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ZORPRIN
Arthritis/rheumatic disorders
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Drug Name:

ZORPRIN Rx

Generic Name and Formulations:
Aspirin 800mg; pH-dependent release tabs.

Company:
Par Pharmaceutical, Inc.

Therapeutic Use:

Indications for ZORPRIN:

Rheumatoid arthritis (RA). Juvenile rheumatoid arthritis (JRA). Spondyloarthropathies. Osteoarthritis (OA). Arthritis and pleurisy of systemic lupus erythematosus (SLE).

Adult:

Swallow whole with ≥8oz of fluids. RA, SLE: initially 3g daily in divided doses; target plasma salicylate level 150–300micrograms/mL. OA: up to 3g/day in divided doses. Spondyloarthropathies: up to 4g/day in divided doses.

Children:

<25kg: not recommended. ≥25kg: JRA: initially 90–130mg/kg per day in divided doses; target plasma salicylate level 150–300micrograms/mL.

Contraindications:

NSAID allergy. Asthma, rhinitis or nasal polyps. Viral infection in children and teenagers. Children with fever or weigh <25 kg.

Warnings/Precautions:

Not for antipyresis or short-term analgesia. Severe hepatic or renal dysfunction; avoid. Bleeding disorders. History of GI bleed/peptic ulcer. Diabetes. Gout. Labor and delivery; avoid 1 week before and during. Pregnancy (avoid in 3rd trimester), nursing mothers: not recommended.

Interactions:

Potentiates anticoagulants, oral hypoglycemics, methotrexate, acetazolamide, valproic acid or highly protein-bound drugs. Urinary alkalinizers, antacids, corticosteroids, gastric acid secretion inhibitors may increase excretion. May antagonize ACE inhibitors, β-blockers, diuretics or uricosurics. Increased bleeding risk with anticoagulants, NSAIDs or chronic, heavy alcohol use. NSAIDs increase risk of renal dysfunction.

Pharmacological Class:

Salicylate.

Adverse Reactions:

GI upset/bleed, prolonged bleeding time, anaphylaxis, salicylism (eg, tinnitus), dysrhythmias, agitation, cerebral or pulmonary edema, dehydration, hyperkalemia, elevated hepatic enzymes, angioedema, hyperpnea, Reye's syndrome, coagulopathy, others.

How Supplied:

Tabs—100

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