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ZORBTIVE
Colorectal disorders
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Drug Name:

ZORBTIVE Rx

Generic Name and Formulations:
Somatropin (rDNA origin) 8.8mg; per vial; lyophilized pwd for SC inj after reconstitution; diluent contains benzyl alcohol.

Company:
EMD Serono, Inc.

Therapeutic Use:

Indications for ZORBTIVE:

Short bowel syndrome in conjunction with nutritional support (see full labeling).

Adult:

Rotate inj site. Initially 0.1mg/kg SC inj once daily; max 8mg/day. Treat for 4 weeks. If fluid retention or arthralgia occurs; reduce dose by 50%. Discontinue therapy for up to 5 days if severe toxicities occur; if resolved, resume at 50% of original dose; if unresolved within 5 days or recurs, discontinue permanently.

Children:

Not established.

Contraindications:

Active malignancy. Acute critical illness due to complications following open heart or abdominal surgery, multiple accidental trauma, or acute respiratory failure. Active proliferative or severe non-proliferative diabetic retinopathy.

Warnings/Precautions:

Monitor for potential malignant changes of preexisting nevi. Increased mortality in those with acute critical illness (see Contraindications). Impaired glucose tolerance/diabetes mellitus: monitor blood glucose. Hypoadrenalism: monitor serum cortisol levels. Evaluate thyroid function in those with hypopituitarism before starting and after 4 weeks treatment; correct thyroid function, if needed. Perform funduscopic evaluation for intracranial hypertension at initiation; discontinue if papilledema occurs. Elderly. Pregnancy. Nursing mothers.

Interactions:

May antagonize glucocorticoids. Concomitant antidiabetic treatment may need to be adjusted.

Pharmacological Class:

Growth hormone (GH).

Adverse Reactions:

Edema (eg, facial, peripheral), arthralgia, inj site pain, flatulence, abdominal pain, vomiting, pain, nausea; hypersensitivity reactions, tissue turgor (swelling in hands/feet), musculoskeletal discomfort, carpal tunnel syndrome (reduce dose or discontinue if unresolved), acute pancreatitis.

How Supplied:

Vials—1 (w. diluent)

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