Adverse Effects

Self-Care Toolkits Ease Negative PostSurgery Experiences for Patients With Breast Cancer

Self-Care Toolkits Ease Negative PostSurgery Experiences for Patients With Breast Cancer

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Self-care toolkits were found to reduce pain and other negative postsurgical experiences for women undergoing surgical procedures for breast cancer.

Assessment Tool for Immunotherapy Side Effects

Assessment Tool for Immunotherapy Side Effects

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My patient is receiving immunotherapy. What is the best tool for assessing side effects?

Anxiety, Depression in Prostate Cancer: Managing Psychosocial Effects in Male Patients

Anxiety, Depression in Prostate Cancer: Managing Psychosocial Effects in Male Patients

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A review of how emotions, social perceptions, and physical effects influence coping skills for men with prostate cancer.

CNS Tumors in Childhood: Predicting Successful Independence in Adult Life

CNS Tumors in Childhood: Predicting Successful Independence in Adult Life

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Researchers at St Jude Children's Research Hospital sought to determine what indicators in survivors of CNS tumors can predict the survivor's ability to live independently as an adult.

Infections in Primary Immune Thrombocytopenia Associated With Low Platelet Count

Infections in Primary Immune Thrombocytopenia Associated With Low Platelet Count

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A retrospective study of platelet- and infection-related data from patients with ITP revealed the influence platelet levels have on infections as well as efficacy of transfusions.

Estimating Quality of Life Based on Cumulative Drug Toxicity in Colorectal Cancer

Estimating Quality of Life Based on Cumulative Drug Toxicity in Colorectal Cancer

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Results of a study in which more than 100 patients with metastatic colorectal cancer completed EORTC-QLQ-C30 suggests an association between assessment of cumulative drug toxicities and predictions of quality of life for patients undergoing first-line chemotherapy for the disease.

Late Lower Cranial Neuropathy Worsens Symptom Burden in Oropharyngeal Cancer Survivors

Late Lower Cranial Neuropathy Worsens Symptom Burden in Oropharyngeal Cancer Survivors

Researchers conducted a cross-sectional study to determine the incidence and effect of late lower cranial neuropathies on survivors of oropharyngeal cancers.

SD-101 May Enhance the Effectiveness of Immunotherapy in Melanoma

SD-101 May Enhance the Effectiveness of Immunotherapy in Melanoma

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In this phase 1b study, researchers evaluated the efficacy of immunotherapy with pembrolizumab to treat advanced melanoma.

Nonmyeloablative/Reduced-Intensity Conditioning May Reduce Mucositis in HCT

Nonmyeloablative/Reduced-Intensity Conditioning May Reduce Mucositis in HCT

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Researchers sought to determine if NMA or reduced-intensity conditioning with busulfan improved severity/duration of oral mucositis compared with myeloablative conditioning in patients with hematologic cancer undergoing HCT.

FDA, EU Approvals Sought for Split Dose Regimen of Daratumumab for Multiple Myeloma

FDA, EU Approvals Sought for Split Dose Regimen of Daratumumab for Multiple Myeloma

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The manufacturer of daratumumab, a CD38-directed antibody for the treatment of multiple myeloma, has submitted a sBLA and a type II variation to the US FDA and European Medicines Agency, respectively, for approval of a split dosing regimen.

8 Hours of Bedrest May Be Ideal After Intrathecal Chemotherapy in Hematologic Cancers

8 Hours of Bedrest May Be Ideal After Intrathecal Chemotherapy in Hematologic Cancers

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In an open-label study, researchers sought to determine the optimal amount of bed rest after intrathecal chemotherapy for patients with hematologic cancers.

Assessing Direct Costs of Treatment-Related Adverse Events in Advanced Melanoma

Assessing Direct Costs of Treatment-Related Adverse Events in Advanced Melanoma

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In a systematic review, researchers explored the financial burden of treating grade 3 to 4 adverse events associated with melanoma and its treatment.

Healthcare Use, Economic Burden Greater With Cancer-Related Opioid-Induced Constipation

Healthcare Use, Economic Burden Greater With Cancer-Related Opioid-Induced Constipation

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Use of opioids to manage cancer-related pain may have adverse effects of its own that can have a significant impact on healthcare use among patients with cancer.

Carfilzomib Benefits May Outweigh Cardiovascular Risk in Multiple Myeloma

Carfilzomib Benefits May Outweigh Cardiovascular Risk in Multiple Myeloma

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In an analysis of 11 studies, researchers investigated whether the benefits of carfilzomib for multiple myeloma outweigh the cardiovascular risks. However, the researchers recommend careful monitoring and management of blood pressure and volume status as good clinical practice, regardless.

Genetic Link Between Depression and Breast Cancer Remains Unclear

Genetic Link Between Depression and Breast Cancer Remains Unclear

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In this study, researchers sought to determine if a genetic predisposition to depression exists in some patients with breast cancer and how to identify it.

