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ZYLET
Ocular allergy/inflammation
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Drug Name:

ZYLET Rx

Generic Name and Formulations:
Loteprednol etabonate 0.5% + tobramycin 0.3%, oph susp; contains benzalkonium chloride.

Company:
Bausch & Lomb Inc.

Therapeutic Use:

Indications for ZYLET:

Ocular inflammation associated with infection or risk thereof.

Adult:

Instill 1–2 drops into the conjunctival sac of affected eye(s) every 4–6 hours; may increase to every 1–2 hours in first 24–48 hours; reduce dose as symptoms improve; max 20mL for first ℞. Reevaluate if no improvement after 2 days.

Children:

Not recommended.

Contraindications:

Ocular fungal, viral, or mycobacterial infections.

Warnings/Precautions:

Corneal or scleral thinning. Glaucoma. Monitor IOP and for secondary infections and for cataracts in prolonged use (>10 days). Monitor blood levels in combined aminoglycoside therapy. Avoid abrupt cessation. Soft contact lenses (remove during therapy). Pregnancy (Cat.C). Nursing mothers.

Pharmacological Class:

Steroid + aminoglycoside.

Adverse Reactions:

Secondary ocular infections, injection, superficial punctate keratitis, increased IOP, ocular discomfort (eg, burning, stinging, itching, discharge) visual/lacrimation/eyelid disorder, photophobia, corneal deposits, headache. May mask or exacerbate ocular infections. May delay wound healing and increase bleb formation after cataract surgery. In prolonged use: increased IOP, optic nerve damage, cataract formation, corneal perforation.

How Supplied:

Susp—2.5mL, 5mL, 10mL

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