Adverse Effects

Cisplatin-Induced Adverse Events in Osteosarcoma Not Improved With Pantoprazole

Cisplatin-Induced Adverse Events in Osteosarcoma Not Improved With Pantoprazole

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This phase 2 study sought to determine whether concurrent pantoprazole would improve cisplatin-induced ototoxicity and nephrotoxicity in younger patients with osteosarcoma.

Cardiotoxicity Risk Greater in Blacks With Breast Cancer Receiving HER2 Therapies

Cardiotoxicity Risk Greater in Blacks With Breast Cancer Receiving HER2 Therapies

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Retrospective study examines the association between risk of cardiotoxicity and race in women with breast cancer receiving chemotherapy and at least 1 year of HER2-targeted therapy.

Chemotherapy Toxicity Risk Score Use Improved Treatment Choice for Elderly

Chemotherapy Toxicity Risk Score Use Improved Treatment Choice for Elderly

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This observational study demonstrates the significance of using the chemotherapy toxicity risk score (CTRS) to determine if an elderly patient can safely tolerate standard-dose combination chemotherapy, or would fare better with a reduced-dose regimen.

FDA Issues Warning for Rolapitant Injectable Emulsion in the Treatment of CINV

FDA Issues Warning for Rolapitant Injectable Emulsion in the Treatment of CINV

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FDA issues black box warning for rolapitant regarding the potential for anaphylaxis, anaphylactic shock, and other hypersensitivity reactions in patients receiving the injectable emulsion for CINV prophylaxis.

Nursing and Patient Education on Immunotherapy-related Adverse Events

Nursing and Patient Education on Immunotherapy-related Adverse Events

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The unique adverse events related to treatment with immunotherapy require a proactive approach in the assessment of side effects and patient education.

Short-Term Fasting Alleviates Toxic Effects, High Glucose Levels Associated With Chemotherapy

Short-Term Fasting Alleviates Toxic Effects, High Glucose Levels Associated With Chemotherapy

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Short-term fasting may alleviate toxic effects caused by high blood glucose levels associated with common cancer drugs.

Improving Tools for Managing Pain and Monitoring Sedation Among Patients With Cancer

Improving Tools for Managing Pain and Monitoring Sedation Among Patients With Cancer

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Managing pain with opioids and keeping a close eye on adverse effects is an important part of cancer care. But there is room for improvement in pain management tools, and nurses play a key role in their evolution.

Genetic Biomarker Predictive of Peripheral Neuropathy in Patients Receiving Docetaxel for Prostate Cancer

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Docetaxel-induced neuropathy may be predicted by single nucleotide polymorphisms in VAC14.

Chemo-related Bloodstream Infection Predicted by Gut Microbes Before Treatment

Chemo-related Bloodstream Infection Predicted by Gut Microbes Before Treatment

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Bacteria present in the gut may predict a patient's risk for life-threatening blood infections after high-dose chemotherapy.

Standards Established for Psychosocial Care of Children With Cancer and Their Families

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A group of pediatric oncology psychosocial experts developed evidence-based standards for the care of children with cancer and their families.

Loss of Muscle Mass Impacts Outcomes for Patients With mCRC Receiving Chemotherapy

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A significant decrease in muscle area was seen in patients with metastatic colorectal cancer (mCRC) receiving chemotherapy, which was independently associated with survival in these patients.

Bone Pain Due to White Blood Cell Growth Factors

Bone Pain Due to White Blood Cell Growth Factors

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How is loratadine used to treat bone pain in patients receiving white blood cell growth factors?

Delirium is Common in Older Patients Undergoing GI Surgery

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Older patients undergoing gastrointestinal surgery often experience postoperative delirium. In an analysis of 11 studies, incidence of postoperative delirium ranged from 8.2% to 54.4%.

Novel Paste Prevents Adverse Skin Effects from Radiotherapy for Cancer

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An antiscarring paste halted the fibrosis caused by the radiation used in cancer therapy when applied to the skin of mice, according to early findings of a recent study.

New Studies Reveal Long-Term Vision-related Health Concerns of Survivors of Childhood Retinoblastoma and Brain Cancer

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Two new studies investigate the impact of retinoblastoma on long-term health of survivors and the long-term psychological and socio-economic effects of blindness in survivors of brain tumors.