Chinese Traditional Medicine Showed Effectiveness on Pain, Quality of Life in Advanced Cancer

Chinese Traditional Medicine Showed Effectiveness on Pain, Quality of Life in Advanced Cancer

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In a randomized study, researchers sought to determine the effect of IV injections of coix seed oil, a Chinese CAM, on pain and quality of life measures for patients with advanced cancer.

Handgrip Force May Provide Objective Evaluation of Cancer-Related Fatigue

Handgrip Force May Provide Objective Evaluation of Cancer-Related Fatigue

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Researchers sought to determine if handgrip force could provide objective measures of CRF in patients with cancer.

CALM: A Depression Intervention for Cancer Patients at the End of Life

CALM: A Depression Intervention for Cancer Patients at the End of Life

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The effectiveness of a novel intervention intended to reduce and/or prevent depression in patients with advanced cancer at the end of life was investigated in a randomized study with more than 300 patients.

Live or Online Mindfulness-Based Cognitive Therapy Reduced Cancer-Related Psychological Distress

Live or Online Mindfulness-Based Cognitive Therapy Reduced Cancer-Related Psychological Distress

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Mindfulness-based interventions are proven effective in helping patients with cancer manage distress and other psychological symptoms. In this study, researchers sought to determine if Internet-based MBCT can be as effective as face-to-face interventions.

PTSD May Increase Symptom Burden in Patients With Cancer

PTSD May Increase Symptom Burden in Patients With Cancer

Post-traumatic stress symptoms are linked to a greater symptom burden in hospitalized cancer patients.

Managing Dyspnea With Fentanyl in Patients With Cancer at End of Life

Managing Dyspnea With Fentanyl in Patients With Cancer at End of Life

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In this retrospective study, researchers sought to determine the effectiveness of fentanyl for dyspnea in dying patients with advanced cancer.

Malnutrition, Decreased QOL Possible After Radiation Therapy for Head and Neck Cancer

Malnutrition, Decreased QOL Possible After Radiation Therapy for Head and Neck Cancer

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In a retrospective study, researchers used established tools to measure the nutritional status of patients with head and neck cancer before, immediately after, and at 2 follow-up points after radiotherapy.

Ixazomib, Lenalidomide, Dexamethasone Effective But Increases Toxicity in Multiple Myeloma

Ixazomib, Lenalidomide, Dexamethasone Effective But Increases Toxicity in Multiple Myeloma

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Three-drug regimen twice a week achieved good response and long-term outcomes in patients with newly diagnosed multiple myeloma; however, regimen has higher toxicity than once weekly dose.

Low-Dose Dasatinib for Chronic-Phase CML Safe, Effective With Fewer Adverse Events

Low-Dose Dasatinib for Chronic-Phase CML Safe, Effective With Fewer Adverse Events

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In this study, researchers assigned 75 patients with newly diagnosed Philadelphia chromosome (Ph)-positive CML-CP to receive dasatinib 50 mg once daily.

Childhood Neuroblastoma Survivors at Risk for Psych Impairment

Childhood Neuroblastoma Survivors at Risk for Psych Impairment

Psychological impairment seen particularly in survivors with chronic health conditions.

Navigating the Benefits and Challenges of Immunotherapy

Navigating the Benefits and Challenges of Immunotherapy

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A review of immunotherapy — what they are, how they work, and what to watch for — was presented at the 2018 ONA Navigation Summit.

Muscle Loss Not Always Correlated With Loss of Function, Strength in Cancer Cachexia

Muscle Loss Not Always Correlated With Loss of Function, Strength in Cancer Cachexia

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Interventions specifically designed to target cachexia in patients with thoracic or gastrointestinal cancer and established cachexia were effective in helping patients preserve functional stability and rehabilitation potential.

Association Between Multiple Myeloma With VTE and Increased Mortality at 2, 5 Years

Association Between Multiple Myeloma With VTE and Increased Mortality at 2, 5 Years

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A study presented at the 2018 ASCO Annual Meeting investigated the mortality risk for patients with multiple myeloma who develop VTE.

Primary Prophylaxis Key in Reducing Febrile Neutropenia in Early Breast Cancer

Primary Prophylaxis Key in Reducing Febrile Neutropenia in Early Breast Cancer

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In a retrospective study, researchers investigated the effect of primary prophylaxis on incidence of febrile neutropenia in patients with early stage breast cancer.

Head and Neck Cancer Survival Improved When irAEs Occur During Anti-PD-1 Therapy

Head and Neck Cancer Survival Improved When irAEs Occur During Anti-PD-1 Therapy

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Researchers evaluated whether the development of irAEsc among patients with metastatic head and neck cancer who have failed platinum-based chemotherapy could improve patient outcomes.

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