Generic Name and Formulations:
Doxepin HCl 5%; crm.
Indications for ZONALON:
Moderate pruritus associated with atopic dermatitis and lichen simplex chronicus.
Apply thin film to affected area 4 times a day at 3–4 hour intervals for up to 8 days. Do not occlude.
Untreated narrow-angle glaucoma. Urinary retention.
During or within 14 days of MAOIs. Poor metabolizers may have increased effects. For dermatological use only. Avoid eyes. Pregnancy (Cat.B). Nursing mothers: not recommended.
Discontinue MAOIs at least 2 weeks before starting. Alcohol, CNS depressants potentiate sedation. May potentiate drugs metabolized by CYP2D6 (eg, cimetidine, tricyclic antidepressants, SSRIs, phenothiazines, carbamazepine, propafenone, flecainide, encainide, quinidine).
Drowsiness, dry mouth, thirst, headache, fatigue, dizziness, emotional or taste changes, burning/stinging, pruritus or eczema exacerbation, skin dryness or tightening, parethesias, edema.
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