Risks of Adverse Effects Lower With Surgical Castration Vs. Chemical Castration for Metastatic Prostate Cancer

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Surgical castration via orchiectomy for metastatic prostate cancer is associated with lower risks for adverse effects compared with medical castration via GnRHa therapy.

Symptom Count Shows Potential as Diagnostic Tool for Lymphedema in Breast Cancer Survivors

Symptom Count Shows Potential as Diagnostic Tool for Lymphedema in Breast Cancer Survivors

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Nurse researchers examined the validity, sensitivity, and specificity of various symptoms indicative of breast cancer-related lymphedema. They also determined the best cutoff points for diagnosing lymphedema and risk of lymphedema in breast cancer survivors.

Discrepancies Exist Between Patient and Clinician Reports of Adjuvant Chemotherapy-related Adverse Effects

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Patient self-reports of adjuvant chemotherapy-related adverse effects are consistently higher in frequency and greater in severity than physician reports, according to a recent study.

HNG Protects the Immune System and Preserves Fertility in Patients Receiving Chemotherapy

HNG Protects the Immune System and Preserves Fertility in Patients Receiving Chemotherapy

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Humanin analogue protects both male germ cells, essential to fertility, and white blood cells, the soldiers in the body's defense system, during chemotherapy.

Depressed Head and Neck Cancer Patients Have Lower Survival and Higher Recurrence Risk

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Depression is a significant predictor of 5-year survival and recurrence in patients with head and neck cancer. These findings represent one of the largest studies to report on the impact of depression on cancer survival.

Mindfulness-based Stress Reduction Reduces Cognitive Deficits in Survivors of Breast and Colorectal Cancers

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Participation in an MBSR program yields robust and sustained improvement in cancer-related cognitive impairment.

Medical Records Reveal Alzheimer Diagnoses Higher Among Patients Receiving ADT for Prostate Cancer

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In a study that demonstrates the emerging technique of extracting biomedical data from ordinary patient medical records, a nearly 2-fold increase was seen in the rate of Alzheimer disease diagnoses among men with prostate cancer who received ADT.

Association Is Found Between Bone Complications in Young Pediatric Patients With Leukemia and Gene Variations

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Variations in genes involved in normal bone development are associated with an 8- to 15-fold increased risk for osteonecrosis in young patients with acute lymphoblastic leukemia (ALL).

Lower Survival Rates in Women With Breast Cancer Diagnosed With Depression

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Risk of death from all causes is 45% higher in women with breast cancer and a subsequent diagnosis of depression, according to a recent study. This finding could help identify those women most at risk for depression and in need of support.

Cognitive-behavioral Stress Management Improves Treatment and Survival in Women With Breast Cancer

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Women who were taught how to manage stress early in their breast cancer treatment showed greater length of survival and longer time until disease recurrence over 8 to 15 years after their original diagnosis.

Using genomic correlates of radiotoxicity to predict patient outcomes

Using genomic correlates of radiotoxicity to predict patient outcomes

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Radiogenomics is maturing into a predictor of patients' likelihood of experiencing radiotoxicities and late radiation effects.

Managing adverse effects of NSCLC treatment

Managing adverse effects of NSCLC treatment

EGFR inhibitors are widely used to treat metastatic NSCLC; however, they can cause various adverse effects that differ from those caused by traditional intravenous chemotherapy.

Smoking and smoke exposure increase adverse pregnancy outcomes

Smoking and smoke exposure increase adverse pregnancy outcomes

Increased odds for spontaneous abortions, stillbirths, and ectopic pregnancies were seen for smokers, compared to never-smoking women.

Existing treatment may stop tamoxifen-induced fog

Existing treatment may stop tamoxifen-induced fog

Researchers have not only confirmed that tamoxifen induces cognitive dysfunction in users, they have also found an existing treatment that can prevent this adverse effect.

Hodgkin treatment raises risk for stomach cancer

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Survivors of Hodgkin lymphoma who received subdiaphragmatic radiotherapy had dose-dependent increased risk for stomach cancer, researchers discovered.

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