Effects in Women vs Men: Broader Range, More Severe

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An analysis of pooled data from 4 randomized controlled clinical trials revealed that male and female patients experience different chemotherapy side effects and at different severities, according to a poster presented at ESMO 2018 Congress.

Strength and Hope for Women in the Mist of Cancer

Strength and Hope for Women in the Mist of Cancer

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A review of the most feared effects of breast cancer treatment and resources to recommend to patients coping with these effects.

Prospective Study Measures Cognitive, Treatment Effects in Older Breast Cancer Survivors

Prospective Study Measures Cognitive, Treatment Effects in Older Breast Cancer Survivors

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Thinking and Living With Cancer (TLC) sought to determine the effects of breast cancer treatment and age on cognitive function in older breast cancer survivors over time.

Immune Checkpoint Inhibitor Therapy May Affect Thyroid Function

Immune Checkpoint Inhibitor Therapy May Affect Thyroid Function

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A review of medical records revealed that thyroid function may be affected by immune checkpoint inhibitor therapy, and these patients should undergo thyroid function tests, especially during the first 8 weeks of therapy.

Hypofractionated Radiotherapy After Conservative Surgery May Increase Low-intermediate Grade Late Fibrosis in Breast Cancer Patients

Hypofractionated Radiotherapy After Conservative Surgery May Increase Low-intermediate Grade Late Fibrosis in Breast Cancer Patients

[Breast Cancer: Targets and Therapy] Researchers sought to determine the incidence of subcutaneous side effects in patients with early-stage breast cancer treated with AHF-RT vs standard fractionated RT after breast conserving surgery.

Self-Care Toolkits Ease Negative PostSurgery Experiences for Patients With Breast Cancer

Self-Care Toolkits Ease Negative PostSurgery Experiences for Patients With Breast Cancer

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Self-care toolkits were found to reduce pain and other negative postsurgical experiences for women undergoing surgical procedures for breast cancer.

Assessment Tool for Immunotherapy Side Effects

Assessment Tool for Immunotherapy Side Effects

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My patient is receiving immunotherapy. What is the best tool for assessing side effects?

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