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ZYVOX I.V. INJECTION
Bacterial infections
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Drug Name:

ZYVOX I.V. INJECTION Rx

Generic Name and Formulations:
Linezolid 2mg/mL; soln for IV infusion; sodium content 0.38mg/mL.

Company:
Pfizer Inc.

Therapeutic Use:

Indications for ZYVOX I.V. INJECTION:

Susceptible vancomycin-resistant E. faecium (VREF) infections, nosocomial and community-acquired pneumonia, complicated skin and skin structure infections (including diabetic foot infections) without osteomyelitis, uncomplicated skin and skin structure infections.

Adult:

Infuse inj over 30–120 mins; switch to oral form when appropriate. VREF: 600mg every 12hrs for 14–28 days. Pneumonia, complicated skin and skin structure: 600mg every 12hrs for 10–14 days. Uncomplicated skin and skin structure (oral forms only): 12–17yrs: 600mg every 12hrs; >17yrs: 400mg every 12hrs; both for 10–14 days. MRSA: 600mg every 12hrs.

Children:

Infuse inj over 30–120 mins; switch to oral form when appropriate. Neonates <7 days: see full labeling. 0–11yrs: VREF: 10mg/kg every 8hrs for 14–28 days; pneumonia, complicated skin and skin structure: 10mg/kg every 8hrs for 10–14 days. Uncomplicated skin and skin structure (oral forms only): <5yrs: 10mg/kg every 8hrs; 5–11yrs: 10mg/kg every 12hrs; both for 10–14 days.

Contraindications:

During or within 2 weeks of MAOIs (eg, phenelzine, isocarboxazid).

Warnings/Precautions:

Not for treating catheter-related bloodstream infections or catheter-site infections. Uncontrolled hypertension, pheochromocytoma, thyrotoxicosis, carcinoid syndrome: not recommended. History of seizures. Monitor CBC's weekly (esp. if otherwise at risk). Consider discontinuing if myelosuppression occurs or worsens. Therapy >28 days. Peripheral and optic neuropathy. Monitor visual function if treatment ≥3 months and if new visual symptoms occur. Diabetes; monitor for hypoglycemia, if occurs, reduce dose or discontinue. Pregnancy (Cat.C). Nursing mothers.

Interactions:

See Contraindications. Concomitant sympathomimetics (eg, pseudoephedrine), vasopressive agents (eg, epinephrine, norepinephrine), dopaminergics (eg, dopamine, dobutamine): not recommended. Risk of serotonin syndrome with concomitant SSRIs, trycyclic antidepressants, triptans, meperidine, bupropion, or buspirone. Avoid large amounts of dietary tyramine (keep <100mg/meal). May be antagonized by carbamazepine, phenytoin, phenobarbital. Caution with myelosuppressants.

See Also:

ZYVOX

ZYVOX for ORAL SUSP

Pharmacological Class:

Oxazolidinone.

Adverse Reactions:

Diarrhea, vomiting, nausea, anemia, headache, rash, dizziness, pruritus, tongue discoloration, taste alteration; myelosuppression (eg, anemia, thrombocytopenia), lactic acidosis, C.difficile-associated diarrhea, hypoglycemia, blurred vision, convulsion.

Generic Availability:

Tabs, Inj (YES); susp (NO)

How Supplied:

Tabs—20, 100; Susp—150mL; Inj (100mL, 200mL, 300mL)—1

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